Efficacy and safety of bilastine 20 mg compared with cetirizine 10 mg and placebo in the treatment of perennial allergic rhinitis

Sastre, Joaquı́n; Mullol, Joaquim; Valero, Antonio; Valiente, Román

doi:10.1185/03007995.2011.640667

Cited by 62 publications

(101 citation statements)

References 15 publications

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“…The principle indications for the use of second generation H1 receptor antagonists are in the treatment of disease with inflammatory component like allergic rhinitis, conjunctivitis, idiopathic urticarial and diseases of allergic nature like hayfever 24 , pollinosis 25 , dermographism 26 and atopic eczema 27 . There are established facts that state that histamine play a role as a mediator of inflammation.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Activity of H1 Receptor Antagonist Cetirizine in Animal Models

S.H¹,

Santoshkumar²

2013

jemds

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AIM:The present study was designed to study anti-inflammatory activity of Cetirizine in albino rats and compare with standard drug Diclofenac. MATERIAL & METHODS: 1. Carrageenin induced rat paw edema method (Acute inflammation): 5 animals in each group (3groups) received orally 4% Gum acacia, Diclofenac sodium and Cetirizine respectively one hour before carrageenin injection into right paw. The rat paw edema was measured with plethysmograph after 3 hours and percentage inhibition of edema was calculated in each group. 2. Rexin pellet granuloma method (Chronic inflammation): Four rexin pellets were implanted into dorsum skin of each rat of 3 groups (n=5), which include control, Diclofenac and Cetirizine respectively. The animals were treated with fixed doses of drugs once a day for 7 days including the day of implantation of pellets and on 8th day rexin pellets were removed after sacrificing animals. Rexin pellets were kept in incubator at 60 0 C overnight. Pellets were then weighed and percent inhibition of granuloma tissue was calculated. 3. Study of Mast cell counts. RESULT: Cetirizine showed significant anti-inflammatory activity both in acute and chronic animal models. CONCLUSION: Cetirizine may be used as potential drug for both acute and chronic inflammation due to its anti-inflammatory property.

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Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Activity of H1 Receptor Antagonist Cetirizine in Animal Models

S.H¹,

Santoshkumar²

2013

jemds

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“…Необходимо отметить, что официально одобрен-ная доза биластина в соответствии с инструкцией по при-менению препарата Никсар ® составляет 20 мг/сут. Однако в большинстве случаев Никсар ® обладает хорошей пере-носимостью; в клинических исследованиях показано, что как в стандартной, так и в супратерапевтической дозе он имеет менее выраженный седативный потенциал, чем другие антигистаминные препараты второго поколения, не обладает кардиотоксическим эффектом [11][12][13].…”

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“…При этом, однако, наблюдался регион-зависимый эффект: пер-вичная эффективность была значительно выше для обоих видов лечения по сравнению с плацебо в Европе и Аргентине (P = 0,039). И, наоборот, в Южной Африке не наблюдалось значимых отличий эффективности в группах лечения по сравнению с контрольной группой, где пациен- [13,14]. Никсар ® обладает ограниченным потенциалом про-хождения через гематоэнцефалический барьер и, следо-вательно, очень малой степенью взаимодействия с Н 1 -рецепторами в ЦНС.…”

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New Original Antihistamine Bilastine in the Treatment of Allergic Rhinitis

Krivopalov¹,

Konoplev²,

Шервашидзе³

et al. 2017

Medicinskij sovet

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“…Several well-controlled trials have compared the efficacy of cetirizine with placebo and/or other H 1 antihistamines in adults and children with SAR and PAR/PER [43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80]. The majority of these trials have been conducted as double-blind, randomized, placebo-controlled, parallel-group studies in large groups of patients recruited from a single or multiple centres.…”

Section: Clinical Trials Of Cetirizine In Armentioning

confidence: 99%

The Clinical Use of Cetirizine in the Treatment of Allergic Rhinitis

2013

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Background: Cetirizine is among the first second-generation H₁ antihistamines (SGAHs) developed to provide selective H₁ receptor inhibition without central nervous system depression. Objective: The aim of this review is to summarize the amount of data collected over 25 years of clinical use of cetirizine and compare this with data available for other SGAHs in the management of patients with allergic rhinitis (AR). Methods: A comprehensive literature search for publications relating to cetirizine was performed using the Pubmed database, and relevant papers published in English were selected for detailed review. Results: Compared with the majority of other SGAHs, cetirizine was generally shown to have a more favourable pharmacological profile, to be well tolerated, be at least equally or more efficacious in attenuating/inhibiting nasal and ocular symptoms and to improve the quality of life in AR patients. The majority of clinical trials investigating the effect of SGAHs in AR patients further indicated that cetirizine was often employed as the main comparator active drug. Conclusion: Based on the evidence that cetirizine is a commonly employed active comparator drug in AR, it is tempting to suggest that cetirizine may be a suitable benchmark in the development of novel pharmacotherapies for AR.

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Efficacy and safety of bilastine 20 mg compared with cetirizine 10 mg and placebo in the treatment of perennial allergic rhinitis

Abstract: NCT01127620.

Cited by 62 publications

References 15 publications

Anti-Inflammatory Activity of H1 Receptor Antagonist Cetirizine in Animal Models

Anti-Inflammatory Activity of H1 Receptor Antagonist Cetirizine in Animal Models

New Original Antihistamine Bilastine in the Treatment of Allergic Rhinitis

The Clinical Use of Cetirizine in the Treatment of Allergic Rhinitis

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