2021
DOI: 10.7762/cnr.2021.10.2.127
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Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women

Abstract: Migraine is a widespread incapacitating neurologic disorder with debilitating headaches which are usually throbbing due to inefficacy and several side effects, complementary therapies recommended as possible alternatives. The current randomized controlled trial was carried out to evaluate the effect of zinc gluconate supplementation on migraine-related symptoms, serum level of high sensitivity C-reactive protein (hs-CRP) and lipid profile in migraineurs. Present study was designed as randomized double-blind, p… Show more

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Cited by 12 publications
(14 citation statements)
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“…42 Oral zinc supplementation reduced migraine severity and frequency in previous randomized controlled trials. 12,13 However, few studies assessed the effects of dietary zinc intake on migraine in the US population. The present study demonstrated an inverse relationship between dietary zinc intake and migraine.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…42 Oral zinc supplementation reduced migraine severity and frequency in previous randomized controlled trials. 12,13 However, few studies assessed the effects of dietary zinc intake on migraine in the US population. The present study demonstrated an inverse relationship between dietary zinc intake and migraine.…”
Section: Discussionmentioning
confidence: 99%
“…Dhillon et al treated individuals living with migraine disease with 75 mg of zinc sulfate and vitamins for 6 weeks with a good response 42 . Oral zinc supplementation reduced migraine severity and frequency in previous randomized controlled trials 12,13 . However, few studies assessed the effects of dietary zinc intake on migraine in the US population.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…A comprehensive systematic review and meta-analysis conducted by Asbaghi et al [ 74 ] showed that lipid profiles may be affected by zinc supplementation. In women with migraines, serum LDL and TCH levels also decreased after zinc supplementation [ 75 ]. Zinc supplementation also decreased ALT and AST levels in rats with nonalcoholic steatohepatitis [ 76 ].…”
Section: Discussionmentioning
confidence: 99%
“…22 This study was also supported by an assessment study of the effect of Zinc in adult women for 12 weeks and revealed similar results as Zinc supplementation have promising effects on migraine frequency and severity. 23 Although these studies are preliminary with a limited number of patients and duration, an investigation with varying dosage and a more extended period of Zinc intervention may reveal a robust understanding of dietary Zinc for migraineurs.…”
Section: Zinc Deficiency As a Trigger Of Migraine Womenmentioning
confidence: 99%