Diagnosis and management of food allergies: new and emerging options: a systematic review

O’Keefe, Andrew; Schryver, Sarah De; Mill, Jennifer; Mill, Christopher; Dery, Alizée; Ben‐Shoshan, Moshe

doi:10.2147/jaa.s49277

Cited by 16 publications

(6 citation statements)

References 116 publications

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“…Food allergens are naturally occurring proteins present in a multitude of foods. Individuals with a food allergy are sensitized towards these proteins, and exposure to them can lead to adverse, sometimes life-threatening, health effects [1]. The majority of food allergen-related anaphylaxis in Europe can be attributed to peanut and tree nut allergens [2].…”

Section: Introductionmentioning

confidence: 99%

A Critical Comparison between Flow-through and Lateral Flow Immunoassay Formats for Visual and Smartphone-Based Multiplex Allergen Detection

2019

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(1) Background: The lack of globally standardized allergen labeling legislation necessitates consumer-focused multiplexed testing devices. These should be easy to operate, fast, sensitive and robust. (2) Methods: Herein, we describe the development of three different formats for multiplexed food allergen detection, namely active and passive flow-through assays, and lateral flow immunoassays with different test line configurations. (3) Results: The fastest assay time was 1 min, whereas even the slowest assay was within 10 min. With the passive flow approach, the limits of detection (LOD) of 0.1 and 0.5 ppm for total hazelnut protein (THP) and total peanut protein (TPP) in spiked buffer were reached, or 1 and 5 ppm of THP and TPP spiked into matrix. In comparison, the active flow approach reached LODs of 0.05 ppm for both analytes in buffer and 0.5 and 1 ppm of THP and TPP spiked into matrix. The optimized LFIA configuration reached LODs of 0.1 and 0.5 ppm of THP and TPP spiked into buffer or 0.5 ppm for both analytes spiked into matrix. The optimized LFIA was validated by testing in 20 different blank and spiked matrices. Using device-independent color space for smartphone analysis, two different smartphone models were used for the analysis of optimized assays.

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Section: Introductionmentioning

confidence: 99%

A Critical Comparison between Flow-through and Lateral Flow Immunoassay Formats for Visual and Smartphone-Based Multiplex Allergen Detection

2019

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“…The present study has some limitations that should be taken into consideration. It is well known that self-reported food intolerance yield a much higher prevalence compared to prevalence from performed food challenges and IgE data for food allergies [ 45 ]. However, the comparison between asthmatics and non-asthmatics should still be valid, since we have no reason to believe that the self-reporting accuracy differs between these two groups.…”

Section: Discussionmentioning

confidence: 99%

Self‐reported adverse reactions and IgE sensitization to common foods in adults with asthma

Rentzos¹,

Johanson²,

Sjölander³

et al. 2015

Clinical & Translational All

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BackgroundThere is very few data available on the prevalence of food hypersensitivity among adults with asthma. The aim of this study was to explore the prevalence of self-reported adverse reactions and IgE sensitization to the different foods and to determine the spectrum and the prevalence of food-related gastrointestinal symptoms in adults with and with no asthma.MethodsA cross sectional study based on interviews and questionnaire responses from 1527 subjects, aged 18–75 years of age, from Västra Götaland in Sweden, as part of the larger West Sweden Asthma Study. IgE analyses were performed in sera from all subjects.ResultsFifty three percent of adults with asthma reported adverse reactions to foods compared to 30 % of non-asthmatics. Most asthmatics reported symptoms from eating hazelnut, followed by other nuts, birch-related foods, milk, peanut and shellfish. Furthermore, adults with asthma experienced significantly more often gastrointestinal symptoms from hazelnut, apple and milk and were found to significantly more often be sensitized to the most common foods compared to the non-asthmatic subjects. The asthmatics showed a significant correlation between IgE to both hazelnut and birch and self-reported symptoms after ingestion of hazelnut and to a lesser extent to almonds.ConclusionsThe prevalence of self-reported adverse reactions and sensitization to the most common foods was much higher among the asthmatic subjects. Hazelnut was the food that asthmatics most frequently experienced adverse reactions from, and the strong correlation between IgE to hazelnut and birch indicate that the observed adverse reactions are partly due to sensitization to allergens from the PR-10 family.Electronic supplementary materialThe online version of this article (doi:10.1186/s13601-015-0067-6) contains supplementary material, which is available to authorized users.

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“…Rice crackers and hummus were the suspected foods and therefore several potential allergens were investigated based on their ingredients: wheat, rice, soy oil, sesame, and chickpeas. There was no previous history of food allergy to any of these food items and SPT, given its high sensitivity, excluded wheat, rice, and sesame allergy [ 12 ]. The extracts prepared from the actual food products were helpful in excluding the cracker, which contained soy oil.…”

Section: Discussionmentioning

confidence: 99%

Food-dependent exercise-induced anaphylaxis to chickpea in a 17-year-old female: a case report

Roberts

Ben‐Shoshan

2015

J Med Case Reports

Self Cite

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IntroductionFood-dependent exercise-induced anaphylaxis is a subtype of anaphylaxis and, although rare, it is an important condition to be familiar with as it can ultimately lead to death.Case presentationWe present a case of food-dependent exercise-induced anaphylaxis in a 17-year-old white girl due to chickpea. She had a history of anaphylaxis after eating crackers and hummus before exercising. Skin prick testing and serum-specific immunoglobulin E level confirmed chickpea to be the causative allergen.ConclusionsThis case demonstrates the challenge in identifying specific causative food allergens when foods are eaten in combination, when the food is processed, and when cross-reactivity is possible. These challenges add complexity to a condition that is already rare and unfamiliar to some health care providers. We hope that this case will serve as an important reminder that although rare, food-dependent exercise-induced anaphylaxis exists and making a diagnosis can lead to life-saving preventative strategies. As legumes are not a common food associated with food-dependent exercise-induced anaphylaxis, this will add to our current knowledge base in the field of allergy.

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Diagnosis and management of food allergies: new and emerging options: a systematic review

Cited by 16 publications

References 116 publications

A Critical Comparison between Flow-through and Lateral Flow Immunoassay Formats for Visual and Smartphone-Based Multiplex Allergen Detection

A Critical Comparison between Flow-through and Lateral Flow Immunoassay Formats for Visual and Smartphone-Based Multiplex Allergen Detection

Self‐reported adverse reactions and IgE sensitization to common foods in adults with asthma

Food-dependent exercise-induced anaphylaxis to chickpea in a 17-year-old female: a case report

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