Effects on wound healing of tricalcium phosphate‐collagen complex implants in periodontal osseous defects in the dog

Sugaya, Akira; Minabe, Masato; Hori, Tomohide; Tatsumi, Junichi; Watanabe, Yukio; Ikeda, Katsumi; Numabe, Yukihiro; Hayashi, Hideaki; Kamoi, Kazumi

doi:10.1111/j.1600-0765.1990.tb01207.x

Cited by 19 publications

(7 citation statements)

References 14 publications

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“…Compounding with polymers such as collagen is one of a measure to overcome this poor mouldability [102]. Collagen composites with HA [103][104][105][106] or -TCP [107][108][109][110] have been developed and recently studied for such large defects. OCP combined with collagen has also been fabricated and shown to have not only moldability but also to retain intrinsic osteoconductivity of OCP [102].…”

Section: Resultsmentioning

confidence: 99%

Bone Regeneration by Synthetic Octacalcium Phosphate and its Role in Biological Mineralization

Сузукі¹,

Imaizumi²,

Kamakura³

et al. 2008

CMC

100

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Octacalcium phosphate (Ca8H2(PO4)6 * 5H2O; OCP) has been advocated to be a precursor of biological apatite crystals in bone and tooth. Recent studies, using physical techniques, showed that OCP is present as a transient phase during biological apatite formation in human dentin, porcine enamel and murine bone. However, there is still a controversy regarding the chemical nature of the first mineral formed in the biominerals. A number of studies have demonstrated that synthetic OCP shows bone regenerative and biodegradable characteristics, rather than other calcium phosphate bone substitute materials, such as hydroxyapatite (Ca10(PO4)6(OH)2; HA) ceramic. It seems likely that synthetic OCP may be an alternative to autogenous bone graft. It is known that OCP contains alternative layers of water molecules and an apatite structure, and that the transition of OCP to HA is likely to be spontaneous and irreversible. The conversion process induces modification of local environment adjacent to OCP surface, including the changes in adsorption of serum proteins and concentration of calcium and inorganic phosphate ions. This article reviews the possible application to bone regeneration by synthetic OCP and the mechanism to enhance bone regeneration in relation to biological mineralization in bone and tooth.

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Section: Resultsmentioning

confidence: 99%

Bone Regeneration by Synthetic Octacalcium Phosphate and its Role in Biological Mineralization

Сузукі¹,

Imaizumi²,

Kamakura³

et al. 2008

CMC

100

View full text Add to dashboard Cite

show abstract

“…New periodontal fibers anchored in neoformed bone and cementum have been described by Nery et al 3 and De Lange,4 but not by Stahl and Froum5 or Sugaya et al. 6 In any event, the connective tissue appearing between the tooth and the new bone formation prevents ankylosis and subsequent radicular résorption. 7 Clinical use of HA is currently with an associated guided tissue regeneration (GTR) technique,8-9 involving the selection of periodontal ligament fibroblasts, a heterogeneous population specifically implicated in bone, liga- ment, and cementum regeneration processes.10 The specific effects of HA on periodontal ligament fibroblasts, in the early stages of periodontal repair, appear to be extremely important for the success of periodontal regeneration.…”

mentioning

confidence: 95%

Effects of Hydroxyapatite Particles on Periodontal Ligament Fibroblast‐Like Cell Behavior

Alliot‐Licht¹,

Lange

Grégoire

1997

Journal of Periodontology

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Although hydroxyapatite (HA), a synthetic calcium phosphate, is used in restoring bone defects associated with periodontal diseases, its specific effect on the periodontal ligament fibroblast population during the regeneration process is unclear. To determine the cellular events occurring in the presence of HA, human periodontal ligament fibroblasts (HPLF) were isolated and maintained in culture. The specificity of the cells was evidenced by their morphology, deposition of extracellular matrix components, and alkaline Phosphatase (ALP) activity (as a marker of osteoblastic differentiation of HPLF). Phase‐contrast investigations revealed morphological alterations of cells in contact with HA particles. Transmission electron microscopy demonstrated the phagocytotic process of HPLF toward HA particles. Moreover, the presence of HA particles was significantly related to an increase in the protein synthesis activity and a decrease in the proliferation and ALP‐specific activity of HPLF. These results provide new information on the phenotypic expression of HPLF, which is comparable to that of osteoblastic cells. A subpopulation of HPLF may be influenced by the presence of HA to undergo transient dedifferentiation prior to redifferentiating into osteoblasts. This process may be important as a means by which HA acts as an osteoconductive material. This experimental study improves our understanding of the cellular processes which occur during healing and regeneration of periodontal defects after implantation of biomaterials. J Periodontol 1997;68:158–165.

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“…Collagen has been reported to accelerate the regeneration and osteoconduction of cementum when used as a coating material with calcium phosphate ceramics and tricalcium phosphate [15]. Miyamoto et al fabricated AC containing atelocollagen and examined the basic properties of AC with atelocollagen content from 0.5% to 5%.…”

Section: Discussionmentioning

confidence: 99%

Effects of Apatite Cement Containing Atelocollagen on Attachment to and Proliferation and Differentiation of MC3T3-E1 Osteoblastic Cells

et al. 2016

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To improve the osteoconductivity of apatite cement (AC) for reconstruction of bone defects after oral maxillofacial surgery, we previously fabricated AC containing atelocollagen (AC(ate)). In the present study, we examined the initial attachment, proliferation and differentiation of mouse osteoblastic cells (MC3T3-E1 cells) on the surface of conventional AC (c-AC), AC(ate) and a plastic cell dish. The number of osteoblastic cells showing initial attachment to AC(ate) was greater than those attached to c-AC and similar to the number attached to the plastic cell wells. We also found that osteoblastic cells were well spread and increased their number on AC(ate) in comparison with c-AC and the wells without specimens, while the amount of procollagen type I carboxy-terminal peptide (PIPC) produced in osteoblastic cells after three days on AC(ate) was greater as compared to the others. There was no significant difference in regard to alkaline phosphatase (ALP) activity and osteocalcin production by osteoblastic cells among the three surface types after three and six days. However, after 12 days, ALP activity and the produced osteocalcin were greater with AC(ate). In conclusion, AC(ate) may be a useful material with high osteoconductivity for reconstruction of bone defects after oral maxillofacial surgery.

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Effects on wound healing of tricalcium phosphate‐collagen complex implants in periodontal osseous defects in the dog

Cited by 19 publications

References 14 publications

Bone Regeneration by Synthetic Octacalcium Phosphate and its Role in Biological Mineralization

Bone Regeneration by Synthetic Octacalcium Phosphate and its Role in Biological Mineralization

Effects of Hydroxyapatite Particles on Periodontal Ligament Fibroblast‐Like Cell Behavior

Effects of Apatite Cement Containing Atelocollagen on Attachment to and Proliferation and Differentiation of MC3T3-E1 Osteoblastic Cells

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