Effects on Blood Pressure Decrease in Response to PAF of Impatiens textori MIQ.

Ueda, Yoshimi; Oku, Hisae; Iinuma, Munekazu; Ishiguro, Kyoko

doi:10.1248/bpb.26.1505

Cited by 29 publications

(19 citation statements)

References 12 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5,6) We also developed a more rapid assay systems using the blood pressure monitoring system. [7][8][9] Herein, we report that the blood flow of vein microcirculation is markedly decrease by HEL-sensitization alone without the HEL-challenge. There has been no report of the blood flow of vein microcirculation being involved in an initial stage of the immune reaction.…”

mentioning

confidence: 78%

Development of an in Vivo Bioassay Method for Allergy-Preventive Substances Using Hen-Egg White Lysozyme (HEL)-Induced Blood Flow Decrease

Ishiguro

Oku

Ueda

et al. 2005

Biological & Pharmaceutical Bulletin

Self Cite

View full text Add to dashboard Cite

We discovered a phenomenon in which the blood flow in vein microcirculation markedly decreases in response to hen-egg white lysozyme (HEL)-sensitization without any change in blood pressure. Using this blood flow decrease as a guide, we developed an in vivo assay method to search for substances, which can prevent allergies. Antagonists of histamine, serotonin and platelet activating factor (PAF) did not affect the blood flow decrease in response to HEL-sensitization. On the other hand, cyclooxygenase (COX)-1, COX-2, thromboxane (TX) A 2 , endothelin-1 (ET-1), prostacyclin (PGI 2 ) and granulocytic elastase (GE) as well as nitric oxide (NO) from inducible NO synthase (iNOS) were involved in the blood flow decrease. Thus, these substances might injure vascular endothelial cells, and cause a decrease in blood flow in vein microcirculation. Our method can be used to search for preventive agents against allergies involving NO, COX-1, 2 and PGI 2 . This is the first report to applying to an assay method the specific blood flow decrease to occur in the promotion stage of allergy.

show abstract

mentioning

confidence: 78%

Development of an in Vivo Bioassay Method for Allergy-Preventive Substances Using Hen-Egg White Lysozyme (HEL)-Induced Blood Flow Decrease

Ishiguro

Oku

Ueda

et al. 2005

Biological & Pharmaceutical Bulletin

Self Cite

View full text Add to dashboard Cite

show abstract

“…We previously reported the inhibitory effects of IT on established allergy such as antianaphylactic, antipruritic, and anti-PAF activity. 2,3) Thus this flower could be useful during the preventive and therapeutic stages of allergy.…”

Section: Discussionmentioning

confidence: 99%

“…2,3) Apigenin (1), apigenin 7-glucoside (2), luteolin (3), luteolin 7-glucoside (4), quercetin (5), kaempferol (6), and kaempferol 3-glucoside (7) were isolated from IT as previously reported.…”

Section: Methodsmentioning

confidence: 99%

Allergy-Preventive Effects of the Flowers of Impatiens textori

Iwaoka

Oku

Iinuma

et al. 2010

Biological & Pharmaceutical Bulletin

Self Cite

View full text Add to dashboard Cite

Whole plant of Impatiens textori MIQ. (Balsaminaceae) is an annual herbaceous plant that grows naturally along waterfronts in the mountains in almost every region of Japan. It has been used for detoxication and treatment of carbuncles and contusions in Chinese medicine. 1) However, there has been no report on the antiallergic effects of the flowers of I. textori. In a previous study, we demonstrated the antianaphylactic, antipruritic, and antiplatelet activating factor (PAF) activities of a 35% EtOH extract (IT) of the flowers of I. textori, and isolated apigenin (1), apigenin 7-glucoside (2), luteolin (3), luteolin 7-glucoside (4), quercetin (5), kaempferol (6), and kaempferol 3-glucoside (7). 2,3)In a continuing search for allergy-preventive substances from natural sources, using our previously developed in vivo assay method to estimate complicated allergy, 4) we found that IT exhibited allergy-preventive activity. This in vivo assay method monitors the decrease in blood flow in the tail vein of mice subjected to hen egg-white lysozyme (HEL) sensitization alone without the HEL challenge as a guide.4) The blood flow in HEL-sensitized mice (control group) gradually and significantly decreased to about 70% of that in normal mice on day 9. Thus, the induction phase of allergy caused by xenobiotics can be dynamically and easily measured using blood flow monitoring. This blood flow decrease is considered to be due to the contraction of peripheral blood vessels and increase in blood viscosity, because no relationship with blood pressure was observed. Although anti-HEL immunoglobulin E (IgE) antibody significantly increased after HEL sensitization, there was no significant increase in the number of leukocytes. Thus the decrease in blood flow reflects the promoter process of an allergic reaction. The blood flow decrease is regulated by various factors such as nitric oxide (NO), thromboxane (TX) A 2 , prostacyclin (PGI 2 ), and endothelin (ET)-1, together with granulocytic elastase (GE), cyclooxygenase (COX)-1 and -2, inducible nitric oxide synthase (iNOS), and constitutive nitric oxide synthase (cNOS). 4) Additionally, the blood flow decrease occurs via both pathways of the iNOS-independent and -dependent response.5) Therefore this monitoring system should be useful for searching for preventive substances against complicated allergy involving NO, TXA 2 , PGI 2 , ET-1, GE, COX-1, and COX-2. 4,5) This paper describes the evaluation of the allergy-preventive effects of a 35% EtOH extract (IT) of the flowers of I. textori and compounds (1-7) previously isolated from IT. MATERIALS AND METHODS MaterialsThe 35% EtOH extract (IT) of the flowers of I. textori was used for our present and previous studies. 2,3)Apigenin (1), apigenin 7-glucoside (2), luteolin (3), luteolin 7-glucoside (4), quercetin (5), kaempferol (6), and kaempferol 3-glucoside (7) were isolated from IT as previously reported.2) HEL and complete Freund's adjuvant (CFA) were purchased from Sigma Chemical (St. Louis, MO, U.S.A.), Difco (Detroit, Michigan, U.S.A.)...

show abstract

“…A 35% EtOH extract of flowers of Impatiens textori showed an inhibitory effect on blood pressure decrease in response to platelet activating factor measured with a blood pressure monitoring system. Bioassay-guided fractionation of the 35% EtOH extract of Impatiens textori led to isolation of the flavones apigenin and luteolin, which significantly inhibited blood pressure decrease in response to platelet activating fector (Ueda Y et al, 2003).…”

Section: Anti Platelet Activating Activitymentioning

confidence: 99%

Phytochemical and Pharmacological Significance of Genus: Impatiens

Singh¹,

Singh²,

Sati³

et al. 2017

IJLSSR

View full text Add to dashboard Cite

ABSTRACT-The genus Impatiens (Compositae) was reviewed for its chemical constituents and biological significance and its traditional uses. The genus has been known for its various biological activities like: antimicrobial activity, antioxidant activity, antiallergic activity, antipruritic activity, antidermatitic activity, transcriptional activity, anti-rheumatoid arthritis activity, anti-histamine activity, testosterone 5α-reductase inhibitory activity, cyclooxygenase-2 inhibitory activity and anti platelet activating activity. Most of the plants of this genus are rich sources of napthoquinones, flanonoids, glycosides and sapogenins. The bioactive constituents or plants extracts may be uses for treatment of various diseases and these would be used as a new formulation for the novel drugs discovery in pharmaceutical industries. This review presents comprehensive information on the chemistry and pharmacology of the genus together with the traditional uses of many of its plants. In addition, this review discusses the structure-activity relationship of different compounds as well as recent developments and the scope for future research in this aspect.

show abstract

Effects on Blood Pressure Decrease in Response to PAF of Impatiens textori MIQ.

Cited by 29 publications

References 12 publications

Development of an in Vivo Bioassay Method for Allergy-Preventive Substances Using Hen-Egg White Lysozyme (HEL)-Induced Blood Flow Decrease

Development of an in Vivo Bioassay Method for Allergy-Preventive Substances Using Hen-Egg White Lysozyme (HEL)-Induced Blood Flow Decrease

Allergy-Preventive Effects of the Flowers of Impatiens textori

Phytochemical and Pharmacological Significance of Genus: Impatiens

Contact Info

Product

Resources

About