Role of Pre And Postoperative Topical Cyclosporine (0.05%) on Recurrence in Recurrent And Vascularised Pterygium

Dhar, Sanjay; Kapoor, Gaurav; Parihar, Jitendra Kumar Singh

doi:10.9790/0853-1601112325

Cited by 2 publications

(3 citation statements)

References 19 publications

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“…also showed no effect for CsA 0.05%, administered 4 weeks before and after surgery, on the recurrence rate (6% in the case and 8% in the control group). 19 However, the surgical technique (conjunctival limbal autograft with fibrin glue) and definition of the recurrence (any encroachment of conjunctiva >1 mm inside the limbus) were different in the study by Dhar from that in the present study, which could be another source of different rates reported. Other researchers reporting no effect for CsA have also used different inclusion criteria, such as bilateral pterygium with >2 mm corneal invasion.…”

Section: Discussioncontrasting

confidence: 71%

“… 16 However, the results of the studies are controversial in this regard, and some have suggested no significant effect for CsA on recurrence rate. 17 18 19 20 We aimed to evaluate the efficacy of 3-month administration of topical CsA 0.05% on postoperative recurrence after pterygium surgery. Accordingly, in the present study, we selected pterygium cases undergoing the rotational conjunctival autograft technique plus MMC and compared the efficacy of adjunctive therapy with CsA on the postoperative outcomes, including prevention of pterygium recurrence, inflammation, and complications compared with the control group.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of pterygium recurrence with and without using postsurgical topical cyclosporin a 0.05%: A randomized clinical trial

et al. 2022

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Purpose: To evaluate the efficacy of 3-month administration of topical cyclosporin A (CsA) 0.05% on postoperative recurrence after pterygium surgery. Methods: In this randomized clinical trial, 78 patients undergoing pterygium surgery (using the rotational conjunctival flap technique with mitomycin C [MMC]) were enrolled and randomly allocated into the control ( n = 39) and case (CsA) ( n = 39) groups in a single-blind method. The patients were examined on postoperative days 1, 3, and 7 and months 1, 3, and 6, and their best-corrected visual acuity, intraocular pressure, clinical inflammation, postoperative complications, and recurrence were compared. Results: The mean age of patients was 53.22 ± 9.99 years; most (57.7%) of them were men. The two groups were not different in terms of demographics, pterygium size, or pterygium grade. The clinical inflammation at the first and third postoperative months was not different between the groups ( P = 0.108 and 0.780, respectively). No serious complications were detected; complication rates were not different between the groups ( P = 0.99). The recurrence rate was 5.1% in the case group and 7.7%% in the control group ( P = 0.99). Conclusion: The present study showed no priority for 3-month administration of CsA 0.05% drops on postoperative outcomes, including prevention of pterygium recurrence, complications, and inflammation after the rotational conjunctival autograft technique with MMC.

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Section: Discussioncontrasting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Comparison of pterygium recurrence with and without using postsurgical topical cyclosporin a 0.05%: A randomized clinical trial

et al. 2022

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“…(3.4%), but lower than observed by Tok et al (12.9%) 17 . It may be higher than observed by Aydin et al because of the study population of only vascularized and recurrent pterygium, which is more prone for higher recurrence compared to primary pterygium 20 .…”

Section: Pak J Ophthalmolmentioning

confidence: 53%

Role of Topical Cyclosporine in Prevention of Pterygium Recurrence, after Primary Excision

Ahmed¹

2019

pak J Ophthalmol

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Purpose: To study the effect of cyclosporine on pterygium recurrence after primary excision Study Design: Non randomized controlled trial. Place and Duration of Study: The study was conducted in the department of Ophthalmology, Liaquat University of Medical and Health Sciences, Jamshoro from 2015 to 2017. Material and Methods: One hundred and thirty eyes of 65 patients having bilateral pterygium, at least 2 mm encroaching on the cornea, were selected for study. Dimensions of pterygium were measured on slit lamp. Half of the eyes were selected for post-operative cyclosporine and was named as cyclo- eye and fellow other eye was named as non-cyclo eye. Immediate post-operative treatment was tobramycin dexamethasone eye ointment twice and moxifloxacin eye drops three times daily until corneal epithelium was restored, followed by moxifloxacin and Cyclosporine eye drops twice daily until complete healing of ocular surface occurred and then cyclosporine 0.05% alone once daily in the evening up to three months. In the fellow eye tobramycin dexamethasone eye ointment and moxifloxacin eye drops were used for complete healing time followed by tears alone three times for three months. Follow up was done for six months. Results: Only Fifty-three patients who completed 6 months of follow-up were included in the results. In cyclo-eyes recurrent pterygium was observed only in 4 (07.55%) and in non-cyclo eyes recurrence was observed in 23 (43.40%) eyes. Mean healing time in cyclo-eyes was 21.1354 days and in non-cyclo-eyes, 15.0213 days. Conclusion: Cyclosporine is effective in reducing the recurrence rate of pterygium. Key Words: Pterygium, Cyclosporine, Cornea.

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Role of Pre And Postoperative Topical Cyclosporine (0.05%) on Recurrence in Recurrent And Vascularised Pterygium

Abstract: .

Cited by 2 publications

References 19 publications

Comparison of pterygium recurrence with and without using postsurgical topical cyclosporin a 0.05%: A randomized clinical trial

Comparison of pterygium recurrence with and without using postsurgical topical cyclosporin a 0.05%: A randomized clinical trial

Role of Topical Cyclosporine in Prevention of Pterygium Recurrence, after Primary Excision

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