Background: Neuropathy, being a common complication of diabetes mellitus is frequently encountered in patients related to duration and severity of hyperglycaemia and had a multi-modality treatment approach by the treating physicians.Aims and Objective: To understand and analyze the current drug prescribing trends in the management of diabetic neuropathy in hospitalized and OPD patients in a tertiary care hospital.Materials and Methods: A cross sectional, observational study on (n=100) patients of either sex aged between 18 to 70 years admitted in the Department of Neuromedicine as well as visiting the OPD was conducted for a period of 3 months. Prescriptions were collected and the relevant information i.e. drugs prescribed for diabetic neuropathy only excluding other drugs mentioned in the prescription were documented in a predesigned, pretested proforma and were analyzed. Results: All the prescribed drugs i.e. (100%) were oral formulations. The average number of drugs prescribed per prescription for the treatment of diabetic neuropathy including indoor and OPD patients was 3.60 ± 0.66. Prescription of single drug for the treatment of diabetic neuropathy was found to be the commonest trend among the prescribers i.e. 78% of all the prescriptions and they were all in their generic form.Conclusion: Gabapentin and pregablin (antiepileptics), amitryptylline (anti-depressants) and methylcobalamine were most commonly prescribed drugs. Side effects profiles of these drugs were also well evident among the patients. Much larger multicentric studies of similar type including private and public hospitals might reflect the true scenario of current drug prescribing trend among physicians in treating diabetic neuropathy.Asian Journal of Medical Sciences Vol.9(5) 2018 8-11

Introduction: Pain during propofol injection is a very commonly and frequently encountered event during induction of anaesthesia. A 5HT3 antagonists like granisetron are commonly used just prior to intravenous propofol as pre anaesthetic medication to prevent emesis in patients.

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Objectives: to investigate whether behavior during hydroxyzine administration predicts children's behavior during dental treatment and whether behavior during treatment is affected by the complexity of treatment. Materials and method: 118 children aged 2 to 6.5 years old were treated under conscious sedation with oral premedication (3.7 mg/kg of hydroxyzine in a concentration of 50mg/5 cc. hydroxyzine) and 50% nitrous oxide/oxygen sedation. Children were divided in two age groups: aged 2 to ≤ 4 years old, and aged 4 ≯ to 6 years old. Behavior during first examination; cooperation during premedication administration, cooperation during nitrous oxide nose-mask placement, behavior during dental treatment, treatment duration and complexity of treatment were recorded. Results: More children in the older group took the premedication willingly (p=0.026). Significant correlation (p=0.002) between behavior during examination and nitrous oxide mask acceptance was found in the older age group. No correlation was found regarding the cooperation during premedication intake and behavior during treatment within and between age groups. No statistical differences within the groups and between the groups were found between complexity of treatment and behavior during treatment. Conclusions: Premedication intake is not a reliable predictive tool for behavior during treatment in children aged 2-6.5 years. Complexity of treatment does not influence behavior during treatment in children aged 2-6.5 years.

Introduction: Local anaesthetics are sometimes added with intrathecal adjuvants. Nalbuphine is a synthetic agonistantagonist of opioid μ receptor. Fentanyl is a highly potent lipophilic synthetic opioid with rapid onset of action and it acts like morphine. It can be used during spinal anaesthesia for the purpose of decreasing the postoperative pain. Aim: To compare the safety and efficacy of preservative free intrathecal nalbuphine and fentanyl as additives to intrathecal hyperbaric bupivacaine (0.5%) for spinal anaesthesia. Materials and Methods: A randomised double-blinded clinical study was undertaken at Calcutta National Medical College and Hospital, India during March 2020 to August 2021 in which a total of 100 patients, belonging to American Society of Anaesthesiology (ASA) I and II and undergoing elective lower abdominal surgery, were randomised into two equal group of 50 each. Group N received intrathecally 0.5 mg of nalbuphine with 3 mL (15 mg) of 0.5% hyperbaric bupivacaine, and Group F received 25 µg of Fentanyl with 3 mL (15 mg) of 0.5% hyperbaric. Visual Analogue Scale (VAS) score, Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Arterial Pressure (MAP) and Heart Rate (HR) were recorded at varied intervals during intraoperative and postoperative period. Results: Significantly lower (p<0.001) mean VAS scores was observed beyond six hour of postoperative period in the group F. No significant changes (p>0.05) in SBP, DBP, MAP and HR were there between the groups. Few adverse effects like (hypotension, bradycardia, nausea, vomiting) were observed more in the fentanyl group which was statistically insignificant (p>0.05). Conclusion: Intrathecal fentanyl as compared to nalbuphine produces a significant postoperative analgesia when administered as an adjuvant with hyperbaric bupivacaine in cases of lower abdominal surgery.