2010
DOI: 10.1517/14656566.2010.526603
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Efficacy and safety of ciclesonide in patients with severe asthma: a 12-week, double-blind, randomized, parallel-group study with long-term (1-year) follow-up

Abstract: Ciclesonide 320 μg b.i.d. sustained lung function and asthma symptoms in patients with severe asthma over 12 weeks' treatment, and maintained lung function during a 40-week EP; ciclesonide 640 μg b.i.d. did not provide additional benefits. Long-term use of ciclesonide was not associated with increased local AEs or negative effects on cortisol levels.

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Cited by 9 publications
(9 citation statements)
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“…Among the all cases, (70%) had family history of asthma with 46.6% positive history of atopy. [6][7][8] Symptoms evaluated for, were wheezing, breathlessness, cough, sputum production, and nocturnal symptoms showed significant improvement at the end of 2 nd month and further improvement at the end of 6 th month. β 2 -agonist has been known to relax airway smooth muscle and enhance mucociliary clearance and decrease vascular permeability and modulate mediator release as well.…”
Section: Discussionmentioning
confidence: 98%
“…Among the all cases, (70%) had family history of asthma with 46.6% positive history of atopy. [6][7][8] Symptoms evaluated for, were wheezing, breathlessness, cough, sputum production, and nocturnal symptoms showed significant improvement at the end of 2 nd month and further improvement at the end of 6 th month. β 2 -agonist has been known to relax airway smooth muscle and enhance mucociliary clearance and decrease vascular permeability and modulate mediator release as well.…”
Section: Discussionmentioning
confidence: 98%
“…Evidence from a separate 12-week randomized, double-blind study suggests that ciclesonide 640 µg/day is close to the top of the dose-response curve, at least in terms of lung function and asthma symptom score [49]. Morning PEF increased significantly from baseline with both 320 µg b.i.d.…”
Section: Efficacy Of High-dose Ciclesonidementioning
confidence: 93%
“…and 640 µg b.i.d. in patients with severe asthma recorded no cases of patient-reported oral candidiasis [49]. A separate 24-week study comparing ciclesonide 320 µg b.i.d.…”
Section: Local Adverse Eventsmentioning
confidence: 97%
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