Effekte eines mit Brain-Derived Neurotrophic Factor funktionalisierten pastenartigen Knochenzements auf die metaphysäre Heilung in einem neuen murinen osteoporotischen Frakturmodell

Kauschke, Vivien; Schneider, Marius; Jauch, Annika; Schumacher, May-Britt; Kampschulte, Marian; Rohnke, Marcus; Henß, Anja; Bamberg, Coralie; Trinkaus, Katja; Gelinsky, M; Heiss, Christine Antonie; Lips, KS

doi:10.1055/s-0039-1680049

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“…Addition of BDNF to bioactive glass/α-TCP composites showed an anti-inflammatory effect, as interpreted from a significantly reduced number of circulating leukocytes, in the osteoporotic muscarinic acetylcholine receptor M3 knockout mouse model. However, an equivalent effect was not observed in Wildtype mice [69].…”

Section: Incorporation Of Cells Growth Factors and Other Biologicalmentioning

confidence: 85%

In Vivo Behavior of Bioactive Glass-Based Hybrids in Animal Models For Bone Regeneration

Shal¹

2020

Preprint

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This review presents the recent advances and the current state-of-the-art of bioactive glass-based hybrid biomaterials for bone regeneration. Hybrid materials comprise two (or more) constituents at the nanometre scale, in which typically, one constituent is organic and functions as the matrix phase and the other constituent is inorganic and behaves as the filler phase. Such materials, thereby, more closely resemble natural bio-nanocomposites such as bone. Various glass compositions in combination with a wide range of natural and synthetic polymers have been evaluated in vivo under experimental conditions ranging from unloaded critical-sized defects to mechanically-loaded, weight-bearing sites with highly favourable outcomes. Additional possibilities include controlled release of anti-osteoporotic drugs, ions, antibiotics, pro-angiogenic substances and pro-osteogenic substances. Histological and morphological evaluations suggest the formation of new, highly vascularised bone that displays signs of remodelling over time. With the possibility to tailor the mechanical and chemical properties through careful selection of individual components, as well as the overall geometry (from mesoporous particles and micro-/nanospheres to 3D scaffolds and coatings) through innovative manufacturing processes, such biomaterials present exciting new avenues for bone repair and regeneration.

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Section: Incorporation Of Cells Growth Factors and Other Biologicalmentioning

confidence: 85%

In Vivo Behavior of Bioactive Glass-Based Hybrids in Animal Models For Bone Regeneration

Shal¹

2020

Preprint

View full text Add to dashboard Cite

show abstract

Effekte eines mit Brain-Derived Neurotrophic Factor funktionalisierten pastenartigen Knochenzements auf die metaphysäre Heilung in einem neuen murinen osteoporotischen Frakturmodell

Cited by 1 publication

References 0 publications

In Vivo Behavior of Bioactive Glass-Based Hybrids in Animal Models For Bone Regeneration

In Vivo Behavior of Bioactive Glass-Based Hybrids in Animal Models For Bone Regeneration

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