Effects on adhesiveness and hydrophobicity of sub-inhibitory concentrations of netilmicin

Furneri, Pio Maria; Garozzo, A; Musumarra, Maria Pia; Scuderi, Anna Claudia; Russo, Andrea; Bonfiglio, Giovanni

doi:10.1016/s0924-8579(03)00149-3

Cited by 22 publications

(15 citation statements)

References 12 publications

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“…However, there was a significant increase in the cell population and the MIC values on exposure to sub-MIC of ceftriaxone. Studies have indicated that the exposure of patients to subinhibitory concentrations of antimicrobial agents may induce various changes in bacterial and yeast properties, including morphological or ultrastructure changes and inhibition or stimulation of enzyme and toxin production (Furneri et al, 2003). Our findings were consistent with these earlier reports and demonstrated that there was an indirect alteration of phagocyte activity of plasma by modulation of bacterial pathogenicity.…”

Section: Discussionsupporting

confidence: 92%

Survival patterns of some common pathogens in human plasma following exposure to a sub-inhibitory concentration of ceftriaxone sodium

Okore¹,

Nduka²,

Ogbu³

2010

International Journal of Biological and Chemical Sciences

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The survival of Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa in human plasma was investigated following their exposure to a sub-inhibitory concentration of ceftriaxone sodium. The aim was to determine the possible effect of human immune agents present in the plasma on microorganisms that may have been previously exposed to sub-inhibitory concentrations of antibiotics. Microbial survival was assessed by viable cell counts conducted at hourly intervals over a period of 5 hours. Subsequently, surviving organisms were used to determine the minimal inhibitory concentration of the antibiotics. The results showed that the rate of replication of P. aeruginosa in plasma was significantly reduced after exposure to a subinhibitory concentration of ceftriaxone sodium. On the contrary, there was an increase in the minimum inhibitory concentration of the antibiotic after K. pneumoniae or E. coli were exposed to the sub-inhibitory antibiotic concentration. This implies that, while some organisms were weakened by sub-lethal doses of ceftriaxone sodium to the extent of susceptibility to human immune agents, others gained resistance to both the antibiotic and the immune system.

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Section: Discussionsupporting

confidence: 92%

Survival patterns of some common pathogens in human plasma following exposure to a sub-inhibitory concentration of ceftriaxone sodium

Okore¹,

Nduka²,

Ogbu³

2010

International Journal of Biological and Chemical Sciences

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“…It has been suggested that if a low concentration of antibiotics or other drugs is able to prevent initial adherence of bacteria to surfaces, the subsequent step of biofilm formation would also be inhibited [12]. A similar conclusion might be drawn for other possible interventions being considered to reduce the incidence of device-related infections, such as use of biomaterials with low intrinsic binding of microbes.…”

Section: Discussionmentioning

confidence: 91%

“…Several strategies have been proposed to inhibit biofilm formation on medical devices, including the administration of sub-MICs of antibiotics [5,12,17], use of furanone compounds [4], anti-inflammatory drugs [3], bacterial extracts [14], development of new anti-adhesive medical surfaces [8,22] and coating medical devices with several different compounds, including antibiotics [16,21,28].…”

Section: Introductionmentioning

confidence: 99%

“…Sub-MICs of antibiotics have been successfully used to inhibit bacterial initial adhesion to abiotic substrates [17] and it was suggested that these studies could provide insights into preventing biofilm formation on medical devices [12]. Several studies have already demonstrated that initial adherence to a surface and subsequent biofilm formation can be two independent phenomena [32], and so conclusions drawn regarding an effect of sub-MIC antibiotics on initial bacterial adherence may not be directly extrapolated to biofilm formation.…”

Section: Introductionmentioning

confidence: 99%

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The relationship between inhibition of bacterial adhesion to a solid surface by sub-MICs of antibiotics and subsequent development of a biofilm

Cerca¹,

Martins²,

Pier³

et al. 2005

Research in Microbiology

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Many studies have demonstrated that subminimal inhibitory concentrations (sub-MICs) of antibiotics can inhibit initial microbial adherence to medical device surfaces. It has been suggested that, by inhibiting initial adhesion, biofilm formation might be prevented. However, since initial adherence and subsequent biofilm formation may be two distinct phenomena, conclusions regarding the effects of sub-MIC antibiotics on initial adhesion cannot be extrapolated to biofilm formation. In this study, we evaluated the adherence of several clinical isolates of coagulase-negative staphylococci (CoNS) to acrylic and the effect of sub-MICs of vancomycin, cefazolin, dicloxacillin and combinations of these antibiotics on adherence and biofilm formation. Most of the antibiotics used resulted in effective reduction of bacterial adherence to acrylic, in some cases reaching over 70% inhibition of adherence. When strains with a high biofilm-forming capacity were grown in sub-MICs of those antibiotics, there existed combinations of the drugs that significantly inhibited biofilm formation. However, most of the antibiotic combinations that inhibited adherence did not have a profound effect on biofilm formation. When comparing the results of the effect of sub-MIC amounts of antibiotics in inhibiting adherence with their effect on the inhibition of biofilm formation, significant differences were found, mainly when using combinations of antibiotics. In general, the effect on the inhibition of adherence was greater than the effect on inhibiting biofilm formation. These results demonstrate that assays evaluating the inhibition of initial adherence to medical surfaces cannot fully predict the effect on inhibition of biofilm formation.

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“…The infections due to these bacteria are particularly difficult to eradicate because the infectious agent may acquire different mechanisms of resistance for which the use of the common antibiotic therapy is ineffective. One study has shown how in these cases the use of drugs such as netilmicin is able to reduce the adhesiveness, hydrophobic interactions, fimbriation or motility of the bacteria, although it is not able to kill them, thus reducing the risk of infections or the development of severe infectious diseases (9). …”

Section: Introductionmentioning

confidence: 99%

The risk of HCV infection among health-care workers and its association with extrahepatic manifestations

Garozzo

Falzone

Rapisarda

et al. 2017

Molecular Medicine Reports

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Health care workers (HCWs) are frequently exposed to different biological agents during their activities and are frequently monitored. Among these infectious agents, human hepatitis C (HCV) can infect HCWs. In this review article, the risk of HCV infection among HCWs is discussed along with extrahepatic HCV-related malignancies, such as non-Hodgkin lymphoma. Accidental contamination, represented by percutaneous and mucocutaneous infections is the main risk factor for such infection. The compliance of the protection procedures, included in the current regulation for HCWs, is the most important issue to reduce the risk of pathogen infections that in turn may produce reduction of infection-associated malignancies.

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Effects on adhesiveness and hydrophobicity of sub-inhibitory concentrations of netilmicin

Cited by 22 publications

References 12 publications

Survival patterns of some common pathogens in human plasma following exposure to a sub-inhibitory concentration of ceftriaxone sodium

Survival patterns of some common pathogens in human plasma following exposure to a sub-inhibitory concentration of ceftriaxone sodium

The relationship between inhibition of bacterial adhesion to a solid surface by sub-MICs of antibiotics and subsequent development of a biofilm

The risk of HCV infection among health-care workers and its association with extrahepatic manifestations

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