Efficacy and Safety of Gabapentin in Comparison to Solifenacin Succinate in Adult Overactive Bladder Treatment

Chua, Michael; See, Manuel; Esmeňa, Ednalyn B.; Balingit, Jaime C.; Morales, Marcelino L.

doi:10.1111/luts.12152

Cited by 20 publications

(9 citation statements)

References 26 publications

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“…In experimental fashion, inosine, resiniferatoxin, an E-series prostaglandin 1 receptor antagonist, kynurenine gene transfer via viruses, gamma-aminobutyric acid A and B receptor agonists muscimol and baclofen, a transient receptor potential 1 and a transient receptor potential vanilloid 1 receptor antagonists, an arginase inhibitor, a prostacyclin receptor antagonist, an endothelin-A receptor antagonist, and memantine have been shown to be beneficial [ 24 – 33 ]. Clinical studies have indicated that mirabegron, tetrahydrocannabinol-cannabidiol oral spray, anticholinergic preparations, and gabapentin are effective in the management of a neurogenic overactive detrusor [ 13 – 18 , 34 , 35 – 39 ]. However, there is still a group of patients who are unresponsive to the combination of an anticholinergic with the β-adrenergic therapeutic.…”

Section: Discussionmentioning

confidence: 99%

“…With the aim of providing an option to these patients, several molecules have been reported to be successful in an experimental fashion [ 12 ]. Among them, gabapentin, a sodium channel blocker, has also been found to be clinically beneficial in suppressing contractions of the detrusor with an acceptable side effect profile in both adults and children, as well as in neurogenic overactive bladder as in overactive bladder syndrome [ 13 – 18 ]. In this paper we report the results of a single neuro-urology working group that comprises 27 adult patients who did not respond to the combination of an anticholinergic and mirabegron and were treated with add-on gabapentin therapy.…”

Section: Introductionmentioning

confidence: 99%

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Gabapentin add-on therapy for patients with spinal cord injury associated neurogenic overactive detrusors that are unresponsive to combined anticholinergic and beta-3 adrenergic therapy

Cakici

Kaya

Sancı

et al. 2021

Cent european J Urol

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Introduction Spinal cord injury is a major cause of lifelong morbidity and functional micturition problems. Some patients are refractory to the available therapeutics, even when used in combination. In this paper we report our results of using gabapentin as an add-on treatment in refractory overactive detrusor cases secondary to spinal cord injury. Material and methods A total of 27 patients who had a spinal cord injury between the levels of the second thoracic and fourth lumbar vertebrae and had an overactive detrusor in urodynamic studies were included in this retrospective study. The patients were selected due to the fact that they also had not responded to a combination of an anticholinergic and mirabegron and had neuropathic pain. Gabapentin treatment was added to the previous therapy. Demographics, previous treatments, chronic conditions, urodynamic findings, clinical and urodynamic responses are reported in this paper. Results We observed a response to treatment in the urodynamic studies of 11 patients (40.17%), in terms of decreased detrusor contractions, maximal detrusor pressure, and the number of incontinence episodes. Sixteen patients did not respond to the gabapentin add-on therapy and were referred for Botulinum toxin injections to the bladder. Conclusions Gabapentin add-on therapy can be considered as a third or further option, before Botulinum toxin injection, for patients with neurogenic overactive detrusor who did not respond to the combination of anticholinergics and mirabegron. The approved usage of gabapentin for neurogenic pain justifies its usage in this area. In our selected patient group, who had not responded to the combination therapy, we observed a clinical benefit in one-third of the patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gabapentin add-on therapy for patients with spinal cord injury associated neurogenic overactive detrusors that are unresponsive to combined anticholinergic and beta-3 adrenergic therapy

Cakici

Kaya

Sancı

et al. 2021

Cent european J Urol

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“…Thirty-one RCTs [12][13][14][15][16][17][20][21][22][23][24][25][26][27][28][29][30][31][34][35][36][37][38][39][40][41][42][43][44][45][46] reported urgency episodes/d, containing a total of 13 treatment interventions and a total sample size of 23,764 cases (supplementary Figure 1). The results suggested that SOL5/10mg-QD was signi cantly more effective than other interventions, followed by SOL10mg-QD and SOL5mg-QD.…”

Section: Mean Daily Urgency Episodesmentioning

confidence: 99%

“…Fifty-ve RCTs [11,[13][14][15][17][18][19][20][21][22][23][24][25][26][27][28][30][31][32][33][34][35][36][37][38][40][41][42][43][44][45][46][47][48][49][50][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70] reported dry mouth, and to exclude nocebo effect on study outcomes, two articles [11,22]…”

Section: Safety Outcomesmentioning

confidence: 99%

Comparative Assessment of Efficacy and Safety of approved Oral Therapies for Overactive Bladder: A Systematic Review and Network Meta-analysis

Huang

Cui

et al. 2023

Preprint

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Purpose To compare the effectiveness and safety of marketed oral drugs for the treatment of overactive bladder. Methods Pubmed, Embase, Web of Science, and The Cochrane Register of Clinical Trials databases were systematically searched. The search time frame was from database creation to June 2, 2022, and randomized controlled double-blind trials of oral drugs for overactive bladder were screened. Trials were evaluated for quality using the Cochrane Risk of Bias Assessment Tool, and data were statistically analyzed using Stata 16.0 to compare and rank differences in effectiveness and safety. Result A total of 60 randomized controlled double-blind trials were included. Solifenacin 10mg was the most effective in micturitions and incontinence episodes, solifenacin 5/10mg in urgency and nocturia, fesoterodine 8mg in urgency incontinence and oxybutynin 5mg in voided volume/micturition. For safety, mirabegron, vibegron, solifenacin 5mg, extended-release tolterodine 4mg and extended-release oxybutynin 10mg all showed a better incidence of dry mouth; Compared to placebo, only imidafenacin 0.1mg, showed a significantly increased incidence in hypertension, solifenacin 10mg in urinary tract infection, fesoterodine 4/8mg and controlled release darifenacin 15mg in headache. Conclusion Solifenacin showed better efficacy. For safety, most anticholinergics were more likely to cause dry mouth and constipation, while β-adrenergic agonists showed an increased incidence of nasopharyngitis. The choice of therapeutic agent should be tailored to the patient's situation in order to find the best balance between efficacy and safety.

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“…10 Gabapentin may inhibit activity of the afferent C-fibers, and then prevent peripheral sensitization. 11 Gabapentin is also effective in neurogenic over-activity, because it can modulate irritability of the sacral reflex center. 12 The combined peripheral and central action of gabapentin may contribute to decrease in the occurrence of CRBD.…”

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confidence: 99%

Effect of preoperative gabapentin after transurethral prostate resection under general anesthesia

Wang

Liu

et al. 2020

SMJ

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Objectives: To investigate whether preoperative oral gabapentin could reduce postoperative pain, analgesic consumption and the occurrence of catheter-related bladder discomfort (CRBD). Methods: In this study, participants randomly received either 600 mg gabapentin or placebo orally 2 h prior to transurethral prostate resection. Visual analogue scale and Ramsay sedation scale was utilized to assess pain intensity and sedation status after surgery. Intravenous 1.5 mg.kg-1 tramadol was used for postoperative analgesia. Pain intensity, sedation status, CRBD, tramadol consumption, side effects and the overall satisfaction degree were assessed and recorded for 48 h after tracheal extubation. Original Article Results: Ninety participants given gabapentin and 91 participants given placebo completed the study. Lower visual analogue scale scores, less tramadol consumption, longer time to the first analgesic requirement, lower incidence of CRBD and nausea and higher satisfaction degree were detected in the patients receiving gabapentin compared with the patients receiving placebo. Conclusion: Preoperative oral gabapentin reduced postoperative visual analogue scale scores, tramadol consumption and the occurrence rate of CRBD and nausea, and consequently, increased the degree of patients' satisfaction after transurethral prostate resection.

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Efficacy and Safety of Gabapentin in Comparison to Solifenacin Succinate in Adult Overactive Bladder Treatment

Abstract: Gabapentin treatment with acceptable safety profile, improves OAB symptoms and HRQOL domains.

Cited by 20 publications

References 26 publications

Gabapentin add-on therapy for patients with spinal cord injury associated neurogenic overactive detrusors that are unresponsive to combined anticholinergic and beta-3 adrenergic therapy

Gabapentin add-on therapy for patients with spinal cord injury associated neurogenic overactive detrusors that are unresponsive to combined anticholinergic and beta-3 adrenergic therapy

Comparative Assessment of Efficacy and Safety of approved Oral Therapies for Overactive Bladder: A Systematic Review and Network Meta-analysis

Effect of preoperative gabapentin after transurethral prostate resection under general anesthesia

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