Efficacy and Safety of Great Saphenous Vein Sclerotherapy Using Standardised Polidocanol Foam (ESAF): A Randomised Controlled Multicentre Clinical Trial

Abstract

Standardised 3% polidocanol foam is more efficient and equally safe compared to 3% liquid polidocanol for treatment of GSV. In comparison to other studies a relatively small volume was injected into relatively large veins.

Clinical effectiveness and cost-effectiveness of minimally invasive techniques to manage varicose veins: a systematic review and economic evaluation

“…39 121 reported more haematoma events in the LS group than in the FS group. Lurie et al 42 reported significantly fewer cases of haematoma in the RFA group than in the surgery group at each follow-up (3 days, 1 week and 3 weeks; p < 0.05 for all time points).…”

“…Only three trials [119][120][121] included LS as a comparator (with FS) (see Table 8). The principal common comparator was therefore surgery (i.e.…”

“…Twelve of the 34 included trials failed adequately to report methods of either randomisation or allocation concealment, or reported inadequate methods. [77][78][79][80]83,98,101,114,117,[120][121][122] Two further trials reported adequate randomisation but inadequate allocation concealment. 97,100 These studies, as reported, therefore had a high risk of selection bias.…”

“…FS and ligation). However, further relevant RCTs might have been included, such as Rabe et al, 121 Hinchcliffe et al, 83 Gale et al, 53 Goode et al 55 and Rasmussen et al 95 The recently published (2011) clinical practice guidelines of the Society for Vascular Surgery and American Venous Forum also recommend EVLA, RFA and FS as effective alternatives to stripping and other modalities, but cite only a small number of RCTs with short-term follow-up, and one or two of the reviews cited here. 26 None of the previously published reviews or analyses acknowledged the limitation presented by exclusively technical recurrence, rather than symptomatic technical recurrence as an outcome.…”

Applications of Polidocanol in Varicose Vein Treatment Assisted by Exposure to Nd:YAG Laser Radiation

“…There are many works providing good results about the use of POL foam sclerotherapy (Alos et al, 2006;Cabrera et al, 2000;Cavezzi and Frullini, 1999;Frullini, 2000;Gachet, 2001;Garcia-Mingo, 1999;Hsu and Weiss, 2003;Ouvry et al, 2008;Rabe et al, 2008;Redondo and Cabrera, 2005;Santos, 2008;Tessari, 2000). The ability to be agitated and foamed increases the potency of detergents from 2 to 4 times by mechanically displacing blood and thus maximizing surface area and time in contact with endothelium.…”