Localized Oral Mucous Membrane Pemphigoid: Successful Treatment with Intralesional Triamcinolone Acetonide Injection

Abstract

Mucous membrane pemphigoid (MMP) is a rare, chronic and vesiculobullous disorder that classified as autoimmune disease.MMP can affect various mucous membranes but predominantly occurs in the oral cavity. In most of cases oral lesions may be initial manifestation or the only sign of the disease. It is predominantly seen in the fifth decade of life. It affects women more commonly than men. Children are rarely affected from this disease. MMP may cause extremely variable severity due to different clinical presentations as vesicles, erosions, pain, and occasional scarring. Oral lesions as gingival inflammation and scarring are not life theatening but lead to functional limitations. The primary goals of the treatment are to cease the progression of the disease, reduce the symptoms, and prevent the sequelae of tissue ulseration and consecutive scarring. The mild MMP lesions may be successfully managed with topical corticosteroids. However, the lesions that do not respond to local treatments or become widespread and also the diseases which show rapid progress can be treated can be treated with systemic glucocorticoids and immunosuppressive agents such as azathioprine, mycophenolatemofetyl, cyclosporine, and dapsone, rituximab and intravenous immunoglobulin. In this report two cases of oral MMP treated successfully with intralesional triamcinolone acetonide are presented along with a review of literature.