Efficacy and Safety of Intravenous Ferric Carboxymaltose in Patients with Postoperative Anemia Following Same-Day Bilateral Total Knee Arthroplasty: A Randomized Controlled Trial

Kim, Man Soo; Koh, In Jun; Choi, Keun Young; Yang, Sung Cheol; In, Yong

doi:10.3390/jcm10071457

Cited by 7 publications

(13 citation statements)

References 44 publications

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“…There are still controversies regarding postoperative iron administration. Most studies evaluate preopera- There are some studies about postoperative intravenous iron agents' use with good outcomes regarding haemoglobin and iron status at 4-weeks follow-up in major elective surgery [36], improved haemoglobin level at two weeks after major orthopaedic surgery [37]. In contrast, some reports found that postoperative iron administration does not significantly correct haemoglobin level or influence the transfusion rate [38].…”

Section: Discussionmentioning

confidence: 99%

The Importance of Iron Administration in Correcting Anaemia after Major Surgery

Ţigliş

Cobilinschi

Mirea

et al. 2021

The Journal of Critical Care Medicine

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Introduction: Postoperative anaemia can affect more than 90% of patients undergoing major surgeries. Patients develop an absolute iron deficiency in the face of significant blood loss or preoperative anaemia and major surgery. Studies have shown the negative impact of these factors on transfusion requirements, infections, increased hospitalisation and long-term morbidities. Aim of the study: The research was performed to determine the correlation between intravenous iron administration in the postoperative period and improved haemoglobin correction trend. Material and methods: A prospective study was conducted to screen and treat iron deficiency in patients undergoing major surgery associated with significant bleeding. For iron deficiency anaemia screening, in the postoperative period, the following bioumoral parameters were assessed: haemoglobin, serum iron, transferrin saturation (TSAT), and ferritin, direct serum total iron-binding capacity (dTIBC), mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH). In addition, serum glucose, fibrinogen, urea, creatinine and lactate values were also collected. Results: Twenty-one patients undergoing major surgeries (52,38% were emergency and 47,61% elective interventions) were included in the study. Iron deficiency, as defined by ferritin 100-300 μg/L along with transferrin saturation (TSAT) < 20 %, mean corpuscular volume (MVC) < 92 fL, mean corpuscular haemoglobin (MCH) < 33 g/dL, serum iron < 10 μmol/L and direct serum total iron-binding capacity (dTIBC) > 36 μmol/L, was identified in all cases. To correct the deficit and optimise the haematological status, all patients received intravenous ferric carboxymaltose (500-1000 mg, single dose). Using Quadratic statistical analysis, the trend of haemoglobin correction was found to be a favourable one. Conclusion: The administration of intravenous ferric carboxymaltose in the postoperative period showed the beneficial effect of this type of intervention on the haemoglobin correction trend in these groups of patients.

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Section: Discussionmentioning

confidence: 99%

The Importance of Iron Administration in Correcting Anaemia after Major Surgery

Ţigliş

Cobilinschi

Mirea

et al. 2021

The Journal of Critical Care Medicine

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“…In total, 118 patients received iron or placebo shortly after total knee arthroplasty. Iron supplementation resulted in significantly higher levels of Hb, ferritin, iron, and transferrin saturation 2–12 weeks after surgery [31 ▪ ]. None of these RCTs detected a rise in adverse events or mortality upon intravenous iron administration.…”

Section: Anaemia Management In Intensive Care Patientsmentioning

confidence: 95%

Patient Blood Management in intensive care patients

Hof

Choorapoikayil

Meybohm

et al. 2021

Current Opinion in Critical Care

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Purpose of reviewPatients admitted to ICUs are a heterogeneous group, displaying multiple anaemia risk factors and comorbidities. Clinicians should therefore take all possible measures to identify modifiable risks. Patient Blood Management (PBM) is an approach promoting the timely application of evidence-based interventions designed to maintain patients own blood mass.Recent findingsWithin ICU-patients, anaemia is highly prevalent. Generally, anaemia is associated with impaired outcome and need of blood transfusion. Currently, with ICUs working at full capacity and the global blood reserves exhausted, the SARS-CoV-2 pandemic reinforces the need for PBM implementation. For instance, implementation of a comprehensive coagulation management and measures to avoid iatrogenic blood loss may prevent bleeding-associated complications and adherence to blood transfusion guidelines may reduce adverse events associated with transfusion.SummaryCritically ill patients display various morbidities often requiring individualized treatment. PBM offers patient-centred measures to improve outcome any time during hospital stay.

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“…Eisengaben bei 118 orthopädischen Patienten [25]. Die Eisengabe führte zu signifikant höheren Hb-Werten 2-12 Wochen nach der Operation.…”

Section: Kim Et Al Untersuchten Den Effekt Von Postoperativen I Vunclassified

Patient Blood Management in der Intensivmedizin

Hof¹,

Choorapoikayil²,

Old³

et al. 2023

Intensivmedizin up2date

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Anämien sind mit erhöhtem Transfusionsbedarf und vermehrten Komplikationen inklusive erhöhter Sterblichkeit assoziiert. Aufgrund von Entzündungen, Koagulopathien und Blutungen, iatrogenen Blutverlusten und anderen Einflussfaktoren weisen Intensivpatienten eine hohe Anämieprävalenz auf. Patient Blood Management (PBM) ist ein Konzept, das (perioperatives) Anämiemanagement, die Reduktion von Blutverlusten und den evidenzbasierten Einsatz von Bluttransfusionen fördert und Eingang in diverse Guidelines gefunden hat. Entsprechend würden Intensivpatienten von PBM enorm profitieren.

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Efficacy and Safety of Intravenous Ferric Carboxymaltose in Patients with Postoperative Anemia Following Same-Day Bilateral Total Knee Arthroplasty: A Randomized Controlled Trial

Cited by 7 publications

References 44 publications

The Importance of Iron Administration in Correcting Anaemia after Major Surgery

The Importance of Iron Administration in Correcting Anaemia after Major Surgery

Patient Blood Management in intensive care patients

Patient Blood Management in der Intensivmedizin

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