Efficacy and safety of tacrolimus combined with glucocorticoid treatment for IgA nephropathy: a meta-analysis

Zhang, Yong; Luo, Jun; Hu, Bin; Ma, Teng

doi:10.1177/0300060518776566

Cited by 15 publications

(14 citation statements)

References 36 publications

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“…However, TAC was the least effective at preventing the progression of IgAN, leading to more patients suffering from ESRD as well as intolerable side effects. A previous pairwise meta-analysis clearly concluded that TAC was a promising drug for IgAN without an increased risk of side effects, but these results were not exactly the same as ours 36 . That previous study did not take renal outcomes into consideration.…”

Section: Discussioncontrasting

confidence: 77%

The efficacy and safety of immunosuppressive therapies in the treatment of IgA nephropathy: A network meta-analysis

Tan

Dong

et al. 2020

Sci Rep

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The protocol of this systematic review and network meta-analysis was submitted to the PROSPERO register and the registration number is CRD42019122324. The original data are available in the supplementary information. Because no human beings or animals were part of this study, ethics committee approval was not required. Search strategies. Two investigators (TJX and DLQ) independently performed a systematic literature retrieval. Commonly used databases, including Medline, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, and EMBASE, were searched on December 30, 2018, and the last searched date was April 1, 2019. The text-word terms and subject headings we used in this study were "Immunoglobulin A nephropathy", "cyclophosphamide", "azathioprine", "tacrolimus", "mycophenolic acid", "mycophenolate mofetil", "steroids", and "glucocorticoid". The syntax used in each database is shown in Supplementary Table 1 (Table S1). To avoid omitting important articles, we also hand-searched the references of each retrieved study, relevant reviews, editorials and commentary.

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Section: Discussioncontrasting

confidence: 77%

The efficacy and safety of immunosuppressive therapies in the treatment of IgA nephropathy: A network meta-analysis

Tan

Dong

et al. 2020

Sci Rep

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“…If there was no significant heterogeneity, a weighted fixed-effect model was used. Otherwise, a random-effects model was used [21]. Heterogeneity was analysed statistically by the I 2 and Chi 2 statistics.…”

Section: Discussionmentioning

confidence: 99%

Randomized controlled trials for comparison of laparoscopic versus conventional open catheter placement in peritoneal dialysis patients: a meta-analysis

Sun

Zhang²,

Wang

et al. 2020

BMC Nephrol

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Background: The application of laparoscopic catheterization technology in peritoneal dialysis (PD) patients has recently increased. However, the advantages and disadvantages of laparoscopic versus conventional open PD catheter placement are still controversial. The aim of this meta-analysis is to assess the complications of catheterization in PD patients and to provide a reference for choosing a PD-catheter placement technique in the clinic. Methods: We searched numerous databases, including Embase, PubMed, CNKI and the Cochrane Library, for published randomized controlled trials (RCTs). Results: Eight relevant studies (n = 646) were included in the meta-analysis. The pooled results showed a lower incidence of catheter migration (OR: 0.

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“…If there was no significant heterogeneity, a weighted fixed-effect model was used. Otherwise, a random-effects model was used [21] .…”

Section: Discussionmentioning

confidence: 99%

Randomized Controlled Trials for Comparison of Laparoscopic Versus Conventional Open Catheter Placement in Peritoneal Dialysis Patients: A Meta-Analysis

Sun

Zhang

Wang

et al. 2020

Preprint

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Aim: The application of laparoscopic catheterization technology in peritoneal dialysis (PD) patients has recently increased. However, the advantages and disadvantages of laparoscopic versus conventional open PD catheter placement are still controversial. The aim of this meta-analysis is to assess the complications of catheterization in PD patients and to provide a reference for choosing a PD-catheter placement technique in the clinic.Methods: We searched numerous databases, including Embase, PubMed, CNKI and the Cochrane Library, for published randomized controlled trials (RCTs).Results: Eight relevant studies (n=646) were included in the meta-analysis. The pooled results showed a lower incidence of catheter migration (OR: 0.42, 95% CI: 0.19 to 0.90, P: 0.03) and catheter removal (OR: 0.41, 95% CI: 0.21 to 0.79, P: 0.008) but a higher incidence of bleeding (OR: 3.25, 95% CI: 1.18 to 8.97, P: 0.02) with a laparoscopic approach than with a conventional approach. There was no significant difference in the incidence of omentum adhesion (OR: 0.32, 95% CI: 0.05 to 2.10, P: 0.24), hernia (OR: 0.38, 95% CI: 0.09 to 1.68, P: 0.20), leakage (OR: 0.69, 95% CI: 0.38 to 1.26, P: 0.23), intestinal obstruction (OR: 0.96, 95% CI: 0.48 to 1.91, P: 0.90) or perforation (OR: 0.95, 95% CI: 0.06 to 15.42, P: 0.97). The statistical analysis showed no significant difference in early (OR: 0.44, 95% CI: 0.15 to 1.33, P: 0.15) , late (OR: 0.89, 95% CI: 0.41 to 1.90, P: 0.76) or total (OR: 0.68, 95% CI: 0.42 to 1.12, P: 0.13) peritonitis infections between the 2 groups, and there are no no significant difference in early ( OR: 0.39, 95% CI: 0.06 to 2.36, P: 0.30), late ( OR: 1.35, 95% CI: 0.78 to 2.33, P: 0.16) or total ( OR: 1.20, 95% CI: 0.71 to 2.02, P: 0.17) tunnel or exit-site infections between the 2 groups.Conclusion: Laparoscopic catheterization and conventional open catheter placement in PD patients have unique advantages, but laparoscopic PD catheterization may be superior to conventional open catheter placement. However, this conclusion needs to be confirmed with further large-sample-size, multi-centre, high-quality RCTs.

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Efficacy and safety of tacrolimus combined with glucocorticoid treatment for IgA nephropathy: a meta-analysis

Cited by 15 publications

References 36 publications

The efficacy and safety of immunosuppressive therapies in the treatment of IgA nephropathy: A network meta-analysis

The efficacy and safety of immunosuppressive therapies in the treatment of IgA nephropathy: A network meta-analysis

Randomized controlled trials for comparison of laparoscopic versus conventional open catheter placement in peritoneal dialysis patients: a meta-analysis

Randomized Controlled Trials for Comparison of Laparoscopic Versus Conventional Open Catheter Placement in Peritoneal Dialysis Patients: A Meta-Analysis

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