Effects of ω‐3 Fish Oil Lipid Emulsion Combined With Parenteral Nutrition on Patients Undergoing Liver Transplantation

Zhu, Xinhua; Wu, Yuzhong; Qiu, Yudong; Jiang, Chunping; Ding, Yitao

doi:10.1177/0148607112440120

Cited by 43 publications

(52 citation statements)

References 19 publications

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“…In clinical practice, the administration of a fish oil lipid emulsion combined with parenteral nutrition has been shown to decrease the incidence of infectious morbidities following orthotopic liver transplantation [18]. In another study, a significantly lower rate of infections, fewer complications, and a shorter length of hospital stay was demonstrated in a group of 230 postsurgical patients who received parenteral nutrition including fish oil for at least 3 days [19].…”

Section: Omega-3 Polyunsaturated Fatty Acid-supplemented Nutritionmentioning

confidence: 98%

Nutrition and Sepsis

Cohen¹,

Chin²

2012

World Review of Nutrition and Dietetics

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The effect of nutritional support in critically ill patients with sepsis has received much attention in recent years. However, many of the studies have produced conflicting results. As for all critically ill patients, nutritional support, preferably via the enteral route, should be commenced once initial resuscitation and adequate perfusion pressure is achieved. Where enteral feeding is impossible or not tolerated, parenteral nutrition (either as total or complimentary therapy) may safely be administered. Most positive studies relating to nutritional support and sepsis have been in the setting of sepsis prevention. Thus, the administration of standard nutrition formulas to critically ill patients within 24 h of injury or intensive care unit admission may decrease the incidence of pneumonia. Both arginine-supplemented enteral diets, given in the perioperative period, and glutamine-supplemented parenteral nutrition have been shown to decrease infections in surgical patients. Parenteral fish oil lipid emulsions as well as probiotics given in the perioperative period may also reduce infections in patients undergoing major abdominal operations, such as liver transplantation. There is little support at the present time for the positive effect of specific pharmaconutrients, in particular fish oil, probiotics, or antioxidants, in the setting of established sepsis. More studies are clearly required on larger numbers of more homogeneous groups of patients.

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Section: Omega-3 Polyunsaturated Fatty Acid-supplemented Nutritionmentioning

confidence: 98%

Nutrition and Sepsis

Cohen¹,

Chin²

2012

World Review of Nutrition and Dietetics

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“…Three trials, including one identified after the systematic review was published [4], addressed the use of parenteral nutrition after transplantation. No effect of the intervention was observed with regard to mortality or serum bilirubin [2 && ].…”

Section: Liver Transplantationmentioning

confidence: 99%

“…Association may be caused by other confounding factors; for example, malnourished patients may simply have more severe disease. A subsequent search in August 2013 identified three additional RCTs [4][5][6]. This paper will review the RCTs that have been reported to date that have assessed the utility of various nutritional interventions [parenteral nutrition, enteral nutrition, or nutritional supplements (containing at least a source of nitrogen and nonprotein calories)] in patients with liver disease.…”

Section: Introductionmentioning

confidence: 99%

The evidence for the use of nutritional support in liver disease

Koretz

2014

Current Opinion in Gastroenterology

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Although malnutrition may be associated with a poor outcome, the current best evidence indicates that the provision of adjunctive nutritional support (parenteral or enteral nutrition, or nutritional supplements) to patients with a variety of liver diseases (alcoholic hepatitis, cirrhosis, hepatocellular carcinoma, liver surgery, liver transplantation, obstructive jaundice, hepatitis C antiviral treatment) does not improve clinical outcomes.

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“…It may also decrease the incidence of rejection, but the mechanisms involved remain unknown [27,28]. Supplementation of omega-3 FA may also reduce occurrence of new-onset diabetes mellitus [29], reduce infectious morbidities, and shorten post-transplantation hospital stays [21,30].…”

Section: Discussionmentioning

confidence: 99%