Glucagon secretion in diabetic patients with idiopathic haemochromatosis

Passa, P; Luyckx, A; Carpentier, Jean‐Louis; Lefèbvre, Pierre; Canivet, J

doi:10.1007/bf01234505

Cited by 10 publications

(6 citation statements)

References 24 publications

(31 reference statements)

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“…The reason for this restriction remains unknown. The persistence of a normal or high glucagon secretion [32,33] in these patients is in agreement with our observation, but does not allow us to conclude, as previously [34], that the islets of Langerhans are normal in iron overloaded patients.…”

Section: Discussionsupporting

confidence: 90%

The haemochromatotic human pancreas: a quantitative immunohistochemical and ultrastructural study

et al. 1987

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Insulin, glucagon, somatostatin and pancreatic polypeptide cells were quantified after immunoperoxidase staining in sections of pancreases obtained from nine control subjects and seven diabetic patients with primary or secondary iron overload. One was normoglycaemic, two had glucose intolerance and four presented insulin-requiring diabetes. The whole pancreas was studied, taking into account the heterogeneous distribution of the endocrine cells. In the diabetic patients, the weight of the pancreas tended to be lower. Iron overload predominated in the exocrine tissue, whereas in islets iron concentration was quite variable from case to case. At the Haemalun-Eosine staining the histological appearance of the islets was normal, their shape and size being unchanged; amyloid deposits were absent, as were atrophic islets. Immunoperoxidase staining revealed a severe reduction in the number of immunoreactive B cells in the four diabetic patients. The mass of immunoreactive B cells was calculated from their volume density and from the weight of each lobe of the pancreas. It averaged 950 mg in control subjects, 1580 mg in the normoglycaemic patient, 1010 mg in patients with glucose intolerance and 180 mg in insulin-requiring diabetic patients. The electron microscopic examination, performed in four cases, revealed that the iron deposits were restricted to B cells and associated with progressive loss of their endocrine granules. The study shows that the pancreatic islet abnormalities in iron overloaded diabetic patients are completely different from those of Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic patients. This constitutes a further argument for a specific role of iron in the pathogeny of diabetes in haemochromatotic patients.

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Section: Discussionsupporting

confidence: 90%

The haemochromatotic human pancreas: a quantitative immunohistochemical and ultrastructural study

et al. 1987

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“…Although the results presented here confirm earlier findings (Gay et al, 1968;Passa et al, 1977) showing that in patients with idiopathic haemochromatosis and diabetes mellitus glucagon secretion is not diminished, they stress the importance of adsquate methods in the measurement of plasma glucagon. Using these, it becomes evident that this form of diabetes is not associated with raised plasma levels of glucagon (Fig.…”

Section: Discussionsupporting

confidence: 86%

“…On the other hand, cryptogenic diabetes mellitus is characteristically associated with raised plasma levels of glucagon Muller et al, 1970;Buchanan and McCarroll, 1972;Day and Anderson, 1973) and, by analogy, this would argue in favour of raised glucagon levels in patients with haemochromatosis and diabetes. The recent report by Passa et al (1977) Received for publication 2 October 1978 in eight patients with diabetes and haemochromatosis. In fact, these authors have reported increased levels of plasma glucagon as measured with the glucagon antiserum 30-K.…”

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confidence: 99%

Plasma glucagon in diabetes of haemochromatosis: too low or too high?

Müller¹,

Berger²,

Cüppers³

et al. 1979

Gut

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“…However, hepatic glucagon clearance could also be impaired in patients with severe parenchymal damage and portalsystemic shunting (15,17,18). Cirrhosis may contribute to the hyperglucagonemia found by us and others (28) in hemochromatotics, although in diabetic subjects the lack of the restraining influence of insulin on glucagon secretion would play a major role. In this regard, it is noteworthy that pancreatic b cells are more sensitive to the toxic effects of iron overload than a cells (29,30).…”

Section: Discussionmentioning

confidence: 83%

Pattern of Plasma Cyclic Nucleotides and Related Hormones in Liver Cirrhosis and Hepatocellular Cacinoma

Bamonti-Catena

Peracchi²,

Conte³

et al. 1998

CCLM

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To evaluate the pattern of plasma cyclic adenosine 3',5'-monophosphate, cyclic guanosine 3',5'-monophosphate, atrial natriuretic factor and glucagon levels in different stages of chronic liver diseases, we measured these variables in 20 normal subjects, 25 patients with genetic hemochromatosis, associated with liver cirrhosis in 19 cases and not in six, eight patients with compensated and 15 with decompensated alcoholic or posthepatitic cirrhosis, and 12 with hepatocellular carcinoma. All variables were within the normal range in non-cirrhotic hemochromatotic patients. Cyclic adenosine 3',5'-monophosphate levels were within the normal range (9.5-15.7 nmol/l) in hemochromatotic cirrhotics and elevated in other patients. Cyclic guanosine 3',5'-monophosphate, atrial natriuretic factor and glucagon were above the normal ranges (1.92-5.91 nmol/l, 8.8-62.7 ng/l, and 39-165 ng/l, respectively) in most patients with cirrhosis both with and without hemochromatosis and in most individuals with hepatocellular carcinoma. Cyclic guanosine 3',5'-monophosphate correlated with atrial natriuretic factor in the former groups but not in the latter. These findings indicate that glucagon and atrial natriuretic factor hypersecretion is an early event in cirrhosis, regardless of its etiology. In hepatocellular carcinoma, the underlying cirrhosis may account for most hormonal and metabolic changes although cyclic guanosine 3',5'-monophosphate increases could also be due to the neoplastic process per se.

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Glucagon secretion in diabetic patients with idiopathic haemochromatosis

Cited by 10 publications

References 24 publications

The haemochromatotic human pancreas: a quantitative immunohistochemical and ultrastructural study

The haemochromatotic human pancreas: a quantitative immunohistochemical and ultrastructural study

Plasma glucagon in diabetes of haemochromatosis: too low or too high?

Pattern of Plasma Cyclic Nucleotides and Related Hormones in Liver Cirrhosis and Hepatocellular Cacinoma

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