Efficacy and Safety of Intense Pulsed Light in Treatment of Melasma in Chinese Patients

Li, Yuanhong; Chen, John Z S; Wei, Huachen; Wu, Yan; Liu, Mei; Xu, Yuanyuan; Dong, Guang‐Hui; Chen, Hong‐Duo

doi:10.1111/j.1524-4725.2008.34130.x

Cited by 79 publications

(61 citation statements)

References 20 publications

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“…Li et al [23] studied the efficacy and safety of an IPL device (Lumenis One, Lumenis, Inc., Santa Clara, CA; fluence: 13-17 J/cm 2 ; 560-/590-nm filters, double pulse or 590-/615-/640-nm filters and triple pulse, 3-4 milliseconds pulse duration; 25-40 milliseconds pulse delay) in the treatment of melasma in Chinese patients (n ¼ 89). Patients received IPL treatments (n ¼ 4) at 3-week intervals.…”

Section: Pigmented Lesionsmentioning

confidence: 99%

Intense pulsed light (IPL): A review

et al. 2010

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Background: Intense pulsed light (IPL) devices use flashlamps and bandpass filters to emit polychromatic incoherent high-intensity pulsed light of determined wavelength spectrum, fluence, and pulse duration. Similar to lasers, the basic principle of IPL devices is a more or less selective thermal damage of the target. The combination of prescribed wavelengths, fluences, pulse durations, and pulse intervals facilitates the treatment of a wide spectrum of skin conditions. Objective: To summarize the physics of IPL, to provide guidance for the practical use of IPL devices, and to discuss the current literature on IPL in the treatment of unwanted hair growth, vascular lesions, pigmented lesions, acne vulgaris, and photodamaged skin and as a light source for PDT and skin rejuvenation. Methods: A systematic search of several electronic databases, including Medline and PubMed and the authors experience on intense pulsed light. Results: Numerous trials show the effectiveness and compatibility of IPL devices. Conclusion: Most comparative trials attest IPLs similar effectiveness to lasers (level of evidence: 2b to 4, depending on the indication). However, large controlled and blinded comparative trials with an extended follow-up period are necessary. Lasers Surg. Med. 42:93-104, 2010.

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Section: Pigmented Lesionsmentioning

confidence: 99%

Intense pulsed light (IPL): A review

et al. 2010

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“…Over the last decade, the demand for IPL therapy in treating melasma has risen steadily, although IPL was traditionally considered as a second-line treatment. Li reported that 69 of 89 Chinese patients (77.5%) being treated for melasma improved by more than 50% following a total of four IPL treatments at 3-week intervals [12]. Recently, low-fluence IPL and fractionated IPL were used in treating melasma.…”

Section: Pigmented Lesionsmentioning

confidence: 99%

Intense Pulsed Light Therapy

Gu¹,

Liu²,

Liu³

2017

Photomedicine - Advances in Clinical Practice

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Intense pulsed light (IPL) is one of the most effective nonablative approaches to treat skin photoaging. The broad range of wavelengths (500-1200 nm) emitted from IPL devices effectively target both melanin and hemoglobin in the skin. Numerous trials show the effectiveness and compatibility of IPL devices in a variety of skin conditions, especially in cosmetic indications such as hypertrichosis and telangiectasias. Compared with the wide clinical use of IPL, the biochemical and molecular mechanism is not clear. Both in vivo and in vitro studies demonstrate that IPL could increase the production of extracellular matrix, promote the proliferation of fibroblasts, and increase the secretion of TGF-β and matrix metalloproteinases, which play important roles in the photorejuvenation effects of IPL. However, investigations regarding the detailed underlying mechanism are necessary.

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“…According to a professional assessment, fi ve patients exhibited good improvements, whereas one patient showed excellent improvement, whereby therapeutic effi cacy was correlated to the number of treatment sessions and anatomical sites. In another study, Li et al [26] reported on the effi cacy and safety of the same IPL device (fl uence, 13 -17 J/cm 2 ; 560-/590-nm fi lters and double pulse or 590-/615-/640-nm fi lters and triple pulse; pulse duration, 3 -4 ms; delay time, 25 -40 ms) in the treatment of melasma in 89 Chinese patients. Patients received a total of four IPL treatments at 3-week intervals.…”

Section: Pigmented Lesionsmentioning

confidence: 99%

Use of intense pulsed light sources in dermatology: Update 2012

Babilas

2012

Photonics &Amp; Lasers in Medicine

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Intense pulsed light sources (IPLs) consist of fl ash lamps with bandpass fi lters and emit incoherent polychromatic pulsed light of a high intensity and determined wavelength spectrum, fl uence, and pulse duration. The combination of prescribed wavelengths, fl uencies, pulse durations, and pulse intervals facilitates the treatment of a wide spectrum of skin conditions. Hereby, IPLs follow the basic principle of a more or less selective thermal damage of the target. This review discusses the current literature on IPLs with regard to the treatment of unwanted hair growth, vascular lesions, pigmented lesions, and as a light source for photodynamic therapy and skin rejuvenation. It also summarizes the physics of IPLs and provides guidance for the practical use of IPLs.Keywords: laser; dermatology; vascular lesions; pigmented lesions; hair removal; skin. ZusammenfassungHochenergetische Blitzlampen, auch "intense pulsed light sources (IPLs)", ( intense pulsed light [IPL]) emittieren hochenergetisches, inkoh ä rentes Licht, welches mit Filters ä tzen auf einen gew ü nschten Wellenl ä ngenbereich eingegrenzt werden kann. Die Energiedichte, die Intensit ä t und die Pulsdauer kann in Grenzen variiert werden. Somit k ö nnen hochenergetische Blitzlampen ein vergleichsweise breites Indikationsfeld erschlie ß en. Hierbei folgt die Technologie den Prinzipien einer eingeschr ä nkt selektiven Photothermolyse der entsprechenden Zielstruktur. In diesem Review soll ein Update der Literatur zu hochenergetischen Blitzlampen geliefert werden. Schwerpunkte sind hierbei die Behandlung unerw ü nschten Haarwuchses, vaskul ä rer L ä sionen, pigmentierter L ä sionen und der Einsatz als Lichtquelle zur photodynamischen Therapie und zur Photorejuvenation.Schl ü sselw ö rter: Laser; Dermatologie; Vaskul ä re L ä sionen; Pigmentierte L ä sionen; Haut.

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Efficacy and Safety of Intense Pulsed Light in Treatment of Melasma in Chinese Patients

Abstract: IPL treatment is a good option for patients with melasma. Adverse actions of IPL were minimal and acceptable.

Cited by 79 publications

References 20 publications

Intense pulsed light (IPL): A review

Intense pulsed light (IPL): A review

Intense Pulsed Light Therapy

Use of intense pulsed light sources in dermatology: Update 2012

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