Efficacy and safety of plasma gel as a new modality in treatment of atrophic acne scars

Elfar, Nashwa N.; Hasby, Eiman Adel

doi:10.1111/ijd.14815

Cited by 16 publications

(23 citation statements)

References 16 publications

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“…Among various therapeutic modalities for infraorbital rejuvenation, dermal fillers stand out. Recently, PPP gel has been recommended as a successful autologous dermal filler for facial rejuvenation, 14 acne scars, 17 and chicken pox scars 18 . To date, no previous published report was noticed about its therapeutic efficacy in dark circles.…”

Section: Discussionmentioning

confidence: 99%

Platelet‐poor plasma gel vs platelet‐rich plasma for infraorbital rejuvenation: A clinical and dermoscopic comparative study

Neinaa

Hodeib

Morquos

et al. 2020

Dermatologic Therapy

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Infraorbital dark circles and tear trough deformity are considered common aesthetic problems. Numerous therapeutic modalities have been suggested with variable outcomes. The aim of this study was to compare the efficacy of platelet-poor plasma (PPP) gel vs platelet-rich plasma (PRP) in infraorbital rejuvenation. A total of 68 females presented with dark circles and/or tear trough deformity were recruited and treated by PPP gel injection in the right infraorbital region (Group A) and PRP injection in the left infraorbital region (Group B). They received three treatment sessions at 2-week interval, and followed up monthly for 3 months. They were evaluated clinically and dermoscopically before treatment and at the end of follow-up period. Both groups showed significant clinical improvements proved by significant reduction of degree of hyperpigmentation and tear trough rating scale. Obviously, more significant clinical and dermoscopic improvements were observed in Group A than Group B. Therefore, it could be concluded that both PPP gel and PRP were clinically effective procedures for aesthetic improvement of infraorbital region. Moreover, PPP gel seems to be significantly more effective than PRP as a therapeutic modality.

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Section: Discussionmentioning

confidence: 99%

Platelet‐poor plasma gel vs platelet‐rich plasma for infraorbital rejuvenation: A clinical and dermoscopic comparative study

Neinaa

Hodeib

Morquos

et al. 2020

Dermatologic Therapy

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“…The K3 group had statistically significant differences before and at the beginning of 4 weeks and 3 months after the last session in the degree of acne scarring (P=0.041*, P=0.016*). 21 The results showed a statistically significant difference in the comparison of quantitative acne scars scores between K1 and K2 before and 4 weeks after the last session (P1=0.008*). The K1 group showed better effectiveness in treating acne scars than the K2 group and there was a significant difference.…”

Section: Study Characteristicsmentioning

confidence: 83%

“…Goodman and Baron by Elfar (2020) and Monisha (2021). 21,28 Both studies gave significant results in quantitative reduction in the degree of acne scars (macular, mild, moderate, and severe) with microneedling therapy combined with PRP that could be given as a single therapy, compared to controls given PRP therapy or CO2 fractional laser. The Elfar study (2020) which resulted from the combination of PRP with microneedling obtained a quantitative improvement in the degree of scars according to Goodman and Baron which was much lower than the Monisha study (2021).…”

Section: Discussionmentioning

confidence: 99%

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The Effectiveness of Microneedling Therapy on The Severity of Acne Scars According to Goodman and Baron: A Systematic review and meta-analysis

2022

AJODRR

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Background: The emergence of acne scars due to skin damage in the acne healing process and causes psychological effects. The management of acne scars can be done in several methods. Microneedling is a very simple, safe, effective, and minimally invasive therapeutic technique compared to other therapeutic modalities in acne scars. The resulting wound is micro-sized, and promotes the growth of growth factors and collagen production. We aimed to assess the effectiveness of using microneedling as an acne scar treatment option. A systematic review and meta-analysis were qualitatively and quantitatively conducted from RCTs, assessing the effectiveness of microneedling in reducing the severity of acne scars according to Goodman and Baron in the treatment of acne scars. Methods: Medline Pubmed, PMC, Scopus, Google Scholar, and JDC library, eligible search. Ten studies (n=514) were analyzed qualitatively with 2 studies (n=53 subjects) and quantitatively analyzed by 2 studies (n=90 subjects). Both analyzes were included in the meta-analysis. The mean age of the participants was 40.5 years. The application of microneedling intervention as monotherapy or a combination in patients with acne scarring was followed for at least 16 weeks, the results obtained were the mean reduction in the degree of acne scarring after microneedling. Result: The combination of microneedling treatment obtained a qualitative decrease in the degree of acne scars according to Goodman and Baron with a Z value (-4.299) and P=<0.001 lower than the control (PRP) with a significant difference. The quantitative decrease in the degree of acne scars according to Goodman and Baron obtained a Z value (-4.681) and P=<0.001 lower than the control (PRP) with a significant difference. Quantitative reduction in the degree of acne scars according to Goodman and Baron on single therapy between treatment and control with a value of Z (-3.536) and P=<0.001 lower than control (fractional CO2) with a significant difference. The results of the degree of acne scars in the group treated with microneedling alone or in combination were lower than the control group. The mean before and after therapy compared to the control there was a significant difference. Conclusion. The results of a systematic review, concluded that the group treated with microneedling had a decrease in the degree of acne scarring according to Goodman and Baron with P=<0.001 compared to before treatment. The decrease was shown in the difference in Z values, which was significantly greater than the control given other therapies. Microneedling therapy can be an alternative therapy option for acne scar patients who are unresponsive to previous therapy or in conditions where there are contraindications to other therapies.

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“…They were Elfar and Hasby (15) , who worked with 60 patients who had atrophic post-acne scars. Twenty patients received intradermal injections of plasma gel, twenty patients received derma roller treatment, and twenty patients received both intradermal injections of plasma gel and derma roller treatment.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Atrophic Acne Scars with Platelet Rich Plasma Gel and Micro-needling

Shafik¹,

Nassar²

2021

The Egyptian Journal of Hospital Medicine

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Background: Following the advancements in the treatment of acne, post-acne scarring is still a widespread problem. Platelet-rich plasma (PRP) gel is one formulation with beneficial biological or medicinal qualities that aid in the management of post-acne scarring. Objective: It was the goal of this work to evaluate the utilization of treatment of post-acne scars with micro-needling and plasma gel. Patients and Methods: Patients with post-acne scars were recruited from the university hospital's dermatology and venereology outpatient clinic. Our study was based on 23 patients (8 males= 34.8%, 15 females= 68.2%) having 3 skin types (II, III, IV); skin type III patients representing 56.2% of total patients, most of these patients have scars for less than 10 years. Dermapen has been done to the face then the PRP gel has been applied combined with microneedling to the post-acne scars. We performed four sessions of the previous treatment with two weeks intervals then one month's follow-up. Results: The baron, as well as Goodman scale improvement significantly post-treated with Platelet Rich Plasma Gel Combined with micro-needling, where 69.6% of cases become grade1 post-treatment, drop grade 3 to be (8.7%) post-treatment compared to (47.8%) pre-treatment the difference statistically significant p=0.022. Furthermore, all grade4 fade out post-treatment p=0.008. Conclusion: Dermapen combined with plasma gel is a promising effective therapeutic modality for atrophic acne scars.

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Efficacy and safety of plasma gel as a new modality in treatment of atrophic acne scars

Cited by 16 publications

References 16 publications

Platelet‐poor plasma gel vs platelet‐rich plasma for infraorbital rejuvenation: A clinical and dermoscopic comparative study

Platelet‐poor plasma gel vs platelet‐rich plasma for infraorbital rejuvenation: A clinical and dermoscopic comparative study

The Effectiveness of Microneedling Therapy on The Severity of Acne Scars According to Goodman and Baron: A Systematic review and meta-analysis

Treatment of Atrophic Acne Scars with Platelet Rich Plasma Gel and Micro-needling

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