Efficacy and safety of collagen implants for haemostasis of the vascular access site after coronary balloon angioplasty and coronary stent implantation

Arteriotomy Closure Devices for Cardiovascular Procedures

“…50 -52 The efficacy of the Vasoseal was subsequently confirmed in other randomized studies, 53,54 although other trials showed small increases in access-site complications or failed to demonstrate superiority over mechanical compression during PCI. 52,55,56 This device is no longer marketed because of findings from subsequent observational studies. Angio-Seal (St Jude Medical, St Paul, Minn) is among the most widely used ACDs.…”

Vascular complications associated with arteriotomy closure devices in patients undergoing percutaneous coronary procedures

“…Among the included publications, there were 18 randomized studies (2,339 and 2,197 patients) (3-11,13,24 -28,31-33) and 12 nonrandomized studies (10,257 and 22,273 patients) (12,(17)(18)(19)(20)(21)(22)(23)29,30,34,35). In 12 studies, the ACD compared with mechanical compression was Angio-Seal (3,6,9,11,12,(17)(18)(19)(20)(21)(22)(23); in 9 studies, VasoSeal (5,6,(25)(26)(27)(28)(29)(30); and in 15 studies, Perclose (7,8,10,12,13,18,19,21,23,(31)(32)(33)(34)(35). Six studies compared more than one device versus conventional compression techniques (12,…”

Remote suturing for percutaneous closure of popliteal artery access

“…The percutaneous application of collagen plugs is aimed at sealing the puncture tract either with an additional intravascular absorbable anchor (Angioseal, Gensey Nash, Exton, PA) [3,12] or without (Vasoseal, Datascope, Montvale, NJ) [2,13]. The use of collagen plugs reduced the time of compression but it did not prove to be superior compared to manual compression for achieving primary hemostasis, or significantly reducing vascular access site complications [1,12,14]. A feared complication of these devices is delayed postinterventional bleeding after resorption or dislodgment of the collagen plug [2,13].…”