Efficacy and safety of premedication with single dose of oral pregabalin in children with dental anxiety: A randomized double-blind placebo-controlled crossover clinical trial

Eskandarian, T; Eftekharıan, Hamıd Reza; Soleymanzade, Rojin

doi:10.4103/1735-3327.170569

Cited by 7 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For minor procedures performed under local anesthesia, Elrashidy et al 38 found that patients scheduled for vitreo-retinal surgery who received preoperative pregabalin demonstrated less anxiety in comparison to placebo. Eskandarian et al 39 premedicated 4-6 years old children scheduled for dental treatment with pregabalin 75 mg and found that it reduced anxiety score significantly. The inconstant findings of the efficacy of pregabalin to reduce preoperative anxiety may be related to confounding factors such as different study population, doses and timing of pregabalin administration, as well as methods and timing of anxiety assessment.…”

Section: Discussionmentioning

confidence: 99%

The anxiolytic effects of preoperative administration of pregabalin in comparison to diazepam and placebo

Nimmaanrat,

Charuenporn,

Jensen

et al. 2023

Sci Rep

View full text Add to dashboard Cite

We aimed to evaluate the potential anxiolytic effects of premedication with pregabalin, compared with diazepam and placebo. We conducted this non-inferiority, double-blind, randomized controlled trial in ASA classification I-II patients aged 18–70 years, scheduled for elective surgery under general anesthesia. They were allocated to receive pregabalin (75 mg the night before surgery and 150 mg 2 h before surgery), diazepam (5 and 10 mg in the same manner) or placebo. Preoperative anxiety was evaluated using verbal numerical rating scale (VNRS) and Amsterdam Preoperative Anxiety and Information Scale (APAIS) before and after premedication. Sleep quality, sedation level, and adverse effects were assessed as secondary outcomes. A total of 231 patients were screened and 224 completed the trial. The mean change (95%CI) in anxiety scores from before to after medication in pregabalin, diazepam, and placebo groups for VNRS were − 0.87 (− 1.43, − 0.30), − 1.17 (− 1.74, − 0.60), and − 0.99 (− 1.56, − 0.41), and for APAIS were − 0.38 (− 1.04, 0.28), − 0.83 (− 1.49, − 0.16), and − 0.27 (− 0.95, 0.40). The difference in change for pregabalin versus diazepam was 0.30 (− 0.50, 1.11) for VNRS and 0.45 (− 0.49, 1.38) for APAIS, exceeding the limit of inferiority for APAIS of 1.3. Sleep quality was statistically different between pregabalin and placebo groups (p = 0.048). Sedation in pregabalin and diazepam groups were significantly higher than placebo group (p = 0.008). No significant differences of other side effects, except dry mouth was higher in placebo group compared with diazepam (p = 0.006). The study filed to provide evidence at non-inferiority of pregabalin compared to diazepam. Furthermore, premedication with either pregabalin or diazepam did not significantly reduce the preoperative anxiety in comparison to placebo, despite the fact that both resulted in higher levels of sedation. Clinicians should weigh the benefits and risks of premedication with these 2 drugs.Thai Clinical Trials Registry: TCTR20190424001 (24/04/2019) Registry URL: https://www.thaiclinicaltrials.org/.

show abstract

Section: Discussionmentioning

confidence: 99%

The anxiolytic effects of preoperative administration of pregabalin in comparison to diazepam and placebo

Nimmaanrat,

Charuenporn,

Jensen

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

Is there a role for pregabalin as premedication in pediatric anesthesia?

2021

View full text Add to dashboard Cite

Where Will Gabapentin’s Bumpy Road Lead us? A Narrative Review of Pediatric Perioperative Gabapentinoids

Li,

2023

Curr Anesthesiol Rep

View full text Add to dashboard Cite

Purpose of Review Gabapentinoids, including gabapentin and pregabalin, have been commonly administered in the perioperative period since opioid-sparing effects were found in adults in the early 2000s. This review examines the current evidence for and against the perioperative use of gabapentinoids in children and identifies potential future directions for research. Recent Findings Many factors led to increasing use of gabapentinoids for surgical patients. The national opioid epidemic hastened the move toward the use of multimodal analgesia and early recovery after surgery protocols for both adults and children. However, subsequent adult studies have found less benefit in postoperative pain reduction than once thought, while others have investigated substantial adverse side effects. The most convincing data supporting the use of pediatric perioperative gabapentinoids show reductions in emergence agitation, postoperative nausea and vomiting (PONV), and chronic persistent surgical pain. Summary As adult trials of perioperative gabapentinoids show decreasing benefits in postoperative pain, opioid consumption, and postoperative nausea and vomiting (PONV) amidst increasing concerns of adverse side effects, benefits for children focus more on reduction in emergence agitation, PONV, and chronic postsurgical pain with more research needed to explore optimal dosing regimens and potential adverse side effects.

show abstract

Efficacy and safety of premedication with single dose of oral pregabalin in children with dental anxiety: A randomized double-blind placebo-controlled crossover clinical trial

Cited by 7 publications

References 22 publications

The anxiolytic effects of preoperative administration of pregabalin in comparison to diazepam and placebo

The anxiolytic effects of preoperative administration of pregabalin in comparison to diazepam and placebo

Is there a role for pregabalin as premedication in pediatric anesthesia?

Where Will Gabapentin’s Bumpy Road Lead us? A Narrative Review of Pediatric Perioperative Gabapentinoids

Contact Info

Product

Resources

About