Effet protecteur de l'h�mochromatose vis-�-vis des l�sions vasculaires s�niles ou diab�tiques

Pirart, J; Barbier, P

doi:10.1007/bf01211873

Cited by 10 publications

(2 citation statements)

References 50 publications

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“…Evidence supporting this concept is: 1) the high incidence of glucose intolerance or overt diabetes in I.H. [3,7]; 2) the decrease in insulin requirements in some patients following iron removal by phlebotomy [26]; 3) some special features unusual in idiopathic diabetes that is insulin-resistant [1,7] and less predisposition to development of macro-and microangiopathy [27,28].…”

Section: Normalmentioning

confidence: 99%

Glucagon secretion in diabetic patients with idiopathic haemochromatosis

et al. 1977

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The aim of the present investigation was to determine in patients with idiopathic haemochromatosis whether diabetes is of the primary type or secondary to pancreatic injury due to iron deposition. For this purpose, plasma glucagon concentrations were determined following arginine infusion or an oral glucose load in eight patients with diabetes and idiopathic haemochromatosis. The enhanced glucagon response to arginine and the nonsuppressibility of glucagon secretion by oral glucose found in these patients were similar to the results found in the same tests performed in our previous series of patients with "idiopathic" diabetes and at variance with those reported by others in patients with chronic pancreatitis.

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Section: Normalmentioning

confidence: 99%

Glucagon secretion in diabetic patients with idiopathic haemochromatosis

et al. 1977

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“…8 Until the 1970s, only rare examples of secondary diabetes associated with renal or retinal microangiopathy had been described. 9 " 18 Specifically, the presence of diabetic angiopathy was demonstrated 19 " 25 in 10 single cases of diabetic patients surviving total pancreatectomy for more than 10 yr. The rare occurrence of angiopathy has been explained by the fact that patients with secondary diabetes rarely live long enough to manifest microangiopathic complications.…”

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confidence: 99%

The Presence of Retinopathy in Patients with Secondary Diabetes Following Pancreatectomy or Chronic Pancreatitis

et al. 1983

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The incidence of diabetic retinopathy was evaluated by means of fluorescein angiography in 54 patients with diabetes secondary to chronic pancreatitis or to pancreatectomy. Thirty-one percent of the patients had background retinopathy; none had proliferative retinopathy. The percentage of patients with retinopathy was the same in groups with or without a family history of diabetes. There was no correlation between the degree of metabolic control, the levels of C-peptide, glucagon, growth hormone, and the presence of retinopathy. Retinopathy was correlated with the duration of diabetes. In conclusion, diabetes caused by pancreatitis or pancreatectomy has a significant prevalence of retinopathy, which has more benign characteristics and slower evolution than the retinopathy in patients with primary diabetes.

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Diabetes Secondary to Acquired Disease to the Pancreas

Prato¹,

Coppelli²,

Tiengo³

2004

International Textbook of Diabetes Mellitus

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Secondary diabetes is a condition of hyperglycemia which develops after the destruction of the pancreatic tissue by an acquired disease with subsequent impairment of exocrine and endocrine pancreatic functions. In general, any pathologic process of the pancreatic acinar tissue may results in an insult to its endocrine component, leading to some degree of hormone insufficiency. This condition was first described in 1788 by Sir Thomas Cawley, but it was soon appreciated that hyperglycemia can ensues acute and chronic pancreatitis, partial and total pancreatectomy, neoplasia as well as systemic processes involving the pancreas, such as hemochromatosis and cystic fibrosis. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus of the American Diabetes Association has identified these forms of diabetes as “diabetes secondary to diseases of the exocrine pancreas.” The new diagnostic criteria for diabetes introduced by the ADA and WHO Expert Committees are likely to influence the prevalence of diabetes in patients with diseases of the exocrine pancreas, but direct assessment using the new criteria is still too scanty. When the 1979 NDDG and 1985 WHO criteria are used, it can be calculated that diabetes secondary to disease of the exocrine pancreas represents, approximately, 0.5% of all cases of diabetes mellitus. Its frequency is likely to be twice as high in populations with heavy alcohol consumption. In the tropics, the prevalence of diabetes secondary to fibrocalculous pancreatitis can be as high as 10–20%. At variance with the selective B‐cell destruction occurring in type 1 diabetes, pancreatic diabetes is characterized by concomitant destruction of all endocrine cells of the islet of Langherans. The dual insulin–glucagon deficit is responsible for many of the metabolic and clinical manifestation of this form of diabetes, including lower risk for ketoacidosis and more frequent and severe hypoglycemic episodes. Since the late 1950s, the general idea has been that secondary diabetes was not associated with vascular complications. However, with the improved life expectancy of these patients during the past few years, a similar prevalence of retinopathy and microalbuminuria has been described in pancreatic and type 1 diabetes mellitus. The knowledge of the hormonal, metabolic, and clinical features of these forms of diabetes is essential in defining the most appropriate therapeutic strategies.

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Effet protecteur de l'h�mochromatose vis-�-vis des l�sions vasculaires s�niles ou diab�tiques

Abstract: Schutzeffekt der Hgimoehromatose gegeni~ber senilen und diabetischen Gefaflleiden Zusammemfassung. I. Spezifisehe und unspezifische 17"

Cited by 10 publications

References 50 publications

Glucagon secretion in diabetic patients with idiopathic haemochromatosis

Glucagon secretion in diabetic patients with idiopathic haemochromatosis

The Presence of Retinopathy in Patients with Secondary Diabetes Following Pancreatectomy or Chronic Pancreatitis

Diabetes Secondary to Acquired Disease to the Pancreas

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