Efficacy and safety of platelet-rich plasma in the treatment of severe burns

Chen, Zhao; Wu, Yuyan; Turxun, Nurlan; Shen, Yingjie; Zhang, Xue

doi:10.1097/md.0000000000023001

Cited by 5 publications

(9 citation statements)

References 21 publications

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“…At the same time, it brings inconvenience to the normal social communication of the patients [ 20 , 21 ]. Treatments are divided into general treatment, drug therapy, physiotherapy, and other treatments [ 22 ]. In physiotherapy, photodynamic therapy, red and blue light irradiation, and intense pulsed light have a certain effect on the elimination of acne red marks [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Effect and Safety Analysis of PRP and Yifu Combined with Ultrapulsed CO2 Lattice Laser in Patients with Sunken Acne Scar

Wang

Wang²,

Zhang

et al. 2022

Journal of Healthcare Engineering

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Objective. To investigate the effect and safety of PRP and Yifu combined with ultrapulsed CO2 lattice laser in patients with sunken acne scar. Methods. 700 subjects were selected from the group of patients with sunken acne scar treated in our hospital from November 2010 to December 2020. They were divided into control group (n = 350) and study group (n = 350). The grouping was mainly based on the random number table method. Patients in the control group were treated with ultrapulse CO2 lattice laser, while those in the study group were treated with ultrapulse CO2 lattice laser combined with PRP and Yifu. The clinical effect, scar improvement and quality of life before and after treatment, and adverse events during treatment were compared between the two groups. The clinical effect was categorized into cure after treatment, significant effect, effective, and ineffective. The total effective rate = 1 − ineffective rate. Results. After treatment, the total effective rate of the study group (81.43%) was higher than that of the control group (70.00%). After treatment, ECCA, VSS scores, daily activities, symptoms and feelings, work and study, leisure and entertainment, interpersonal relationship, treatment status, and total scores were all lower in both groups than before treatment, and the study group was lower than the control group. During the treatment, the incidence of adverse events in the study group (17.33%) was lower than that in the control group (28.57%), P < 0.05 . Conclusion. PRP and Yifu combined with ultrapulse CO2 lattice laser in the treatment of sunken acne scar can effectively improve the scar, reduce the incidence of adverse events, and the treatment effect is obvious, which can improve the quality of life of the patients.

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Section: Discussionmentioning

confidence: 99%

Effect and Safety Analysis of PRP and Yifu Combined with Ultrapulsed CO2 Lattice Laser in Patients with Sunken Acne Scar

Wang

Wang²,

Zhang

et al. 2022

Journal of Healthcare Engineering

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“…From the selected clinical trials, three were classified as RCTs [3,35,36] (study ID in Table 1: 3, 10, 11); the other seven studies were classified as CLS [31,[37][38][39][40][41] (study ID in Table 1: 7,13,14,[20][21][22].…”

Section: Systematic Reviewmentioning

confidence: 99%

“…The animals selected in the studies were horses of different age, breed, sex, and attitude; a horse treated with saline solution or with another treatment [35,36] (study ID in Table 1: 10, 11), the contralateral limb of the same animal injected with saline solution [30,44,45,47,48,51] (study ID in 9,12,17), tissue explants incubated with a placebo [3,31,[38][39][40][41] (study ID in Table 1: 3,13,14,[20][21][22], or other affected horses that did not receive any treatment [54] (study ID in Table 1: 23) were used as control groups.…”

Section: Meta-analysismentioning

confidence: 99%

“…The biological effects of PRP include an increase in type I collagen production, the proliferation of tenocytes, neovascularization, increased resistance, and a better organization and alignment of the fibers [ 9 ]. As PRP mechanism of action is still unclear, preparation standards and methods have not been unified, and its clinical efficacy is still controversial [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…Systematic PRP evaluation for repairing tendon and ligament injuries may provide a scientific reference for treatment and clinical application strategies. Indeed, although in human and veterinary medicine several systematic reviews and meta-analyses have been subsequently published [ 3 , 15 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ], it is still not clear which product or combination of substrates is most appropriate related to individual cases. Due to the variety of lesions and products, clinical studies would require large numbers, with economic and ethical concerns [ 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

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The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental Data

Montano

Auletta

Greco³

et al. 2021

Animals

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The use of platelet-rich plasma (PRP) to enhance tenodesmic lesion healing has been questioned over the years. The aim of this study was to evaluate current literature to establish the effectiveness of PRP for treating tenodesmic lesions through a systematic review, in accordance with the PRISMA guidelines, and a meta-analysis. Studies comparing PRP with placebo or other treatments for horses with tenodesmic injuries or evaluated PRP effect on tendon and ligament explants were included. Outcomes were clinical, ultrasound, histologic, molecular evaluation, and adverse effects. Two authors independently extracted data and assessed each study’s risk of bias. Treatment effects were evaluated using risk ratios for dichotomous data, together with 95% CI. Data were pooled using the random-effects model. The quality of the evidence for each outcome was assessed using GRADE criteria. Twenty-four trials met inclusion criteria for systematic review, while fifteen studies were included in the meta-analysis. Results showed no significant differences in the outcomes between PRP and control groups. Finally, there is no definitive evidence that PRP enhances tendons and ligaments healing. Therefore, there is a need for more controlled trials to draw a firmer conclusion about the efficacy of PRP as a treatment for tenodesmic lesions in the horse.

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Role for platelet rich plasma as an adjuvant therapy in wound healing and burns

et al. 2023

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Background Platelet rich plasma (PRP) contains high concentrations of growth factors. Intuitively, these were thought to be of potential benefit in healing of chronic wounds, skin grafts and graft donor sites. This was echoed in retrospective studies and an individual case basis but had not been randomized. Methods A systematic search was carried out by two individuals, independently, on the MEDLINE, EMBASE and COCHRANE databases, according to PRISMA guidelines. All data analysis and statistics was pooled and analysed using the Cochrane RevMan Software. Results Split thickness grafts have been described by numerous authors, but PRP use did not offer a significant advantage in graft take in pooled results (MD 5.83, 95% CI − 0.69 to 12.25, random-effects, p = 0.08). The analysis of included randomized controlled trials has shown favourable split-thickness skin graft donor site healing in the PRP group (MD − 5.55, 95% CI − 7.40 to − 3.69, random-effects, p = < 0.00001) compared to the control group. For carpal tunnel syndrome, the pooled results showed no difference in functional scores vs steroid injections (SMD − 0.68, 95% CI − 1.47 to 0.10, randomeffects, p = 0.09) or indeed splinting groups. Conclusions With the current body of evidence, we conclude that the use of PRP as an adjuvant therapy in skin grafts, burns, carpal tunnel surgery or scars cannot be rationalised. A potential use of PRP is in donor site management but the cost of this would be difficult to justify. Level of evidence: Not ratable.

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Efficacy and safety of platelet-rich plasma in the treatment of severe burns

Cited by 5 publications

References 21 publications

Effect and Safety Analysis of PRP and Yifu Combined with Ultrapulsed CO2 Lattice Laser in Patients with Sunken Acne Scar

Effect and Safety Analysis of PRP and Yifu Combined with Ultrapulsed CO2 Lattice Laser in Patients with Sunken Acne Scar

The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental Data

Role for platelet rich plasma as an adjuvant therapy in wound healing and burns

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