Efficacy and safety of low-level light therapy by delicate pulsed light combined with low-dose oral isotretinoin for the treatment of acne vulgaris: a randomized split-face study

Li, Youbao; Xia, Jun; Zhu, Yu; He, Shujuan; Liu, Jing; Zeng, Weihui; Wang, Zhao

doi:10.1007/s10103-022-03606-z

Cited by 7 publications

(12 citation statements)

References 40 publications

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“…Although keloid formation was the concern when isotretinoin was applied, 33,34 multiple studies reported that low dose isotretinoin is a safe option in recent years. 25,[35][36][37] No hypertrophic scars or keloids were observed in our study. Moreover, no hyperpigmentation or hypopigmentation occurred.…”

Section: Discussioncontrasting

confidence: 47%

“…Compared with FxPico alone, the combined therapy has a more obvious effect on the improvement of acne scar and lesions. Although keloid formation was the concern when isotretinoin was applied, 33,34 multiple studies reported that low dose isotretinoin is a safe option in recent years 25,35–37 . No hypertrophic scars or keloids were observed in our study.…”

Section: Discussionmentioning

confidence: 42%

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Efficacy and safety of low‐dose oral isotretinoin monotherapy versus combined therapy with picosecond laser for the treatment of acne scars in Asian population

Xue

Huang

et al. 2023

Lasers Surg Med

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Purpose Acne scars are common in patients with moderate to severe acne. Isotretinoin is the first‐line treatment for those patients, but whether oral isotretinoin can improve acne scar is not clear. Picosecond lasers (FxPico) has been reported to improve acne scars. In the present study, we evaluated the clinical efficacy of low‐dose isotretinoin with or without FxPico treatment for acne scars. Materials and Methods A total of 48 patients with acne scars were enrolled and were randomly assigned to receive low dose oral isotretinoin or not. For all the patients in both treatment groups, one side of face were randomly assigned to be treated with picosecond laser. Assessments, including photos, échelle d'évaluation clinique des cicatrices d'acné (ECCA) and Global Acne Grading System (GAGS) score, the number of lesions, melanin and erythema indexes, transepidermal water loss were assessed at 0, 1, 2, and 3 month. Side effects, Dermatology Life Quality Index (DLQI) and satisfaction were recorded before and after the study. Results A total of 44 patients completed the study (24 received oral low dose isotretinoin and 20 did not). Low dose oral isotretinoin treated group showed significant improvement on ECCA (from 112.5 [50–180] to 105 [50–160]), GAGS score (from 12.6 ± 3.3 to 10.1 ± 3.0), the count of papules (from 4.3 ± 3.7 to 1.0 ± 1.5) than the blank group, and higher improvement were noticed after isotretinoin combined with FxPico. All the side effects were temporary and tolerable, no adverse effects were observed. Higher DLQI and patients' satisfaction were achieved by oral isotretinoin alone and isotretinoin combined with FxPico. Conclusions This is the first paper showing the improvement of scars by early low dose‐isotretinoin intervention with or without the combination of picosecond laser. Early intervention with oral low‐dose isotretinoin is effective for the treatment and prevention of acne scars, the combined therapy with FxPico can achieve better outcome.

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Section: Discussioncontrasting

confidence: 47%

Section: Discussionmentioning

confidence: 42%

Efficacy and safety of low‐dose oral isotretinoin monotherapy versus combined therapy with picosecond laser for the treatment of acne scars in Asian population

Xue

Huang

et al. 2023

Lasers Surg Med

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“…The mean reduction rate of this study compared with other reported clinical trials. It is obvious that the treatment of this study is more efficient while costing less time 24–39 …”

Section: Resultsmentioning

confidence: 93%

“…Compared with 30% SSA, no matter other chemical exfoliators or traditional molecular formation of salicylic acid, the comedone reduction rate was still lower. The reduction rate of 40% pyruvic acid was 38.64% in 24 weeks, that of 25% trichloroacetic acid was 53.91% in 12 weeks, and two lectures reported about the traditional molecular formation of salicylic acid treating AV, whose comedone reduction rate were 56% and 53.71% 24–39 …”

Section: Resultsmentioning

confidence: 99%

“…In contrast to previous studies, we found that the synergy of CO 2 laser and SSA in the treatment of comedones can achieve a higher and faster lesion reduction, dealing with the efficacy‐time conflict, that achieves better effects in reducing comedones by 85.9% in 12 weeks, outperforming the reported clinical trials on comedones or AV (Figure 7). 24–39 …”

Section: Discussionmentioning

confidence: 99%

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Combining superpulse dynamic CO₂ laser and supramolecular salicylic acid in the treatment of dense comedones with higher clearance in a shorter time: A prospective, randomized, split‐face clinical trial

et al. 2023

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ObjectivesDense comedones are common in patients with acne vulgaris, and promoting treatment can prevent the progression of acne lesions. However, the efficacy‐time conflict makes the treatment challenging and the medication options are limited by the side effects.Materials and methodsThirty‐five patients with symmetrical dense comedones were enrolled and the two sides of the face were randomly assigned to receive 30% supramolecular salicylic acid (SSA) combined with CO2 laser or CO2 laser monotherapy at an interval of 2 weeks for six treatment sessions. Comedones count, porphyrin index (PI), texture index (TI), melanin index, erythema index, hydration index (HI), transepidermal water loss (TEWL), and side effects were recorded at each visit till the 12th week.ResultsThirty‐one patients completed the study. Comedones on the combined‐SSA side were reduced more after six treatments, that the mean reduction rate of the combined‐SSA side was 85.76%, and that of the CO2 laser‐treated side was 62.32% (Pbetween < 0.001). Combining SSA also showed a better effect on reducing PI and TI than CO2 laser singly (Pbetween < 0.001). TEWL and HI between the two sides showed no significant differences after treatments. No permanent or severe side effects were observed on both side.ConclusionsThe treatment combined CO2 laser with 30% SSA dealt with the efficacy‐time conflict while significantly reducing comedones and improving skin texture in 12 weeks and no serious adverse reactions occurred.LimitationsIt is a single‐center study and the number of subjects was small.

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Early acne scar intervention with 1064 nm picosecond laser in patients receiving oral isotretinoin: a randomized split-face controlled pilot study

Xue

Huang

et al. 2023

Lasers Med Sci

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Efficacy and safety of low-level light therapy by delicate pulsed light combined with low-dose oral isotretinoin for the treatment of acne vulgaris: a randomized split-face study

Cited by 7 publications

References 40 publications

Efficacy and safety of low‐dose oral isotretinoin monotherapy versus combined therapy with picosecond laser for the treatment of acne scars in Asian population

Efficacy and safety of low‐dose oral isotretinoin monotherapy versus combined therapy with picosecond laser for the treatment of acne scars in Asian population

Combining superpulse dynamic CO₂ laser and supramolecular salicylic acid in the treatment of dense comedones with higher clearance in a shorter time: A prospective, randomized, split‐face clinical trial

Early acne scar intervention with 1064 nm picosecond laser in patients receiving oral isotretinoin: a randomized split-face controlled pilot study

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Efficacy and safety of low-level light therapy by delicate pulsed light combined with low-dose oral isotretinoin for the treatment of acne vulgaris: a randomized split-face study

Cited by 7 publications

References 40 publications

Efficacy and safety of low‐dose oral isotretinoin monotherapy versus combined therapy with picosecond laser for the treatment of acne scars in Asian population

Efficacy and safety of low‐dose oral isotretinoin monotherapy versus combined therapy with picosecond laser for the treatment of acne scars in Asian population

Combining superpulse dynamic CO2 laser and supramolecular salicylic acid in the treatment of dense comedones with higher clearance in a shorter time: A prospective, randomized, split‐face clinical trial

Early acne scar intervention with 1064 nm picosecond laser in patients receiving oral isotretinoin: a randomized split-face controlled pilot study

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Combining superpulse dynamic CO₂ laser and supramolecular salicylic acid in the treatment of dense comedones with higher clearance in a shorter time: A prospective, randomized, split‐face clinical trial