The anxiolytic effects of preoperative administration of pregabalin in comparison to diazepam and placebo
Sasikaan Nimmaanrat,
Benjalak Charuenporn,
Mark P. Jensen
et al.
Abstract:We aimed to evaluate the potential anxiolytic effects of premedication with pregabalin, compared with diazepam and placebo. We conducted this non-inferiority, double-blind, randomized controlled trial in ASA classification I-II patients aged 18–70 years, scheduled for elective surgery under general anesthesia. They were allocated to receive pregabalin (75 mg the night before surgery and 150 mg 2 h before surgery), diazepam (5 and 10 mg in the same manner) or placebo. Preoperative anxiety was evaluated using ve… Show more
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