Efficacy and safety of oral desensitization in children with cow's milk allergy according to their serum specific IgE level

García-Ara, Carmen; Pedrosa, María; Belver, María Teresa; Martín-Muñoz, M.F.; Quirce, Santiago; Boyano-Martínez, Teresa

doi:10.1016/j.anai.2013.01.013

Cited by 34 publications

(45 citation statements)

References 18 publications

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“…12,13 Critical to the success and safety of an OIT program is true accurate reporting of reactions occurring during the home treatment phase. The reaction history, severity, and treatment required each are factors influencing the need for protocol modification 12,15,22,28 and potentially aborting a specific patient's OIT treatment. 33,38 Furthermore, this information could assist in identifying potential triggers predisposing to home reactions, leading to safety improvements of the home maintenance phase.…”

Section: Introductionmentioning

confidence: 99%

A Web site–based reporting system for monitoring home treatment during oral immunotherapy for food allergy

Nachshon

Goldberg

Elizur

et al. 2015

Annals of Allergy, Asthma & Immunology

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Section: Introductionmentioning

confidence: 99%

A Web site–based reporting system for monitoring home treatment during oral immunotherapy for food allergy

Nachshon

Goldberg

Elizur

et al. 2015

Annals of Allergy, Asthma & Immunology

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“…García-Ara et al evaluated the efficacy and safety of an OIT protocol according to the level of sIgE. They found that the lower the sIgE level at baseline, the earlier tolerance was achieved, and that adverse effects were more frequent when sIgE levels were higher 96. Vázquez-Ortiz et al identified three variables associated with reaction persistence throughout the OIT: cow milk-sIgE levels of at least 50 kUA/L, SPT wheal size of ≥9 mm and Sampson severity grades 2, 3 and 4 at baseline food challenge 97…”

Section: Methodsmentioning

confidence: 99%

Diagnosis and management of food allergies: new and emerging options: a systematic review

O’Keefe¹,

Schryver²,

Mill³

et al. 2014

JAA

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It is reported that 6% of children and 3% of adults have food allergies, with studies suggesting increased prevalence worldwide over the last few decades. Despite this, our diagnostic capabilities and techniques for managing patients with food allergies remain limited. We have conducted a systematic review of literature published within the last 5 years on the diagnosis and management of food allergies. While the gold standard for diagnosis remains the double-blind, placebo-controlled food challenge, this assessment is resource intensive and impractical in most clinical situations. In an effort to reduce the need for the double-blind, placebo-controlled food challenge, several risk-stratifying tests are employed, namely skin prick testing, measurement of serum-specific immunoglobulin E levels, component testing, and open food challenges. Management of food allergies typically involves allergen avoidance and carrying an epinephrine autoinjector. Clinical research trials of oral immunotherapy for some foods, including peanut, milk, egg, and peach, are under way. While oral immunotherapy is promising, its readiness for clinical application is controversial. In this review, we assess the latest studies published on the above diagnostic and management modalities, as well as novel strategies in the diagnosis and management of food allergy.

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“…For example, baseline serum specific IgE levels may help predict the safety of OIT and assess patient's candidacy for such treatments [42]. In another study, lower levels of serum specific and component IgE were associated with successful desensitization in peanut SLIT as well [43].…”

Section: Personalized Approach To Food Desensitizationmentioning

confidence: 98%

Emerging Approaches to Food Desensitization in Children

Hamad

Burks

2017

Curr Allergy Asthma Rep

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Recent advancements in epicutaneous, sublingual, and oral immunotherapy for food allergy in the future may offer children with food allergy and their families a viable option to reduce risk or severity of anaphylaxis with phase III trials ongoing for two of these treatment modalities. Food allergy prevalence in children is estimated to be up to 8%. These children are at risk of significant allergic reactions and anaphylaxis. Food avoidance and use of antihistamines or epinephrine has been the standard of care for these patients. This approach also has a significant socioeconomic effects on patients and their families. Recent advancements in understanding food allergy have allowed for exploring new methods of treatment. There is an increasing interest in oral immunotherapy, epicutaneous immunotherapy, or sublingual immunotherapy for food allergy. There have been also innovative approaches to immunotherapy by modification of food allergens (to make them less allergenic while maintain their immunogenicity) or adding adjunctive treatments (probiotics, anti-IgE, etc.) to increase efficacy or safety.

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Efficacy and safety of oral desensitization in children with cow's milk allergy according to their serum specific IgE level

Cited by 34 publications

References 18 publications

A Web site–based reporting system for monitoring home treatment during oral immunotherapy for food allergy

A Web site–based reporting system for monitoring home treatment during oral immunotherapy for food allergy

Diagnosis and management of food allergies: new and emerging options: a systematic review

Emerging Approaches to Food Desensitization in Children

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