Efficacy and Safety of Acarbose in Insulin-Treated Patients With Type 2 Diabetes

Abstract

This study demonstrated that the addition of acarbose to patients with type 2 diabetes who are inadequately controlled with insulin and diet is safe and generally well tolerated and that it significantly lowers HbA1c and postprandial glucose levels.

A series of cinnamic acid derivatives and their inhibitory activity on intestinal α-glucosidase

“…Further in vivo experiments should be carried out in order to investigate the effect of the combination of these compounds and acarbose on lowering blood glucose in type 2 diabetes. In addition, the most common adverse effect of acarbose is a gastrointestinal disturbance induced by gas production upon fermentation of unabsorbed carbohydrates in the bowel 28 . Acarbose has rarely been associated with systemic adverse effects, but in some cases acute severe hepatotoxicity has been reported 29 .…”

α-Glucosidase inhibitory activity of cyanidin-3-galactoside and synergistic effect with acarbose

“…In order to investigate this effect, In vivo experiments should be further studied for the combination between cyanidin-3-galactoside and acarbose on lowering blood glucose in type 2 diabetes. In addition, the most common adverse effect of acarbose is a gastrointestinal disturbance, which is induced by producing gas with fermentation of the unabsorbed carbohydrates bowel [16][17][18]. Acarbose has rarely been associated with systemic adverse effect, but in some case acute severe hepatotoxicity has been reported [19][20][21].…”

Should Postprandial Glucose Be Measured and Treated to a Particular Target? Yes.

“…Other drugs such as ␣-glucosidase inhibitors also work by lowering PPG levels (30). Many of the existing sensitizers also have a positive effect on postprandial hyperglycemia, in addition to lowering fasting glucose (31).…”