Efferent projections of the parabigeminal nucleus in rats: A horseradish peroxidase (HRP) study

Watanabe, Kazuo; Kawana, Etsuro

doi:10.1016/0006-8993(79)90123-9

Cited by 110 publications

(30 citation statements)

References 9 publications

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“…Dense cell labeling was also observed in the contralateral parabigeminal nucleus. This result probably should be ascribed to FluoroGold uptake by fibers running in the supraoptic decussation (106).…”

Section: Retrograde Labeling From the Mepdmentioning

confidence: 87%

Obesity-inducing amygdala lesions: examination of anterograde degeneration and retrograde transport

King

Cook

Rossiter

et al. 2003

American Journal of Physiology-Regulatory, Integrative and Comp

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King, Bruce M., Jack T. Cook, Kirk N. Rossiter, and Bethany L. Rollins. Obesity-inducing amygdala lesions: examination of anterograde degeneration and retrograde transport. Am J Physiol Regul Integr Comp Physiol 284: R965-R982, 2003. First published November 14, 2002 10.1152/ajpregu.00249.2002.-Small lesions centered in the posterodorsal region of the medial amygdala resulted in excessive weight gains in female rats. Unilateral lesions were nearly as effective as bilateral lesions in the first 48 h after surgery (ϩ21 to ϩ32 g). Assessment of lesion damage was done by both qualitative evaluation and by a quantitative grid-point counting method. The critical sites for weight gain were the intra-amygdaloid bed nucleus of the stria terminalis and the posterodorsal medial amygdaloid nucleus. Incidental damage to the overlying globus pallidus was negatively related to weight gain. The cupric silver method for demonstrating axonal degeneration was applied to brains with obesity-inducing lesions. A dense pattern of degenerating terminals was found in the lateral septum, amygdala, ventral striatum, and ventromedial hypothalamus. Degeneration in the paraventricular nucleus of the hypothalamus was scarce or absent. Small retrograde tracer injections made in either the intra-amygdaloid bed nucleus of the stria terminalis or in the posterodorsal medial amygdaloid nucleus labeled cells in the amygdala, lateral septum, and hypothalamus, reciprocating the anterograde projections from the amygdala to these areas. The data suggest that subdivisions of the posterodorsal amygdala participate in the regulation of feeding in a manner that is similar to the better-known role of this part of the brain in mediating reproductive behavior. Although topographical differences may exist within the amygdaloid and hypothalamic subdivisions regulating these two sexually dimorphic behaviors, the relays engaged by feeding-related connections and those related to reproduction are remarkably parallel. nucleus accumbens; hypothalamus; stria terminalis SEVERAL RECENT STUDIES have demonstrated that bilateral electrolytic lesions of the amygdala in female rats can result in marked hyperphagia and excessive weight gains. Daily food intake nearly doubles, and weight gains of 20-30 g during the first 3 days after lesions are not unusual (e.g., 45, 50-53, 84). Weight gains of Ն100 g in 20-25 days have been observed (50, 51). The lesions result in a marked preference for carbohydrates (53). Although food intake eventually returns to normal, the excessive weight gain is maintained indefinitely, with a marked increase in adipose tissue (50).These results are similar to those reported many years ago for cats, dogs, and primates (including humans) given amygdaloid lesions or temporal lobectomies (e.g., 9, 32, 37, 70, 103). In the rat, the effective lesion site for hyperphagia and obesity has recently been identified as the posterodorsal part of the medial amygdaloid nucleus (MePD) and the intra-amygdaloid bed nucleus of the stria terminalis (BSTIA), together ...

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Section: Retrograde Labeling From the Mepdmentioning

confidence: 87%

Obesity-inducing amygdala lesions: examination of anterograde degeneration and retrograde transport

King

Cook

Rossiter

et al. 2003

American Journal of Physiology-Regulatory, Integrative and Comp

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“…As in birds, reptiles, amphibian, and teleosts, most neurons in the nucleus parabigeminalis are cholinergic (Mufson et al, 1986;Hall et al, 1989;Jeon et al, 1993). Although the nucleus parabigeminalis appears to be a uniform structure in cats and ferrets (Graybiel, 1978;Baleydier and Magnin, 1979;Edwards et al, 1979;Sherk, 1978Sherk, , 1979aRoldá n et al, 1983;Jiang et al, 1996), it is divided into two or three cytoarchitectonically distinct subdivisions in the squirrel and rat (Tokunaga and Otani, 1978;Watanabe and Kawana, 1979;Linden and Perry, 1983;Wang and Karten, unpubl. obs.).…”

Section: Identical Nuclei and Pathways In The Mammalian Brainmentioning

confidence: 94%

Columnar projections from the cholinergic nucleus isthmi to the optic tectum in chicks (Gallus gallus): A possible substrate for synchronizing tectal channels

et al. 2005

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The cholinergic division of the avian nucleus isthmi, the homolog of the mammalian nucleus parabigeminalis, is composed of the pars parvocellularis (Ipc) and pars semilunaris (SLu). Ipc and SLu were studied with in vivo and in vitro tracing and intracellular filling methods. 1) Both nuclei have reciprocal homotopic connections with the ipsilateral optic tectum. The SLu connection is more diffuse than that of Ipc. 2) Tectal inputs to Ipc and SLu are Brn3a-immunoreactive neurons in the inner sublayer of layer 10. Tectal neurons projecting on Ipc possess "shepherd's crook" axons and radial dendritic fields in layers 2-13. 3) Neurons in the mid-portion of Ipc possess a columnar spiny dendritic field. SLu neurons have a large, nonoriented spiny dendritic field. 4) Ipc terminals form a cylindrical brush-like arborization (35-50 microm wide) in layers 2-10, with extremely dense boutons in layers 3-6, and a diffuse arborization in layers 11-13. SLu neurons terminate in a wider column (120-180 microm wide) lacking the dust-like boutonal features of Ipc and extend in layers 4c-13 with dense arborizations in layers 4c, 6, and 9-13. 5) Ipc and SLu contain specialized fast potassium ion channels. We propose that dense arborizations of Ipc axons may be directed to the distal dendritic bottlebrushes of motion detecting tectal ganglion cells (TGCs). They may provide synchronous activation of a group of adjacent bottlebrushes of different TGCs of the same type via their intralaminar processes, and cross channel activation of different types of TGCs within the same column of visual space.

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“…After 1-3 days, each rat was deeply anesthetized and per fused with saline and then with the fixative consisting of 1.25% glutaraldehyde, 0.5% paraformaldehyde and 5% saccharose in 0.1 M phosphate buffer (pH 7.4). The brain was removed and stored in 30% saccharose and 1.25% glutaraldehyde at 4°C for 24 h [1Vatanabe and Kawana, 1979]. This procedure decreases the inac tivation of the enzyme by reducing the paraformal dehyde concentration [Kim and Strick, 1976].…”

Section: Methodsmentioning

confidence: 99%

A horseradish peroxidase study on the mammillothalamic tract in the rat

Watanabe

Kawana²

1980

Cells Tissues Organs

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The mammillary projections to the anterior thalamic nuclei were investigated in the rat, using the horseradish peroxidase (HRP) method. Pars centralis of the medial mammillary nucleus projects to the medial portion of the anteromedial nucleus (AM). Pars medialis (Mm) of the medial mammillary nucleus sends fibers to the ipsilateral AM and sparsely to the medial portion of the contralateral side. The ventral and dorsal portions of Mm project to the anterior and posterior portions of AM, respectively. The pars lateralis (Ml) and pars posterior (Mp) of the medial mammillary nucleus send fibers predominantly to the ipsilateral anteroventral nucleus and sparsely to the contralateral side. A slight difference between Ml and Mp projections was observed. The lateral mammillary nucleus projects bilaterally to the anterodorsal nucleus.

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Efferent projections of the parabigeminal nucleus in rats: A horseradish peroxidase (HRP) study

Cited by 110 publications

References 9 publications

Obesity-inducing amygdala lesions: examination of anterograde degeneration and retrograde transport

Obesity-inducing amygdala lesions: examination of anterograde degeneration and retrograde transport

Columnar projections from the cholinergic nucleus isthmi to the optic tectum in chicks (Gallus gallus): A possible substrate for synchronizing tectal channels

A horseradish peroxidase study on the mammillothalamic tract in the rat

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