Efferent fiber connections of the dorsal and deep tegmental nuclei of gudden. An experimental study in the cat

Briggs, Terrence L.; Kaelber, William W.

doi:10.1016/0006-8993(71)90414-8

Cited by 90 publications

(8 citation statements)

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“…In order to understand how the mammillary bodies might contribute to memory, it is necessary to determine their anatomical connections. In nonprimate brains it has long been appreciated that the mammillary bodies receive two major sets of afferents – one from the subiculum (hippocampal formation) and the other from Gudden's tegmental nuclei (Valenstein and Nauta, 1959; Briggs and Kaelber, 1971; Meibach and Siegel, 1975; Swanson and Cowan, 1977; Hyakawa and Zyo, 1984; Allen and Hopkins, 1989). Although it has been established that there are dense subicular projections to the mammillary bodies in monkeys (Poletti and Cresswell, 1977; Rosene and Van Hoesen, 1977; Aggleton et al, 2005), it remains to be demonstrated whether the primate mammillary bodies also receive direct projections from Gudden's tegmental nuclei.…”

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confidence: 99%

Projections from Gudden's tegmental nuclei to the mammillary body region in the cynomolgus monkey (Macaca fascicularis)

Saunders¹,

Vann²,

Aggleton³

2012

J of Comparative Neurology

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Gudden's tegmental nuclei provide major inputs to the rodent mammillary bodies, where they are thought to be important for learning and navigation. Comparable projections have yet to be described in the primate brain, where part of the problem has been in effectively delineating these nuclei. Immunohistochemical staining of tissue from a series of macaque monkeys (Macaca mulatta) showed that cells in the region of both the ventral and dorsal tegmental nuclei selectively stain for parvalbumin, thus helping to reveal these nuclei. These same tegmental nuclei were not selectively revealed when tissue was stained for SMI32, acetylcholinesterase, calbindin, or calretinin. In a parallel study, horseradish peroxidase was injected into the mammillary bodies of five cynomolgus monkeys (Macaca fascicularis). Retrogradely labeled neurons were consistently found in the three subdivisions of the ventral tegmental nucleus of Gudden, which are located immediately below, within, and above the medial longitudinal fasciculus. Further projections to the mammillary body region arose from cells in the anterior tegmental nucleus, which appears to be a rostral continuation of the infrafascicular part of the ventral tegmental nucleus. In the dorsal tegmental nucleus of Gudden, labeled cells were most evident when the tracer injection was more laterally placed in the mammillary bodies, consistent with a projection to the lateral mammillary nucleus. The present study not only demonstrates that the primate mammillary bodies receive parallel inputs from the dorsal and ventral tegmental nuclei of Gudden, but also helps to confirm the extent of these poorly distinguished nuclei in the monkey brain.

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confidence: 99%

Projections from Gudden's tegmental nuclei to the mammillary body region in the cynomolgus monkey (Macaca fascicularis)

Saunders¹,

Vann²,

Aggleton³

2012

J of Comparative Neurology

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“…Axon terminals coming from the LM also contain mainly round vesicles with asymmetric synaptic contacts in the dorsal tegmental nucleus. The medial mammillary nucleus receives ascending afferents from the superior central nucleus (Bobillier et al 1975;Vertes and Martin 1988) and the ventral tegmental nucleus (Briggs and Kaelber 1971;Shibata 1987). Axon terminals from these nuclei are exclusively terminals containing pleomorphic vesicles (Allen and Hopkins 1989;Hayakawa and Zyo 1991), and they contact mainly the intermediate and proximal dendrites as well as neuronal somata.…”

Section: Discussionmentioning

confidence: 99%

“…~ ' Anterograde and retrograde tracing studies have shown that the TDV sends many fibers to the LM (Briggs and Kaelber 1971;Hayakawa and Zyo 1984;Shibata 1987), and a few fibers to the lateral hypothalamic nucleus (Berk and Finkelstein 1981; 1985) and the contralateral dorsal tegmental nucleus (Liu et al 1984). The TDV receives fibers from the LM, the lateral habenular nucleus, the interpeduncular nucleus, the prepositus hypoglossi nucleus, and the supragenual nucleus (Herkenham and Nauta 1979;Hayakawa et al 1981;Liu et al 1984;Shibata and Suzuki 1984;Hayakawa and Zyo 1985).…”

Section: Discussionmentioning

confidence: 99%

“…The lateral mammillary nucleus (LM) receives many fibers from the subicular complex (Meibach and Siegel Offprint requests to: T. Hayakawa 1977; Swanson and Cowan 1977) and the pars ventralis of the dorsal tegmental nucleus of Gudden (TDV) (Morest 1961;Briggs and Kaelber 1971; 1973; Hayakawa and Zyo 1984), while sending collateral fibers to the pars dorsalis and ventralis of the dorsal tegmental nucleus of Gudden, the medial pontine nucleus, the nucleus reticularis tegmenti pontis, and the bilateral anterodorsal thalamic nuclei (Niimi et al 1972;Cruce 1977;Hayakawa and Zyo 1982, 1989Veazey etal. 1982b).…”

Section: Introductionmentioning

confidence: 99%

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Ultrastructural study of ascending projections to the lateral mammillary nucleus of the rat

Hayakawa

Zyo

1992

Anat Embryol

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We examined the synaptic organization of ascending projections from the pars ventralis of the dorsal tegmental nucleus of Gudden (TDV) and the laterodorsal tegmental nucleus to the lateral mammillary nucleus (LM). The LM neuropil consists of terminals containing pleomorphic synaptic vesicles and forming symmetric synaptic contact, and terminals containing round synaptic vesicles and forming asymmetric synaptic contact. They make up 63% and 37%, respectively, of all axodendritic terminals. All axosomatic terminals contain pleomorphic vesicles and make symmetric contact. Following injection of WGA-HRP into the TDV, many anterogradely labeled terminals and retrogradely labeled cells are found in the LM. Labeled terminals contact mainly proximal (more than 2 microns diameter) and intermediate (1-2 microns diameter) dendrites. Serial ultrathin sections of the LM show that 55% of axosomatic terminals are labeled anterogradely. Following injection of WGA-HRP into the laterodorsal tegmental nucleus, many anterogradely labeled terminals are found in the LM, but no retrogradely labeled cells are present. Labeled terminals contact mainly distal (less than 1 micron diameter) and intermediate dendrites as well as somata. In the LM neurons, 46% of axosomatic terminals are labeled anterogradely. All labeled terminals from these nuclei contain pleomorphic vesicles and make symmetric synaptic contact. These results indicate that almost all axosomatic terminals come from the TDV and the laterodorsal tegmental nucleus, which send inhibitory inputs to the lateral mammillary nucleus.

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“…That is, most of the degeneration produced by lesions of predatory attack sites in either the lateral hypothalamus [Cut and F lynn, 1971a, b] or the ventral tegmental area of the midbrain [Chi et al, 1976] followed the course of the ipsilateral ascending and descend ing medial forebrain bundle; and small unilateral lesions made at attack sites in the ventral tegmental area of the midbrain eliminated the attack evoked by stimulation of lateral hypothalamic attack sites ipsilateral, but not contralateral to the lesions [Proshansky and Bandler, 1975;Proshansky et al, 1974], In addition, significant contributions to the ascend ing medial forebrain bundle, originating in or passing through the ventro medial periaqueductal gray region from which attack was elicited, have been demonstrated with experimental neuroanatomic methods [Briggs and Kaelber, 1971;Hamilton, 1973a, b;Morest, 1961;Nauta and Haymaker, 1969] and a component of the descending medial forebrain bundle which projects to and through this ventral periaqueductal gray re gion has also been reported [Guillery, 1957;Nauta. 1958;Nauta and Haymaker, 1969].…”

Section: Regional Stimulation: Behavioral and Anatom Ic Correlatesmentioning

confidence: 99%

Predatory Behavior in the Cat Elicited by Lower Brain Stem and Hypothalamic Stimulation: a Comparison

Bandler¹

1977

Brain Behav Evol

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The predatory attack of a cat against a rat elicited by lateral hypothalamic, ventral midbrain and ventromedial periaqueductal gray stimulation has been compared. Regardless of the region stimulated, the attack behaviors were found to be identical with respect to response topography, preference for the rat as an attack object, the distance at which the cats would approach and attack a rat and the success in finding and attacking the rat when the cats were blindfolded. However, the minimum current required to elicit the predatory attack by periaqueductal gray stimulation was 3–4 times less than that required to elicit the same behavior by ventral midbrain and lateral hypothalamic stimulation. The difficulty in reconciling these results with the preeminent role assigned to the hypothalamus in the organization of predatory aggressive behavior was considered.

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Efferent fiber connections of the dorsal and deep tegmental nuclei of gudden. An experimental study in the cat

Cited by 90 publications

References 10 publications

Projections from Gudden's tegmental nuclei to the mammillary body region in the cynomolgus monkey (Macaca fascicularis)

Projections from Gudden's tegmental nuclei to the mammillary body region in the cynomolgus monkey (Macaca fascicularis)

Ultrastructural study of ascending projections to the lateral mammillary nucleus of the rat

Predatory Behavior in the Cat Elicited by Lower Brain Stem and Hypothalamic Stimulation: a Comparison

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