Interaction of Some Commercial Teas with Some Carbohydrate Metabolizing Enzymes Linked with Type-2 Diabetes: A Dietary Intervention in the Prevention of Type-2 Diabetes

Abstract

This study is aimed at assessing the inhibitory effect of teas on key enzymes (α-amylase and α-glucosidase) linked with type-2 diabetes and their antioxidant properties. Four samples of three brands were used; infusions of green tea (GT), 2 brands of black tea (BT), and a formulated herbal preparation for diabetes (ADT) (white tea, Radix Puerariae, Radix ophiopogonis, hawthorn berry, Chinese yam, and fragrant Solomon seal rhizome) were prepared and subsequently analyzed for their total phenol, ascorbic acid contents, antioxidant properties (2,2-Azizobis (3-Ethylbenzo-Thiazoline~6-sulfonate) “ABTS” scavenging ability and ferric reducing antioxidant property), and inhibition of pancreatic-α-amylase and intestinal-α-glucosidase in vitro. The study revealed that GT had the highest total phenol content, ascorbic acid content, ABTS∗ scavenging ability, and ferric reducing ability. Furthermore, all the teas inhibited Fe2+ and sodium nitroprusside induced lipid peroxidation in pancreas, with GT having the highest inhibitory effect. Conversely, there was no significant difference (P > 0.05) in the inhibitory effects of the teas on α-amylase and α-glucosidase. The antidiabetic property of the teas could be attributed to their inhibitory effect on carbohydrate hydrolyzing enzymes implicated in diabetes and their antioxidant activities.

Black tea extract improves anti-oxidant profile in experimental diabetic rats

“…Significantly, black tea is the most commonly consumed beverage and is reported to possess potent anti-oxidant properties (Abeywickrama et al, 2011). The anti-diabetic effect of teas has also been explored based on the inhibitory effect of teas on key enzymes (a-amylase and a-glucosidase) linked with type-2 diabetes (Oboh et al, 2014). It has been hypothesized that black tea could be useful as a functional food in the dietary therapy for borderline type 2 diabetes mellitus that could modulate postprandial hyperglycaemia (Satoh et al, 2015).…”

Hesperidin supplementation has no effect on blood glucose control: A systematic review and meta‐analysis of randomized controlled clinical trials

“…Type 2 diabetes mellitus (T2DM) is a common chronic disease characterized by abnormal glucose metabolism . The dramatic increase in T2DM prevalence is considered a global public health concern .…”