Efficacy and Safety of Ethanol Ablation for Thyroglossal Duct Cysts

Kim, S M; Baek, Jung Hwan; Kim, Y S; Sung, Jin Yong; Lim, Hyun Kyong; Choi, Hoon; Lee, Jeong Hyun

doi:10.3174/ajnr.a2296

Cited by 39 publications

(58 citation statements)

References 18 publications

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“…Therefore, EA may be the first-line treatment modality for cystic thyroid nodules, which has comparable therapeutic efficacy to, but is less expensive than, RF ablation. of the internal fluid was performed by using normal saline, which is known to be an effective method for treating viscous cystic nodules (1,4,23). Using these techniques, the volume reduction was excellent in both of our study patient groups, although the volume reduction of EA was still seen to be superior to that of RF ablation.…”

Section: Vascular and Interventional Radiology: Ethanol Versus Rf Ablmentioning

confidence: 91%

“…The secondary end points for the clinical outcomes included the binary therapeutic success rate, which was defined as the proportion of patients who showed a volume reduction of greater than 50% (1,15,23), improvement of symptoms and cosmetic problems, and the number of major complications. Major and minor complications were defined by the definitions of the Society of Interventional Radiology (25,26).…”

Section: Patientsmentioning

confidence: 99%

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Single-Session Treatment of Benign Cystic Thyroid Nodules with Ethanol versus Radiofrequency Ablation: A Prospective Randomized Study

Sung¹,

Baek²,

Kim³

et al. 2013

Radiology

166

165

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Purpose:To compare volume reduction of single-session ethanol ablation (EA) and radiofrequency (RF) ablation for cystic thyroid nodule treatment. Materials and Methods:All patients gave written informed consent to participate in this prospective institutional review board-approved study. From May 6, 2010, to August 8, 2011, in this singleinstitutional, noninferiority trial, 50 patients, each with a single cystic thyroid nodule, were randomly assigned to EA (25 patients; mean age for women, 45.7 years, and for men, 37.5 years) or RF ablation (25 patients; mean age for women, 45.1 years, and for men, 43.7 years) treatment.Internal fluid was aspirated prior to EA or RF ablation. Primary end point was the volume reduction ratio (percentage) at 6-month follow-up; the noninferiority margin was chosen as 28% (EA minus RF ablation). Secondary end points included therapeutic success rate, improvement of symptoms and cosmetic problems, and number of major complications. Analysis was performed primarily in intention-to-treat manner. A one-sided 95% confidence interval (CI) for the mean difference in volume reduction ratio 6 months after treatment was calculated to test for noninferiority. Subsequent superiority comparison of EA with RF ablation on a condition of establishment of the noninferiority of EA to RF ablation was preplanned and used two-sided 95% CI of the outcome difference. Results:The mean volume reduction was 96.9% in EA and 93.3% in RF ablation (n = 21 for each) (difference, 3.6%; lower bound of the one-sided 95% CI of the difference, 1.2%), thus demonstrating the noninferiority of EA to RF ablation. Two-sided 95% CI of the outcome difference was 0.7% to 6.5%, demonstrating significant superiority of EA to RF ablation. All patients demonstrated therapeutic success (P . .99). Mean symptom and cosmetic scores showed no significant difference in either group (P = .806 and P = .682, respectively). There were no major complications (P . .99). Conclusion:EA may be the first-line treatment modality for cystic thyroid nodules, which has comparable therapeutic efficacy to, but is less expensive than, RF ablation.q RSNA, 2013

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Section: Vascular and Interventional Radiology: Ethanol Versus Rf Ablmentioning

confidence: 91%

Section: Patientsmentioning

confidence: 99%

Single-Session Treatment of Benign Cystic Thyroid Nodules with Ethanol versus Radiofrequency Ablation: A Prospective Randomized Study

Sung¹,

Baek²,

Kim³

et al. 2013

Radiology

166

165

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“…After skin sterilisation and anaesthesia with 2% lidocaine at the puncture site, a 14-to 18-gauge needle was inserted into the nodule under ultrasound guidance via the trans-isthmic approach, thus preventing a change in the position of the needle tip and of ethanol leakage while swallowing [13,14,17,18,[21][22][23][24][25]. The maximum volume of internal fluid was aspirated, residual debris or colloid was removed by saline irrigation [20], and 99% ethanol was injected slowly into the cystic space. The volume of injected ethanol usually corresponded to about 50% of the volume of aspirated fluid.…”

Section: Methodsmentioning

confidence: 99%

“…At enrolment, patients were asked to rate their symptom score on a 10-cm visual analogue scale (0-10). Physicians recorded a cosmetic grade (1, no palpable mass; 2, a palpable mass but no cosmetic problem; 3, cosmetic problem on swallowing only; 4, readily detected cosmetic problem) [20][21][22][23].…”

Section: Patient Enrolmentmentioning

confidence: 99%

Cystic versus predominantly cystic thyroid nodules: efficacy of ethanol ablation and analysis of related factors

et al. 2012

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“…The 3 orthogonal diameters of each nodule (the largest diameter and the 2 diameters perpendicular to it) were measured, and the volume of each nodule was calculated by using the following equation: V ϭ abc / 6, where V is volume, a is the largest diameter, and b and c are the 2 perpendicular diameters. 8,13,24 Under US guidance, 1 of the 2 radiologists performed fine-needle aspiration on the solid component of each nodule. At enrollment, the patients were asked to rate their symptom score on a 10-cm Visual Analog Scale (0 -10).…”

Section: Preablation Assessmentmentioning

confidence: 99%

Combination Therapy Consisting of Ethanol and Radiofrequency Ablation for Predominantly Cystic Thyroid Nodules

Yoon

Baek

Lee

et al. 2013

AJNR Am J Neuroradiol

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SUMMARY:Predominantly cystic thyroid nodules are often aspirated before radiofrequency ablation to enhance its efficacy; however internal bleeding during the aspiration is a problem. We evaluated the feasibility and safety of ethanol ablation to control internal bleeding that occurred during preparatory aspiration. Between September 2010 and August 2011, 11 of 40 predominantly cystic nodules bled internally during fluid aspiration before radiofrequency ablation. To control the bleeding, 99% ethanol was injected. The efficacy of ethanol in controlling bleeding, final nodule volume and complications were assessed. Control of the bleeding by ethanol ablation and subsequent radiofrequency ablation was feasible in all patients. Ninety-one percent (10/11) could be treated in 1 session. The mean nodule volume dropped from 17.1 to 4.3 mL (P Ͻ .018). There were no major complications. Ethanol ablation and radiofrequency ablation combination therapy is a feasible and safe technique for treating predominantly cystic thyroid nodules that exhibit internal bleeding during preparatory aspiration. ABBREVIATIONS:EA ϭ ethanol ablation; RF ϭ radio-frequency; US ϭ ultrasound

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Efficacy and Safety of Ethanol Ablation for Thyroglossal Duct Cysts

Cited by 39 publications

References 18 publications

Single-Session Treatment of Benign Cystic Thyroid Nodules with Ethanol versus Radiofrequency Ablation: A Prospective Randomized Study

Single-Session Treatment of Benign Cystic Thyroid Nodules with Ethanol versus Radiofrequency Ablation: A Prospective Randomized Study

Cystic versus predominantly cystic thyroid nodules: efficacy of ethanol ablation and analysis of related factors

Combination Therapy Consisting of Ethanol and Radiofrequency Ablation for Predominantly Cystic Thyroid Nodules

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