Efficacy and safety of berberine in preventing recurrence of colorectal adenomas: A systematic review and meta-analysis

Fang, Shuangshuang; Guo, Song; Du, Shisuo; Cao, Zhen-Dong; Yang, Yang; Xiaolan, Su; Wei, Wei

doi:10.1016/j.jep.2021.114617

Cited by 18 publications

(29 citation statements)

References 26 publications

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“…Although berberine could contribute to some adverse events, such as constipation and nausea, these adverse effects are not serious. The most common event constipation disappeared once berberine was discontinued [ 136 , 137 ].…”

Section: Safety Of Berberinementioning

confidence: 99%

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Xiong

Huang

et al. 2022

Molecules

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Cancer has been a serious public health problem. Berberine is a famous natural compound from medicinal herbs and shows many bioactivities, such as antioxidant, anti-inflammatory, antidiabetic, anti-obesity, and antimicrobial activities. In addition, berberine shows anticancer effects on a variety of cancers, such as breast, lung, gastric, liver, colorectal, ovarian, cervical, and prostate cancers. The underlying mechanisms of action include inhibiting cancer cell proliferation, suppressing metastasis, inducing apoptosis, activating autophagy, regulating gut microbiota, and improving the effects of anticancer drugs. This paper summarizes effectiveness and mechanisms of berberine on different cancers and highlights the mechanisms of action. In addition, the nanotechnologies to improve bioavailability of berberine are included. Moreover, the side effects of berberine are also discussed. This paper is helpful for the prevention and treatment of cancers using berberine.

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Section: Safety Of Berberinementioning

confidence: 99%

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Xiong

Huang

et al. 2022

Molecules

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“…Subsequently, 105 studies were excluded after review of titles and abstracts. Consequently, 35 records were screened in full‐text, after which 11 studies were included in the final analysis (Asbaghi et al, 2020; Beba et al, 2019; Fang et al, 2022; Guo et al, 2021; Q. Hu et al, 2019; Lan et al, 2015; Y. Lu, Zhang, et al, 2022; Wei et al, 2016; Xie et al, 2019; Ye et al, 2021; L. S. Zhang et al, 2019). (Figure 1 presents the flow chart of the study selection).…”

Section: Resultsmentioning

confidence: 99%

Berberine and health outcomes: An umbrella review

Wang

et al. 2023

Phytotherapy Research

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Berberine is a plant extract widely used in clinical practice. This review aimed to summarize and to grade the available evidence on the association between berberine consumption and health-related outcomes. The PubMed, Cochrane Library, and Embase databases were searched for meta-analyses of randomized controlled trials (RCTs) assessing the efficacy and safety of berberine from inception to June 30, 2022. The AMSTAR-2 and GRADE system were used to assess the methodological quality and evidence level of the included meta-analyses. A total of 11 eligible meta-analyses were identified from 235 publications, which were published in peerreviewed journals between 2013 and 2022. The results revealed that berberine significantly affects blood glucose levels, insulin resistance, blood lipids, body parameters and composition, inflammatory markers, colorectal adenomas, and Helicobacter pylori infections as compared to controls. Common side effects of berberine consumption include gastrointestinal symptoms, such as constipation and diarrhea. Berberine is a safe medicinal plant ingredient that improves various clinical outcomes; however, there is a need for improvement of methodological quality in published meta-analyses. Additionally, the clinical effects of berberine need to be confirmed in high-quality RCTs.

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“…Several studies have reported the safety of berberine in the clinical treatment of various diseases. Berberine had more adverse events than placebo in preventing the recurrence of colorectal adenomas, but no serious adverse events were observed ( Fang et al, 2022 ). Berberine had good efficacy and safety in the treatment of type 2 DM, dyslipidemia, and hypertension ( Lan et al, 2015 ; Zhao et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

The exploration of anti-Vibrio parahaemolyticus substances from Phellodendri Chinensis Cortex as a preservative for shrimp storage

Zheng¹,

Liu²,

Cai³

et al. 2022

Front. Microbiol.

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This study aimed to optimize the ultrasonic-assisted extraction of the anti-Vibrio parahaemolyticus substances of Phellodendri Chinensis Cortex (ASPC), identify their active substances, and investigate their application in shrimp storage. The ultrasonic-assisted extraction conditions of ASPC were optimized through a single-factor experiment combined with response surface methodology. The optimal parameters were the ethanol concentration of 81%, the ultrasonic power of 500 W, the temperature of 80°C, the extraction time of 23 min, and the liquid/solid ratio 25 ml/g. The antibacterial zone diameter of the obtained extract determined by agar well diffusion method was 15.56 ± 0.22 mm, which was not significantly different from the predicted value (15.92 mm). Berberine was identified as one of the main chemical components of ASPC through high-performance liquid chromatography combined with standard control. The minimum inhibitory concentrations of ASPC and berberine determined by the tube dilution method were 0.25 and 0.03 mg/ml, respectively. The application of ASPC in shrimp storage showed that it could effectively inhibit the proliferation of V. parahaemolyticus on shrimps. This report offers good prospects for the use of Phellodendri Chinensis Cortex as a potential preservative against V. parahaemolyticus in aquatic products.

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Efficacy and safety of berberine in preventing recurrence of colorectal adenomas: A systematic review and meta-analysis

Cited by 18 publications

References 26 publications

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Berberine and health outcomes: An umbrella review

The exploration of anti-Vibrio parahaemolyticus substances from Phellodendri Chinensis Cortex as a preservative for shrimp storage

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