A horseradish peroxidase study on the mammillothalamic tract in the rat

Watanabe, Kazuo; Kawana, Etsuro

doi:10.1159/000145322

Cited by 41 publications

(19 citation statements)

References 24 publications

(36 reference statements)

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“…Moreover, Met immunoreactivity is present in the anteroventral, but not the anterodorsal subnuclei of the anterior thalamus (Fig. 11E,F), consistent with the selective patterns of innervation within this nucleus by the medial mammillary nuclei (Guillery, 1957; Cruce, 1975; Watanabe and Kawana, 1980; Seki and Zyo, 1984). The medial mammillary nuclei themselves receive prominent input from subicular projection neurons at the septal pole of the hippocampus (Swanson and Cowan, 1977; Allen and Hopkins, 1989; Gonzalo-Ruiz et al, 1992).…”

Section: Resultssupporting

confidence: 75%

Dynamic gene and protein expression patterns of the autism‐associated met receptor tyrosine kinase in the developing mouse forebrain

Judson

Bergman

Campbell

et al. 2009

J of Comparative Neurology

165

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The establishment of appropriate neural circuitry depends upon the coordination of multiple developmental events across space and time. These events include proliferation, migration, differentiation, and survival - all of which can be mediated by hepatocyte growth factor (HGF) signaling through the Met receptor tyrosine kinase. We previously found a functional promoter variant of the MET gene to be associated with autism spectrum disorder, suggesting that forebrain circuits governing social and emotional function may be especially vulnerable to developmental disruptions in HGF/Met signaling. However, little is known about the spatiotemporal distribution of Met expression in the forebrain during the development of such circuits. To advance our understanding of the neurodevelopmental influences of Met activation, we employed complementary Western blotting, in situ hybridization and immunohistochemistry to comprehensively map Met transcript and protein expression throughout perinatal and postnatal development of the mouse forebrain. Our studies reveal complex and dynamic spatiotemporal patterns of expression during this period. Spatially, Met transcript is localized primarily to specific populations of projection neurons within the neocortex and in structures of the limbic system, including the amygdala, hippocampus and septum. Met protein appears to be principally located in axon tracts. Temporally, peak expression of transcript and protein occurs during the second postnatal week. This period is characterized by extensive neurite outgrowth and synaptogenesis, supporting a role for the receptor in these processes. Collectively, these data suggest that Met signaling may be necessary for the appropriate wiring of forebrain circuits with particular relevance to social and emotional dimensions of behavior.

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Section: Resultssupporting

confidence: 75%

Dynamic gene and protein expression patterns of the autism‐associated met receptor tyrosine kinase in the developing mouse forebrain

Judson

Bergman

Campbell

et al. 2009

J of Comparative Neurology

165

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“…Anteromedial nucleus receives projections from: medial mammillary bodies (Watanabe and Kawana, 1980; Seki and Zyo, 1984)rostral dorsal reticular nucleus (Shibata, 1992)prelimbic and medial orbital cortices (Shibata and Naito, 2005)anterior cingulate and dysgranular retrosplenial cortex (Shibata, 1993b; Shibata and Naito, 2005; Wright et al, 2010)secondary motor cortices (Shibata and Naito, 2005)entorhinal cortex (Wright et al, 2010)subiculum (Wright et al, 2010) …”

Section: Connectivity To Other Structuresmentioning

confidence: 99%

“…Anterodorsal nucleus receives projections from: lateral mammillary bodies (Watanabe and Kawana, 1980; Shibata, 1992)subiculum, para-and postsubiculum (Seki and Zyo, 1984; Van Groen and Wyss, 1990a,c; Wright et al, 2010)retina (Conrad and Stumpf, 1975; Itaya et al, 1981, 1986)anterior cingulate cortex (Shibata and Naito, 2005)granular retrosplenial cortex (Wright et al, 2010)caudal dorsal reticular nucleus (Shibata, 1992) …”

Section: Connectivity To Other Structuresmentioning

confidence: 99%

“…Anteroventral nucleus receives projections from: medial mammillary bodies (Watanabe and Kawana, 1980)caudal dorsal reticular nucleus and laterodorsal tegmental nucleus (Shibata, 1992)subiculum and postsubiculum (Van Groen and Wyss, 1990c; Wright et al, 2010)anterior cingulate cortex, granular and dysgranular retrosplenial cortex (Van Groen and Wyss, 1990b, 2003; Shibata and Naito, 2005; Wright et al, 2010)secondary motor cortex (Shibata and Naito, 2005) …”

Section: Connectivity To Other Structuresmentioning

confidence: 99%

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The anterior thalamus provides a subcortical circuit supporting memory and spatial navigation

Jankowski¹,

Rönnqvist²,

Tsanov³

et al. 2013

Front. Syst. Neurosci.

274

190

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The anterior thalamic nuclei (ATN), a central component of Papez' circuit, are generally assumed to be key constituents of the neural circuits responsible for certain categories of learning and memory. Supporting evidence for this contention is that damage to either of two brain regions, the medial temporal lobe and the medial diencephalon, is most consistently associated with anterograde amnesia. Within these respective regions, the hippocampal formation and the ATN (anteromedial, anteroventral, and anterodorsal) are the particular structures of interest. The extensive direct and indirect hippocampal-anterior thalamic interconnections and the presence of theta-modulated cells in both sites further support the hypothesis that these structures constitute a neuronal network crucial for memory and cognition. The major tool in understanding how the brain processes information is the analysis of neuronal output at each hierarchical level along the pathway of signal propagation coupled with neuroanatomical studies. Here, we discuss the electrophysiological properties of cells in the ATN with an emphasis on their role in spatial navigation. In addition, we describe neuroanatomical and functional relationships between the ATN and hippocampal formation.

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“…The AVN receives dense inputs from the medial mammillary nucleus (Seki and Zyo, 1984;Watanabe and Kawana, 1980), which contains cells that respond to AHV or fire in a linear relationship with running speed. Further, these cells are strongly modulated by theta rhythmicity (Sharp and Turner-Williams, 2005).…”

Section: The Importance Of the Hd Signalmentioning

confidence: 99%