Efficacy and Residual Effect Evaluation of a New Hypnotic, Triazolam

Veldkamp, W.; Straw, Robert N.; Metzler, Carl M.; Demissianos, H. V.

doi:10.1002/j.1552-4604.1974.tb02299.x

Cited by 44 publications

(12 citation statements)

References 4 publications

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“…The findings after administration of 0.5 mg triazolam are less consistent. Veldkamp et al (1974) reported no marked hangover effect. This finding has been questioned, however, by Chick (1980).…”

Section: Effects On Sleepmentioning

confidence: 94%

Midazolam and triazolam in out‐patients: a double‐blind comparison of hypnotic efficacy.

Silva¹,

Acioli²,

Naylor³

et al. 1983

Brit J Clinical Pharma

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I The hypnotic efficacy and the effect on the condition after morning awakening of midazolam 15 mg and of triazolam 0.5 mg were studied in a multicentre, double-blind cross-over study in 198 out-patients with sleeping difficulties of various origin. 2 The subjects received each drug for two consecutive nights, and completed a questionnaire each day on awakening. 3 Both midazolam and triazolam significantly shortened the sleep-onset latency, reduced the number of awakenings, and increased the total sleep time. 4 The state on awakening was also significantly improved after both compounds for several self-rated items. There was a difference only with regard to the patients' feeling of being under drug influence, which was reported as being significantly more marked after triazolam. 5 In conclusion, both compounds were effective and well tolerated in the doses used, only a few side-effects being reported.

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Section: Effects On Sleepmentioning

confidence: 94%

Midazolam and triazolam in out‐patients: a double‐blind comparison of hypnotic efficacy.

Silva¹,

Acioli²,

Naylor³

et al. 1983

Brit J Clinical Pharma

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“…Card sorting assessments are widely used and sensitive to a range of psychoactive drugs. Zimmermann-Tansella et al (1976) showed card sorting to be impaired following chlordesmethyldiazepam 10 and 20 mg and Tansella et al (1974) found similar impairment with N-desmethyldiazepam 20 mg. Malpas & Joyce (1969) Hindmarch (1975Hindmarch ( , 1976bHindmarch ( , 1979c Richter & Hobi (1976) Saario ( Korttila & Linnoila (1975);Mattila et al (1978) Hindmarch et al (1980) Seppala ( and Malpas (1972) found with nitrazepam 10 mg impaired card sorting time and Veldkamp et al (1974) found triazolam 0.5 and 1.0 mg adversely affected card sorting performance. Berry et al (1965) showed the sorting technique to be sensitive to changes in information processing brought about by three sub-anaesthetic doses of nitrous oxide and Haffner et al (1973) have shown coloured card sorting to be impaired by ethanol 1.22ml/kg and diazepam 10 and 20 mg.…”

Section: Gross Body Movementmentioning

confidence: 99%

“…Suzumura (1968) developed a kinetic visual acuity test which Roden, Harvey & Mitchard (1977) showed to be sensitive to the effects of alcohol alone and alcohol in combination with either nitrazepam or methaqualone and diphenhydramine (Mandrax). Veldkamp et al (1974) showed ocular convergence to be impaired by triazolam 0.5 and 1.0 mg and Aschoff et al (1975) found saccadic velocity reduced by diazepam 10 mg but not by sulpiride 100 mg. A study by Gendreau et al (1972) using the classical conditioning of the human eyelid response differentiated methamphetamine 20 mg from both placebo and diazepam 20 mg because of the observed improvement in discrimination produced by the psychostimulant. Gupta (1974) showed stimulant (dexamphetamine, 10 mg) and depressant (pheno-barbitone, 100 mg) drugs could be discriminated on the duration of the kinaesthetic figural after effect, while Malpas & Joyce (1969) found that nitrazepam 5 and 10 mg increased the latency and shortened the duration of visual after-images.…”

mentioning

confidence: 98%

Psychomotor function and psychoactive drugs.

Hindmarch¹

1980

Brit J Clinical Pharma

477

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“…The effective action of triazolam on sleep quality has generally been well studied (Veldkamp et al 1974;Vogel et al 1975;Kales et al 1976). These studies have shown that during undisturbed nights, the drug decreases slow Offprint requests to ."…”

mentioning

confidence: 99%

Effects of triazolam on heart rate level and on phasic cardiac response to noise during sleep

Libert¹,

Amoros²,

Muzet³

et al. 1988

Psychopharmacology

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The influence of triazolam on cardiac and respiratory activity of healthy male subjects was examined during nights disturbed by airplane noises and during undisturbed nights. Twenty-four subjects, divided into three groups of eight, slept in the laboratory for 7 nights (N0-N6). Following a double blind design, group A (control group) received a placebo every night. Group B received 0.25 mg triazolam and group C received 0.5 mg on nights N3, N4 and N5. On the other nights, they received a placebo. For all three groups, the nights N0, N3 and N5 were disturbed by 32 semi-randomly distributed airplane noises. Air and wall temperatures (20 degrees C) and air humidity (10 degrees C, 52%) were kept constant. Sleep measures, heart rate and respiratory rate were continuously recorded. Results showed that the largest dose of hypnotic drug produced an increase in tonic heart rate in the first part of each night throughout the treatment period (N3, N4, N5). When compared to baseline disturbed night N0, the phasic cardiac response to the noises was significantly attenuated on only the 1st treatment night (N3). Triazolam had no significant effect on nocturnal respiratory rate. No after-effects of the drug were observed for cardiac and respiratory activity on the withdrawal night (N6). The results suggest that, with regard to the drug action, there was either an increase in arousal threshold or a dissociation between long-lasting and short-lasting modifications of heart rate. Contrary to the single night attenuation of phasic cardiac responses, there was no drug tolerance for the hypnotic-related increase in tonic heart rate.

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Efficacy and Residual Effect Evaluation of a New Hypnotic, Triazolam

Cited by 44 publications

References 4 publications

Midazolam and triazolam in out‐patients: a double‐blind comparison of hypnotic efficacy.

Midazolam and triazolam in out‐patients: a double‐blind comparison of hypnotic efficacy.

Psychomotor function and psychoactive drugs.

Effects of triazolam on heart rate level and on phasic cardiac response to noise during sleep

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