Effects of zinc supplementation on superoxide dismutase activity and gene expression, and metabolic parameters in overweight type 2 diabetes patients: A randomized, double-blind, controlled trial

Nazem, Mohammad Reza; Asadi, Mojgan; Jabbari, Niloofar; Allameh, Abdolamir

doi:10.1016/j.clinbiochem.2019.05.008

Cited by 50 publications

(23 citation statements)

References 38 publications

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“…We also demonstrated that oral supplementation of Zn improved Zn deficiency-associated PUs in our cutaneous I/R injury mice model. A randomized, double-blind, placebo-controlled trial has reported that Zn supplementation increases the enzymatic activity of SOD in blood in patients with type 2 diabetes mellitus, suggesting that supplementation of Zn might also be useful in patients with PUs [42]. Our results strongly suggest the clinical significance of monitoring the serum Zn levels inpatients with PUs and elderly patients at a high risk of PUs, and Zn supplementation in patients with PUs and Zn deficiency.…”

Section: Discussionsupporting

confidence: 55%

Zinc deficiency exacerbates pressure ulcers by increasing oxidative stress and ATP in the skin

Nakamura

Sekiguchi

Ogawa

et al. 2019

Journal of Dermatological Science

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Section: Discussionsupporting

confidence: 55%

Zinc deficiency exacerbates pressure ulcers by increasing oxidative stress and ATP in the skin

Nakamura

Sekiguchi

Ogawa

et al. 2019

Journal of Dermatological Science

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“…The inflammatory mechanism indicates a direct relationship between inflammatory status and obesity [ 40 ]. Thus, in the IG, independent of the decrease in total energy intake, the significant increase of serum zinc levels led to a reduction of inflammation and consequently weight loss [ 41 ]. A meta-analysis showed no significant changes in anthropometric measures after zinc supplementation (ranged from 4 to 48 week, in different disease) in the overall analysis [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…According to previous study, insufficient data about the effect of zinc supplementation on anthropometric indices in migraine patients has been reported [ 42 ], that needs to be evaluated in the future studies. Among possible mechanisms involved in weight loss following zinc supplementation can be mentioned the role of zinc in regulating appetite by altering the metabolism of hypothalamic neurotransmitters and increasing leptin secretion, inhibiting gene mutations leading to obesity, improving insulin sensitivity and reduction of inflammation [ 41 43 44 45 ].…”

Section: Discussionmentioning

confidence: 99%

Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women

et al. 2021

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Migraine is a widespread incapacitating neurologic disorder with debilitating headaches which are usually throbbing due to inefficacy and several side effects, complementary therapies recommended as possible alternatives. The current randomized controlled trial was carried out to evaluate the effect of zinc gluconate supplementation on migraine-related symptoms, serum level of high sensitivity C-reactive protein (hs-CRP) and lipid profile in migraineurs. Present study was designed as randomized double-blind, placebo-controlled trial. Sixty women with migraine (mean age of 35.44 ± 7.42 years ) were randomly allocated to obtain 15 mg per day of zinc gluconate or placebo for 12 weeks. Frequency, periods of headaches and severity of migraine based on numerical rating scale questionnaire and migraine disability assessment (MIDAS) test were checked. Fasting serum level of lipid profile and hs-CRP were assessed at the beginning and the end of trial. Zinc gluconate supplementation significantly reduced the frequency (p = 0.001), periods of migraine attacks (p < 0.001) and severity of migraine and MIDAS (p < 0.001) compared with control group. The serum level of low-density lipoprotein (p < 0.001), total cholesterol (p < 0.001) and hs-CRP (p < 0.001) decreased following zinc supplementation, but no significant differences in serum level of triglycerides (p = 0.1) and high-density lipoprotein (p = 0.3) was observed. However, after adjustment for baseline values using analysis of covariance test, none of lipid profile components and hs-CRP showed a significant difference. Zinc supplementation has beneficial effect on the migraine related complications like its severity, frequency. Trial Registration Iranian Registry of Clinical Trials Identifier: IRCT20191014045100N1

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“…One study identified a circulating biomarker for treatment response. A clinical trial administered placebo or zinc supplementation in overweight T2D patients and profiled SOD1 expression in leukocytes [ 72 ]. The mRNA levels were significantly elevated in patients who received supplementation, compared to placebo and levels before treatment, and correlated with serum zinc concentrations.…”

Section: Transcriptomics Biomarkers Of T2dmentioning

confidence: 99%

Circulating Nucleic Acid-Based Biomarkers of Type 2 Diabetes

Padilla-Martínez

Wojciechowska

Szczerbiński

et al. 2021

IJMS

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Type 2 diabetes (T2D) is a deficiency in how the body regulates glucose. Uncontrolled T2D will result in chronic high blood sugar levels, eventually resulting in T2D complications. These complications, such as kidney, eye, and nerve damage, are even harder to treat. Identifying individuals at high risk of developing T2D and its complications is essential for early prevention and treatment. Numerous studies have been done to identify biomarkers for T2D diagnosis and prognosis. This review focuses on recent T2D biomarker studies based on circulating nucleic acids using different omics technologies: genomics, transcriptomics, and epigenomics. Omics studies have profiled biomarker candidates from blood, urine, and other non-invasive samples. Despite methodological differences, several candidate biomarkers were reported for the risk and diagnosis of T2D, the prognosis of T2D complications, and pharmacodynamics of T2D treatments. Future studies should be done to validate the findings in larger samples and blood-based biomarkers in non-invasive samples to support the realization of precision medicine for T2D.

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Effects of zinc supplementation on superoxide dismutase activity and gene expression, and metabolic parameters in overweight type 2 diabetes patients: A randomized, double-blind, controlled trial

Cited by 50 publications

References 38 publications

Zinc deficiency exacerbates pressure ulcers by increasing oxidative stress and ATP in the skin

Zinc deficiency exacerbates pressure ulcers by increasing oxidative stress and ATP in the skin

Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women

Circulating Nucleic Acid-Based Biomarkers of Type 2 Diabetes

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