Efficacy and safety of oral iron(III) polymaltose complex versus ferrous sulfate in pregnant women with iron-deficiency anemia: a multicenter, randomized, controlled study

Abstract

Oral iron(III) polymaltose complex offers at least equivalent efficacy and a superior safety profile compared to ferrous sulfate for the treatment of iron-deficiency anemia during pregnancy.

Iron deficiency anemia in pregnancy

“…Various authors have postulated that iron polymaltose complexes have lower toxicity compared with iron sulfate salts, due to reduced formation of oxygen radicals and thus decreased plasma lipid peroxidation. In studies carried out to date, their bioavailability is comparable with that of iron (II) sulfates and fumarates [43].…”

“…However, it must be pointed out that the numbers of treated patients were low in all studies [14,33,40,[43][44][45][46][49][50][51][52][53].…”

International Forum regarding practices related to donor haemoglobin and iron

“…Compliance and adverse effects are not routinely monitored since only a short oral course is provided to most donors, and the ferric polymaltose complex formulation in current use has been shown to have a lower risk of gastrointestinal side effects compared to ferrous compounds .…”

Current information about iron deficiency anemia in pregnancy: Iron supplementation for whom? When? How much?

“…Bu preparatın demir (II) tuzlarına göre avantajları; yavaş salınıma bağlı olarak yan etkisi daha az, yemekle birlikte alınabilir, toksitesi daha az ve biyoyararlanımı demir (II) tuzlarına yakındır. Parenteral Demir Tedavisi IV demir kullanım endikasyonları: Oral demire yetersiz veya hiç cevap vermeyen vakalar, ağır anemi, yetersiz emilim (ince barsak hastalığına bağlı), inflamatuar bağırsak hastalığı, kronik böbrek hastalığı, kanser hastaları, aneminin hızlı bir şekilde düzeltilmesi ihtiyacı, oral demire karşı intolerans, hastanın oral tedaviye uyumunun olmaması (kötü kompliyans), kanamanın devam ettiği (kan kaybı gastrointestinal sistemden emilen miktarın üzerindedir) durumlardır (34). Oral verilen demirden günlük maksimum 25 mg emilebilmesine rağmen parenteral tek dozda 1000 mg demir infüzyon ile verilebilmektedir.…”