Effects produced by Royal Jelly on haematopoiesis: relation with host resistance against Ehrlich ascites tumour challenge

Bincoletto, Cláudia; Eberlin, Samara; Figueiredo, Camila A.; Luengo, Marcos B.; Queiroz, Mary L.S.

doi:10.1016/j.intimp.2004.11.015

Cited by 86 publications

(63 citation statements)

References 54 publications

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“…To our knowledge, the antiinflammatory and antioxidant actions of RJ have ap- International Journal of Hematology and Oncology peared in the literature to date. [16][17][18][19][20][21] In our study, the absence of any difference between the control group and the groups using only RJ50 and RJ100 alone groups demonstrates that RJ did not cause oxidative stress individually and did not involve a direct change in antioxidant enzyme activity. Its antioxidant effects mentioned above further confirm this result.…”

Section: Discussionmentioning

confidence: 85%

“…One of the important physiological functions of RJ is its antioxidative action because it has the ability to help prevent various chronic diseases, such as cancer and cardiovascular disease caused by the attack of free radicals. [15][16][17][18][19][20][21] Recent reports suggest that RJ offers protection against oxidative, stress-induced biological dysfunction. Therefore, it is possible that RJ may offer some protection against radiation side effects.…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Royal Jelly Against Radiation-Induced Acute Oral Mucositis.

Cihan¹

2014

UHOD

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The purpose of this study was to investigate the effects of royal jelly against radiation-induced oral mucositis in rats. This study was comprised of 48 adult male Sprague-Dawley rats, each between eight and 12 weeks old and weighing 275±35 g. These were divided randomly into six groups; Group C (control), Group IR (irradiation), Group IR+RJ50 (irradiation plus 50 mg/kg royal jelly), Group IR+RJ100 (irradiation plus 100 mg/kg royal jelly), Group RJ50 (50 mg/kg royal jelly), and Group RJ100 (100 mg/kg royal jelly). The degree of mucositis, the animal's body mass, and food intake were evaluated. Biochemical and histopathological methods were utilized for the evaluation of mucositis, and a hemogram, oxidative stress markers, and biochemical parameters were analyzed. Tongue samples were also processed for histopathological examination. Irradiation significantly increased oral mucositis, decreased the thrombocyte and neutrophil counts, and resulted in a reduction of food intake accompanied by weight loss. In addition, a significant increase in malondialdehyde (MDA) levels and decreased superoxide dismutase (SOD) and catalase (CAT) activities were found (p< 0.001). Irradiation plus 50 mg/kg royal jelly caused normalization in the quantitative, biochemical, and histopathological parameters compared with the group that underwent irradiation alone.Irradiation plus 100 mg/kg royal jelly did not provide superior radioprotection against radiation-induced toxicities. Royal jelly was administered orally to reduce oral mucositis as it may be more suitably applied. International Journal of Hematology and Oncology INTRODUCTION Radiotherapy (RT) is an essential therapeutic modality in the management of head and neck cancers. Despite advances in RT technology, oral mucositis has not been ameliorated in head and neck cancer patients treated with radiotherapy. The current head and neck radiotherapy protocols have a mucositis incidence of 85-100%. The severity of mucositis depends on many variables, such as anti-cancer treatment protocol, age, diagnosis of the patient, level of oral hygiene during therapy, and genetic factors.

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

The Effects of Royal Jelly Against Radiation-Induced Acute Oral Mucositis.

Cihan¹

2014

UHOD

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“…É importante reforçar que muitos tumores experimentais produzem mudanças marcantes na resposta hematopoiética medular e extramedular dos animais, causando anemia, depleção tímica, imunossupressão e leucocitose dependente de granulócitos (Bincoletto et al, 2005) confirmadas pelas observações desta pesquisa.…”

Section: Resultsunclassified

Efeito do miriadenolídeo isolado de Alomia myriadenia (Asteraceae) sobre o tumor de Erlich ascítico no camundongo

Junior¹,

Souza-Fagundes

Cassali³

et al. 2006

Arq. Bras. Med. Vet. Zootec.

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Efeito do miriadenolídeo isolado de RESUMOEstudou-se atividade antineoplásica de um produto natural isolado de Alomia myriadenia (miriadenolídeo) no modelo do tumor de Ehrlich em camundongos. Dezoito fêmeas de camundongo Swiss foram inoculadas com 2x10 7 células viáveis de tumor de Ehrlich via intraperitoneal (0,3ml) e posteriormente distribuídas aleatoriamente em três grupos que receberam: grupo I (controle) -0,3ml de solução de Hanks; grupo II31µg/kg de miriadenolídeo; e grupo III -139µg/kg de miriadenolídeo. No oitavo dia de experimento, foram realizados exames hematológicos e perfil protéico sérico eletroforético. Coletou-se todo o líquido ascítico para avaliação do volume, aparência, pH, contagem de células viáveis e inviáveis, realização de esfregaços para contagem de células claras e escuras, leucócitos e avaliação das regiões organizadoras de nucléolos argentafins (AgNORs). Foram realizados exames macro e microscópicos do baço, fígado e rins e aspirado o conteúdo da medula óssea dos fêmures direito e esquerdo de cada animal para avaliação da relação mielóide:eritróide. Não houve diferença significativa no volume, pH, contagem de células viáveis e inviáveis entre os três grupos estudados, observando-se valores de 17,6 x 10 4 células tumorais viáveis no grupo III, 27,7 x 10 4 no grupo II e 21,1 x 10 4 no grupo I. As AgNORs apresentaram-se pequenas, com distribuição difusa e incontáveis no grupo I, e em menor quantidade no grupo III. Os animais do grupo III apresentaram a menor concentração protéica total sérica (4,7g/dl) (P<0,05) quando comparados com os do grupo II (5,3g/dl) e do grupo I (5,1g/dl). Os valores de albumina foram semelhantes nos três grupos (2,6g/dl), e as globulinas totais foram maiores (P<0,05) no grupo II (2,71g/dl) quando comparadas com os valores médios do grupo III (2,11g/dl) e semelhantes ao grupo I (2,43g/dl). Não houve diferença entre alfa e beta globulinas entre os três grupos estudados, porém as gamaglobulinas foram maiores (P<0,05) no grupo II (1,72g/dl) quando comparadas com as do grupo III (1,13g/dl). Com relação ao eritrograma e leucograma, não houve diferença significativa entre os grupos tratados. A relação mielóide:eritróide foi maior (P<0,05) no grupo III (1,40) quando comparada com a relação nos grupos I (0,92) e II (0,61). A contagem de reticulócitos também foi maior (P<0,05) (11,2) no grupo III, quando comparada com as dos grupos I (4,3) e II (3,6). Em todos os grupos, observou-se degeneração hepática. II (3.6). In all groups, hepatic degeneration was observed.

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“…Previous studies have reported antitumoral effects of RJ on various types of tumor, including Ehrlich ascetic tumor (22), Sarcoma-180 ascites (23), and fibrosarcoma transplantable tumors (24). For the majority of tumors, RJ significantly prolongs the average life span of murine tumor models and the effect depends on the treatment protocol used (22,23).…”

Section: Discussionmentioning

confidence: 99%

“…For each of the three groups receiving RJ treatment, the daily doses of RJ were 0.5, 1.0 and 1.5 g/kg, respectively. RJ solution was prepared by dissolving RJ in distilled water (22). The weight of the mice and tumor sizes were measured periodically.…”

Section: Methodsmentioning

confidence: 99%

The effect of royal jelly on the growth of breast cancer in mice

et al. 2017

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Abstract. Due to various pharmacological properties, including antioxidative, anti-inflammatory and antibiotic properties, royal jelly (RJ) has been widely consumed in daily diets in numerous countries. In the present study, the effect of RJ on 4T1-bearing mice was investigated. The study was performed by feeding 4T1-bearing mice with RJ using either the prophylactic-therapeutic (PTRJ) or therapeutic (TRJ) method. The experimental results for the PTRJ group demonstrated that the weight of tumor was significantly reduced (RJ 0.5 and 1.5 g/kg); and in the serum, the levels of interleukin (IL)-2 (RJ 0.5 and 1.5 g/kg), interferon (IFN)-α, superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) were significantly elevated, but the concentrations of IL-4 (RJ 0.5 and 1.5 g/kg) and IL-10 (RJ 1.0 g/kg) were significantly decreased. In addition, the activities of T-AOC and glutathione reductase (GR) were significantly improved in the liver, whereas in the kidney, the activities of T-AOC and GR were significantly increased only under the dose of 0.5 g/kg. For the TRJ group, the antitumor effect of RJ was not significant; the change in IL-2, IFN-α, SOD and T-AOC levels in the serum, and the change in T-AOC and GR in liver were similar to those observed in the PTRJ groups. RJ treatment was demonstrated to reduce the development of breast tumor in mice, and simultaneously improve the antioxidant capacity of the serum, liver and kidney, particularly using the prophylactic-therapeutic method. These results corroborated the efficacy of RJ supplementation in diets. The results of the present study suggest that the antioxidant and immunomodulatory activities of RJ serve an important role on antitumor growth.

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Effects produced by Royal Jelly on haematopoiesis: relation with host resistance against Ehrlich ascites tumour challenge

Cited by 86 publications

References 54 publications

The Effects of Royal Jelly Against Radiation-Induced Acute Oral Mucositis.

The Effects of Royal Jelly Against Radiation-Induced Acute Oral Mucositis.

Efeito do miriadenolídeo isolado de Alomia myriadenia (Asteraceae) sobre o tumor de Erlich ascítico no camundongo

The effect of royal jelly on the growth of breast cancer in mice

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