Efficacy and safety of perilesional/intralesional triamcinolone injections in oral mucous membrane pemphigoid

Kalińska-Bienias, Agnieszka; Kalowska, M.; Kwiek, Bartłomiej; Jakubowska, Beata; Ishii, Norito; Hashimoto, Takashi; Kowaléwski, Cezary; Woźniak, Katarzyna

doi:10.1111/bjd.14043

Cited by 11 publications

(8 citation statements)

References 11 publications

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“…Mild disease is treated with dapsone (50–200 mg/d) for 12 weeks, and if not controlled with dapsone, prednisolone and cyclophosphamide is commenced . Disease limited to the oral mucosa is classified as “low risk” and can be managed with TCS, intralesional triamcinolone, nicotinamide (2–3 g/d), tetracyclines (1–2 g/d) or dapsone (125–150 mg/d) . Prednisolone, azathioprine and MMF can be added in later.…”

Section: Mucous Membrane Pemphigoidmentioning

confidence: 99%

“…65 Disease limited to the oral mucosa is classified as "low risk" and can be managed with TCS, intralesional triamcinolone, nicotinamide (2-3 g/d), tetracyclines (1-2 g/d) or dapsone (125-150 mg/d). 65,76 Prednisolone, azathioprine and MMF can be added in later. Ocular MMP responds rapidly to rituximab, though additional cycles may be required.…”

Section: Mucous Membrane Pemphigoidmentioning

confidence: 99%

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Review of autoimmune blistering diseases: the Pemphigoid diseases

Daniel

Murrell

2019

Acad Dermatol Venereol

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Autoimmune Blistering Diseases of the Pemphigoid type is characterised by sub‐epidermal blisters (SEB) with circulating autoantibodies against components of the basement membrane zone (BMZ). The main disorders to date include bullous pemphigoid (BP), pemphigoid gestationis, mucous membrane pemphigoid (MMP), epidermolysis bullosa acquisita (EBA), linear IgA disease (LABD), dermatitis herpetiformis (DH), lichen planus pemphigoides and bullous lupus. This is in contrast to pemphigus and related disorders, which demonstrate intraepidermal acantholysis and a positive Nikolsky sign. The classification and management is based on clinical, histological and direct and indirect immunofluorescence findings. There are, however, overlapping clinical and histological features between the conditions and clinical heterogeneity within each disease.

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Section: Mucous Membrane Pemphigoidmentioning

confidence: 99%

Section: Mucous Membrane Pemphigoidmentioning

confidence: 99%

Review of autoimmune blistering diseases: the Pemphigoid diseases

Daniel

Murrell

2019

Acad Dermatol Venereol

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“…The ICSI in these lesions is not recommended during relapse/flare periods due to inadequate effects. It seems that the given method is the most effective one in the maintenance phase; as more than 70% of the lesions are improved and the systemic corticosteroid is getting tapered (Fortuna & Mignogna, 2011;Mignogna et al, 2010;Nguyen & Ahmed, 2014;Abbas et al, 2014;Kalinska-Bienias et al, 2016). In this respect, a study in 2018 demonstrated that the ICSI in combination with immunosuppressive drugs could lead to reduced dose of corticosteroids and shortened time of clinical improvements (Mignogna et al, 2010).…”

Section: Vesiculobullous Disordermentioning

confidence: 99%

Intralesional corticosteroid injection as an effective treatment method for oral lesions: a meta-analysis

Gholizadeh

Sadrzadeh-Afshar

Sheykhbahaei

2020

Braz. J. Pharm. Sci.

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Intralesional corticosteroid injection (ICSI) is known as one of the main methods used for treating a wide range of lesions. It also results in a high concentration of drugs at lesion sites, with minimal systemic absorption. Thus, this study aimed to provide a review of the intralesional corticosteroid injection (ICSI) indications in the treatment of oral lesions. To this end; relevant key words were searched in the databases of PubMed, Google Scholar, Scopus, ScienceDirect, and UpToDate in the present study. Accordingly, the results of a total number of 62 case reports or case series articles were used in this study and the positive therapeutic effects of intralesional corticosteroid injection (ICSI) in 23 common oral lesions were reported. The most common type of intralesional steroid in the treatment of oral lesions was triamcinolone. No significant difference was also observed in terms of pain in patients following the use of steroid alone or in combination with anesthetic agents; moreover, the reported side effects of this method were exceptionally rare and transient. It was concluded that the intralesional corticosteroid injection (ICSI) could be one of the effective therapeutic methods with no significant problems in many oral lesions such as inflammatory, immunologic, and vascular ones due to its higher therapeutic effects than other topical forms of steroids and fewer side effects than systemic corticosteroid.

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“…When it affects the gingiva, it is referred to as "desquamative gingivitis". MMP is the most common group of autoimmune mucocutaneous diseases that affects the oral cavity [1][2][3] .…”

Section: Introductionmentioning

confidence: 99%

“…MMP can affect various mucous membranes but predominantly occurs in the oral cavity. In most of cases oral lesions may be initial manifestation or the only sign of the disease [2,3,7] .…”

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confidence: 99%

Localized Oral Mucous Membrane Pemphigoid: Successful Treatment with Intralesional Triamcinolone Acetonide Injection

Erbaşar¹

2016

JDOC

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Mucous membrane pemphigoid (MMP) is a rare, chronic and vesiculobullous disorder that classified as autoimmune disease.MMP can affect various mucous membranes but predominantly occurs in the oral cavity. In most of cases oral lesions may be initial manifestation or the only sign of the disease. It is predominantly seen in the fifth decade of life. It affects women more commonly than men. Children are rarely affected from this disease. MMP may cause extremely variable severity due to different clinical presentations as vesicles, erosions, pain, and occasional scarring. Oral lesions as gingival inflammation and scarring are not life theatening but lead to functional limitations. The primary goals of the treatment are to cease the progression of the disease, reduce the symptoms, and prevent the sequelae of tissue ulseration and consecutive scarring. The mild MMP lesions may be successfully managed with topical corticosteroids. However, the lesions that do not respond to local treatments or become widespread and also the diseases which show rapid progress can be treated can be treated with systemic glucocorticoids and immunosuppressive agents such as azathioprine, mycophenolatemofetyl, cyclosporine, and dapsone, rituximab and intravenous immunoglobulin. In this report two cases of oral MMP treated successfully with intralesional triamcinolone acetonide are presented along with a review of literature.

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Efficacy and safety of perilesional/intralesional triamcinolone injections in oral mucous membrane pemphigoid

Cited by 11 publications

References 11 publications

Review of autoimmune blistering diseases: the Pemphigoid diseases

Review of autoimmune blistering diseases: the Pemphigoid diseases

Intralesional corticosteroid injection as an effective treatment method for oral lesions: a meta-analysis

Localized Oral Mucous Membrane Pemphigoid: Successful Treatment with Intralesional Triamcinolone Acetonide Injection

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