Effects on post-prandial glucose and AGE precursors from two initial insulin strategies in patients with Type 2 diabetes uncontrolled by oral agents

Sakharova, Olga V.; Lleva, Ranee R.; Dziura, James; Spollett, Geralyn R.; Howell, Scott K.; Beisswenger, Paul J.; Inzucchi, Silvio E.

doi:10.1016/j.jdiacomp.2012.03.027

Cited by 8 publications

(10 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 61 ] Numerous reports from RCTs and observational studies, albeit fewer than recovered for BIAsp, demonstrate the efficacy and safety of LM 25 and LM 50 in T2D in Eastern and Western patient populations. [ 62 63 64 65 66 67 68 69 70 71 ] The following provides a brief review of findings for insulin-treated and insulin-naive patients.…”

Section: B Iphasic I Nsulin L mentioning

confidence: 99%

“…In studies comparing LM 25 or LM 50 with glargine, greater HbA1c reductions were reported, and PPG control was significantly improved with premixed insulin. [ 62 64 66 69 ] In the 24-week initiation phase of the Durability of Basal versus LM 75/25 Insulin Efficacy (DURABLE) study comparing LM 25 bid with glargine od, each in addition to OADs, LM 25 significantly decreased HbA1c and was associated with lower PPG levels after morning and evening meals. [ 66 ] However, the incidence of hypoglycemia was significantly greater with LM 25, as was weight gain.…”

Section: O Verview Of R Andomized mentioning

confidence: 99%

See 1 more Smart Citation

Efficacy and safety of biphasic insulin aspart and biphasic insulin lispro mix in patients with type 2 diabetes: A review of the literature

Kumar

2016

Indian J Endocr Metab

View full text Add to dashboard Cite

Type 2 diabetes (T2D) represents an escalating burden worldwide, particularly in China and India. Compared with Caucasians, Asian people with diabetes have lower body mass index, increased visceral adiposity, and postprandial glucose (PPG)/insulin resistance. Since postprandial hyperglycemia contributes significantly to total glycemic burden and is associated with heightened cardiovascular risk, targeting PPG early in T2D is paramount. Premixed insulin regimens are widely used in Asia due to their convenience and effectiveness. Data from randomized controlled trials and observational studies comparing efficacy and safety of biphasic insulin aspart 30 (BIAsp 30) with biphasic insulin lispro mix (LM 25/50) and versus other insulin therapies or oral antidiabetic drugs (OADs) in T2D demonstrated that BIAsp 30 and LM 25/50 were associated with similar or greater improvements in glycemic control versus comparator regimens, such as basal–bolus insulin, in insulin-naÏve, and prior insulin users. Studies directly comparing BIAsp 30 and LM 25 provided conflicting glycemic control results. Safety data generally showed increased hypoglycemia and weight gain with premixed insulins versus basal–bolus insulin or OADs. However, large observational trials documented improvements in glycated hemoglobin, PPG, and hypoglycemia with BIAsp 30 in multi-ethnic patient populations. In summary, this literature review demonstrates that premixed insulin regimens are an appropriate and effective treatment choice in T2D.

show abstract

Section: B Iphasic I Nsulin L mentioning

confidence: 99%

Section: O Verview Of R Andomized mentioning

confidence: 99%

Efficacy and safety of biphasic insulin aspart and biphasic insulin lispro mix in patients with type 2 diabetes: A review of the literature

Kumar

2016

Indian J Endocr Metab

View full text Add to dashboard Cite

show abstract

“…Hyperglycemia is characterized by abnormal increases in postprandial blood glucose and is complicit in the etiology of type-2 diabetes [40, 41]. Increased activities of pancreatic α -amylase and intestinal α -glucosidase enzymes involved in starch hydrolysis have been reported in experimental diabetic animal models [42].…”

Section: Discussionmentioning

confidence: 99%

Interaction of Some Commercial Teas with Some Carbohydrate Metabolizing Enzymes Linked with Type-2 Diabetes: A Dietary Intervention in the Prevention of Type-2 Diabetes

Oboh

Ogunruku

Ogidiolu

et al. 2014

Advances in Preventive Medicine

View full text Add to dashboard Cite

This study is aimed at assessing the inhibitory effect of teas on key enzymes (α-amylase and α-glucosidase) linked with type-2 diabetes and their antioxidant properties. Four samples of three brands were used; infusions of green tea (GT), 2 brands of black tea (BT), and a formulated herbal preparation for diabetes (ADT) (white tea, Radix Puerariae, Radix ophiopogonis, hawthorn berry, Chinese yam, and fragrant Solomon seal rhizome) were prepared and subsequently analyzed for their total phenol, ascorbic acid contents, antioxidant properties (2,2-Azizobis (3-Ethylbenzo-Thiazoline~6-sulfonate) “ABTS” scavenging ability and ferric reducing antioxidant property), and inhibition of pancreatic-α-amylase and intestinal-α-glucosidase in vitro. The study revealed that GT had the highest total phenol content, ascorbic acid content, ABTS∗ scavenging ability, and ferric reducing ability. Furthermore, all the teas inhibited Fe2+ and sodium nitroprusside induced lipid peroxidation in pancreas, with GT having the highest inhibitory effect. Conversely, there was no significant difference (P > 0.05) in the inhibitory effects of the teas on α-amylase and α-glucosidase. The antidiabetic property of the teas could be attributed to their inhibitory effect on carbohydrate hydrolyzing enzymes implicated in diabetes and their antioxidant activities.

show abstract

“…Gla-100 vs. Premixed Insulins Twenty studies reported insulin initiation and compared the outcomes between Gla-100 and premixed insulins [7,[10][11][12][13][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41]. In a majority of studies (n = 19), the insulins were co-administered with OADs [7, 10-13, 27-37, 39-41] (Table 3).…”

Section: Safety Outcomes Primary Outcomes Hypoglycemic Eventsmentioning

confidence: 99%

Twenty Years of Insulin Gla-100: A Systematic Evaluation of Its Efficacy and Safety in Type 2 Diabetes Mellitus

Sethi

Unnikrishnan²,

Ayyar

et al. 2022

Diabetes Ther

View full text Add to dashboard Cite

Introduction: This systematic review aims to present the current evidence base with respect to the initiation and intensification of insulin therapy with glargine 100 U/mL (Gla-100) compared to other insulins in people with type 2 diabetes mellitus (T2DM).Methods: A systematic literature search of PubMed (MEDLINE), EMBASE, and the Cochrane Central Register of controlled clinical trials databases was performed to identify studies published up to September 30, 2020 that compared the effects of Gla-100 to that of other insulin regimens in people with T2DM. Relevant information pertaining to the predefined outcomes of interest was extracted. Glycated hemoglobin (HbA1c) change and response rates along with overall hypoglycemia incidence were the primary efficacy and safety outcomes of interest.

show abstract

Effects on post-prandial glucose and AGE precursors from two initial insulin strategies in patients with Type 2 diabetes uncontrolled by oral agents

Cited by 8 publications

References 28 publications

Efficacy and safety of biphasic insulin aspart and biphasic insulin lispro mix in patients with type 2 diabetes: A review of the literature

Efficacy and safety of biphasic insulin aspart and biphasic insulin lispro mix in patients with type 2 diabetes: A review of the literature

Interaction of Some Commercial Teas with Some Carbohydrate Metabolizing Enzymes Linked with Type-2 Diabetes: A Dietary Intervention in the Prevention of Type-2 Diabetes

Twenty Years of Insulin Gla-100: A Systematic Evaluation of Its Efficacy and Safety in Type 2 Diabetes Mellitus

Contact Info

Product

Resources

About