Efficacy and safety of cyclosporine eyedrops in vernal keratoconjunctivitis

Pucci, Neri; Novembre, Elio; Cianferoni, Antonella; Lombardi, Enrico; Bernardini, Roberto; Caputo, Roberto; Campa, Luciana; Vierucci, A

doi:10.1016/s1081-1206(10)61958-8

Cited by 163 publications

(144 citation statements)

References 30 publications

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“…It also inhibits histamine release from mast cells and basophils and, through a reduction of IL-5 production, it may reduce the recruitment and the effects of eosinophils on the conjunctiva. [56][57][58][59] Moreover, the therapeutic efficacy of CsA in VKC, a conjunctival hyperproliferative disorder, seems to be related to the drug's efficacy in reducing conjunctival fibroblast proliferation rate and IL-1b production. 60 In a few patients with VKC, a systemic treatment may be required.…”

Section: Therapymentioning

confidence: 99%

Vernal keratoconjunctivitis

Bombardieri

Coassin

Aronni

et al. 2004

Eye

242

244

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Vernal keratoconjunctivitis (VKC) is an allergic eye disease that especially affects young boys. The most common symptoms are itching, photophobia, burning, and tearing. The most common signs are giant papillae, superficial keratitis, and conjunctival hyperaemia.Patients with VKC frequently have a family or medical history of atopic diseases, such as asthma, rhinitis, and eczema. However, VKC is not associated with a positive skin test or RAST in 42-47% of patients, confirming that it is not solely an IgE-mediated disease. On the basis of challenge studies as well as immunohistochemical and mediator studies, a Th2-driven mechanism with the involvement of mast cells, eosinophils, and lymphocytes has been suggested. Th2 lymphocytes are responsible for both hyperproduction of IgE (interleukin 4, IL-4) and for differentiation and activation of mast cells (IL-3) and eosinophils . Other studies have demonstrated the involvement of neural factors such as substance P and NGF in the pathogenesis of VKC, and the overexpression of oestrogen and progesterone receptors in the conjunctiva of VKC patients has introduced the possible involvement of sex hormones. Thus, the pathogenesis of VKC is probably multifactorial, with the interaction of the immune, nervous, and endocrine systems.The clinical management of VKC requires a swift diagnosis, correct therapy, and evaluation of the prognosis. The diagnosis is generally based on the signs and symptoms of the disease, but in difficult cases can be aided by conjunctival scraping, demonstrating the presence of infiltrating eosinophils. Therapeutic options are many, in most cases topical, and should be chosen on the basis of the severity of the disease. The most effective drugs, steroids, should however be carefully administered, and only for brief periods, to avoid secondary development of glaucoma.A 2% solution of cyclosporine in olive oil or in castor oil should be considered as an alternative. The long-term prognosis of patients is generally good; however 6% of patients develop corneal damage, cataract, or glaucoma.

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Section: Therapymentioning

confidence: 99%

Vernal keratoconjunctivitis

Bombardieri

Coassin

Aronni

et al. 2004

Eye

242

244

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“…Cyclosporine A (CsA) shows a selective effect against T-helper cells and prevents the synthesis and secretion of ILs. CsA has also been shown to block angiogenic factors induced by VEGF [11][12].Based on the above evidence and due to insufficient knowledge about the role of pre & postoperative use of topical Cyclosporine in cases of recurrent and vascularized pterygium, we studied the efficacy of topical Cyclosporine used pre & postoperatively on the recurrence of vascularized and recurrent pterygium post surgery.…”

Section: Introductionmentioning

confidence: 99%

Role of Pre And Postoperative Topical Cyclosporine (0.05%) on Recurrence in Recurrent And Vascularised Pterygium

Dhar¹,

Kapoor²,

Parihar³

2017

IOSR JDMS

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“…15 A significant improvement in the ocular signs by protecting eyes with caps and dark glasses has been reported. 16 Because the main function of the eyelashes is to protect the eyes 17 and, to our knowledge, no study has so far investigated the eyelash length in VKC patients, we evaluated the eyelash length in a large series of VKC children and in age-and gender-matched control subjects.…”

mentioning

confidence: 99%

Long Eyelashes in a Case Series of 93 Children With Vernal Keratoconjunctivitis

et al. 2005

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ABSTRACT. Objective. Vernal keratoconjunctivitis (VKC) is a chronic conjunctivitis that affects children mainly in temperate areas, with exacerbations in spring and summer. Eyelashes provide natural protection for the eyes from sunshine, wind, and foreign bodies. These factors induce a worsening of signs and symptoms in VKC, whereas mechanical protection of the eyes produces relief. The aim of this study was to evaluate eyelash length in a large series of VKC patients and in ageand gender-matched healthy subjects.Methods. Upper eyelash length was measured in 93 VKC patients (mean age: 8.7 years; range: 4 -18 years) with a digital caliper. History, clinical form, type of presentation, degree of severity, and drug therapy were evaluated. Skin tests and serum-specific immunoglobulin E for common allergens, serum-total immunoglobulin E, peripheral blood eosinophil counts, and serum eosinophil cationic protein were determined. Two age-and gender-matched control subjects for each VKC patient underwent the same eyelash measurement.Results. The upper eyelashes were significantly longer in VKC patients than in control subjects (mean ؎ SD: 8.9 ؎ 1.17 mm vs 7.9 ؎ 1.07 mm). In healthy subjects, a negative correlation was found between eyelash length and age. With multivariate analysis, unlike control subjects, the eyelash length in VKC patients did not correlate with age, was positively correlated with the degree of severity of VKC, and was negatively correlated with the use of topical cyclosporine.Conclusions. Patients with VKC had longer eyelashes than healthy matched subjects. ABBREVIATIONS. VKC, vernal keratoconjunctivitis; bFGF, basic fibroblast growth factor; s-P, substance P; IgE, immunoglobulin E; s-ECP, serum eosinophil cationic protein; PBEC, peripheral blood eosinophil count.

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Efficacy and safety of cyclosporine eyedrops in vernal keratoconjunctivitis

Cited by 163 publications

References 30 publications

Vernal keratoconjunctivitis

Vernal keratoconjunctivitis

Role of Pre And Postoperative Topical Cyclosporine (0.05%) on Recurrence in Recurrent And Vascularised Pterygium

Long Eyelashes in a Case Series of 93 Children With Vernal Keratoconjunctivitis

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