Efficacy and safety of propofol in preventing emergence agitation after sevoflurane anesthesia for children

Abstract

Application of propofol in preventing emergence agitation after sevoflurane anesthesia in children was evaluated. Clinical data of 200 children who received sevoflurane anesthesia in Children's Hospital of Xuzhou Medical University were retrospectively analyzed. Among them, 120 patients who received inhaled sevoflurane for pediatric anesthesia and intravenous infusion of propofol (2 mg/kg) were included in observation group. The remaining 80 cases who were directly anesthetized by sevoflurane alone were the control group. T PAED scores, modified Aldrete scores, extubation time, PACU time and adverse reactions (gastrointestinal tract and respiratory response) were analyzed and compared between the control and observation group. PAED scores, extubation time, PACU time and incidence of adverse reactions were significantly lower in observation than in control group, and the modified Aldrete scores were higher in observation than in control group (P<0.05). Spearman's correlation analysis showed that the PAED scores were negatively correlated with modified Aldrete scores and positively correlated with extubation time. There was positive correlation between the PACU time and incidence of adverse reactions and between the PAED scores and extubation time. There was negative correlation between PACU time and incidence of adverse reactions and between Aldrete scores and extubation time (P<0.05). Therefore, we conclude that propofol can be used to prevent agitation after sevoflurane anesthesia in children.

Postoperative emergence delirium in children: a narrative review of recent publications

“…These findings have been confirmed in a recent study where the infusion of 3 mg/kg propofol over three minutes also was found to reduce ED frequency [24]. Furthermore, a study with an IV propofol administration of 2 mg/kg near the end of sevoflurane anesthesia also reported a significant decrease in the incidence of ED, measured by PAED scale (5.66 ± 1.74 vs 9.87 ± 3.15; P < 0.01) [25]. Fewer adverse events of the gastrointestinal tract and respiratory response (5% vs 13.75%; P = 0.03) were also found.…”

Restoration Algorithm-Based Ultrasound Image in Evaluating the Effect of Dexmedetomidine on Patients with Neurological Disorder Anesthetized by Sevoflurane

“…It is characterized by low aroma irritation, little effect on heart rate and hemodynamics, rapid anesthesia induction, and outstanding sedation and muscle relaxation effects [ 12 , 13 ]. However, it can lead to neurological disorder in the postoperative recovery period, such as vertigo, headache, agitation, nausea and vomiting, and uneven hemodynamic indicators, affecting the physical and mental health of the patient [ 14 , 15 ]. Therefore, it is necessary to use drugs during surgery to prevent adverse reactions caused by sevoflurane anesthesia.…”

The Effect of Dexmedetomidine on Emergence Agitation or Delirium in Children After Anesthesia—A Systematic Review and Meta-Analysis of Clinical Studies

“…In addition, the children undergoing inhalation anesthesia through sevoflurane, isoflurane, or desflurane may suffer from a high incidence of post-anesthesia EA or ED (87,88). Various medications have been used to prevent EA or ED in pediatric patients, like benzodiazepines, opioids, propofol, ketamine, clonidine, dexmedetomidine, and so on (11,(89)(90)(91)(92)(93).…”