Effects of Zinc on Interleukins and Antioxidant Enzyme Values in Psoriasis-Induced Mice

Yin, Liang; Zhang, Y.; Guo, Dongmei; An, Kalinin; Yin, Meng; Chen, Xi

doi:10.1007/s12011-013-9799-0

Cited by 18 publications

(12 citation statements)

References 30 publications

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“…Heat stress may also make the body secrete excessive glucocorticoid, which can promote the body’s decomposition of proteins and thus cause cell damage. Vitamin C can regulate the secretion of the glucocorticoid and relieve the cell damage caused by heat stress [42]. Zinc is a major component of the copper–zinc superoxide dismutase (CuZn-SOD) which plays a vital role in antioxidant defense systems [42].…”

Section: Heat Stress and Oxidative Stressmentioning

confidence: 99%

“…Vitamin C can regulate the secretion of the glucocorticoid and relieve the cell damage caused by heat stress [42]. Zinc is a major component of the copper–zinc superoxide dismutase (CuZn-SOD) which plays a vital role in antioxidant defense systems [42]. Glutathione peroxidase is a selenium-dependent enzyme, meaning more selenium is needed when the body is under heat stress.…”

Section: Heat Stress and Oxidative Stressmentioning

confidence: 99%

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Polyphenols as Potential Attenuators of Heat Stress in Poultry Production

Arowolo

et al. 2019

Antioxidants

107

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Heat stress is a non-specific physiological response of the body when exposed to high ambient temperatures, which can break the balance of body redox and result in oxidative stress that affects growth performance as well as the health of poultry species. Polyphenols have attracted much attention in recent years due to their antioxidant ability and thus, can be an effective attenuator of heat stress. In this paper, the potential mechanisms underlying the inhibitory effect of polyphenols on heat stress in poultry has been reviewed to provide a reference and ideas for future studies related to polyphenols and poultry production.

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Section: Heat Stress and Oxidative Stressmentioning

confidence: 99%

Section: Heat Stress and Oxidative Stressmentioning

confidence: 99%

Polyphenols as Potential Attenuators of Heat Stress in Poultry Production

Arowolo

et al. 2019

Antioxidants

107

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confidence: 99%

“…Zinc plays an important role in maintaining the antioxi dant enzyme activities in tissues, protecting the cells against oxidative stress, and scavenging the free radicals [20,25,26]. The Znrelated antioxidant enzymes, including GSHPx and SOD, could limit the effects of reactive oxygen species on tis sues and are active in defense against oxidative cell damage [25]. In our study, 1,200 or 1,800 mg/kg Zn as TBZC supple mentation in diets increased the activities of GSHPX and T AOC in liver, which is in accordance with other reports that dietary supplementation with appropriate concentrations of Zn could improve liver antioxidant capacity and help main tain liver health [14,26].…”

mentioning

confidence: 99%

“…On the other hand, the MDA content showed opposite change with the aforementioned antioxi dant enzyme activities. The MDA is a critical indicator for lipid peroxidation and oxidative damage caused by reactive oxygen species, which would influence cell membrane fluidity as well as the integrity of biomolecules [25,26]. Increased MDA content caused by high dietary Zn concentration is reported to be associated with lower antioxidant enzyme activities, and also associated with the oxidative cell damage in liver, which would allow ALT and AST to permeate into blood due to increased cell membrane permeability [25].…”

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confidence: 99%

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Moderate tetrabasic zinc chloride supplementation improves growth performance and reduces diarrhea incidence in weaned pigs

Zhang

Xia

Zhao

et al. 2020

Asian-Australas J Anim Sci

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Objective: Two experiments were conducted to evaluate tetrabasic zinc chloride (TBZC) on the health of weaned pigs, and to determine the optimal supplemental concentrations and whether dietary TBZC could replace the pharmacological concentrations of dietary zinc oxide (ZnO) to improve growth performance and decrease Zn excretion in weaned pigs. Methods: In Exp. 1, 180 weaned pigs (8.92±1.05 kg body weight [BW]) were randomly assigned to 1 of 5 treatments, including the basal diet containing 125 mg/kg zinc sulfate (ZnSO 4), and the basal diet with 1,200, 1,800, 2,400, or 3,000 mg/kg TBZC supplementation. In Exp. 2, 240 weaned pigs (7.66±1.09 kg BW) were randomly assigned to 1 of 5 treatments, including a negative control diet without Zn supplementation, a positive control diet (2,250 mg/kg ZnO), and 3 experimental diets with different concentrations of TBZC supplemen tation (1,000, 1,250, and 1,500 mg/kg). Results: In Exp. 1, the average daily gain (ADG), feed efficiency (G:F) and diarrhea incidence responded quadratically (p<0.01) as the TBZC supplemental concentrations increased, and pigs fed 1,200 and 1,800 mg/kg TBZC showed the best growth performance. Moreover, 1,800 mg/kg TBZC supplementation showed the greatest (p<0.01) total antioxidant capacity and glutathione peroxidase activities in liver of pigs. Histopathological examination revealed lesions in heart, liver, lung and kidney, and mild or severe histological lesions mainly occurred with the supplementation of 2,400 and 3,000 mg/kg TBZC. In Exp. 2, 1,000 and 1,250 mg/kg TBZC supplementation in diets significantly (p<0.01) increased ADG and G:F of weaned pigs, reduced Zn excretion in feces, and had no effect on diarrheareducing compared to 2,250 mg/kg ZnO supplementation. Conclusion: The TBZC is a potential alternative to ZnO. The recommended concentration of TBZC in weaned pig diets is 1,000 to 1,250 mg/kg.

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Zinc Modulates Glutamine Metabolism in T Cells

Güzel,

Rink,

Fischer

2023

Molecular Nutrition Food Res

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ScopeZinc and glutamine are well known to be essential for the function and polarization of immune cells. TH17 cells are more frequently induced during zinc deficiency and cover their energy requirement mainly through glutaminolysis. A dysregulation of TH17 cells can contribute to the development of autoimmune diseases. Both inhibition of glutaminolysis and zinc supplementation suppress experimental autoimmune encephalomyelitis in mice. Therefore, the aim of this study is to investigate whether zinc modulates glutaminolysis in T cells.Methods and resultsCD3/CD28 stimulation and mixed lymphocytes culture are used as in vitro models for T cell activation. Then, the glutaminolysis is investigated on mRNA, protein, and functional level. Zinc deficiency and glutaminase (GLS) inhibition decrease immune responses in vitro. Furthermore, extracellular zinc and glutamine levels both modulate glutaminolysis by changing the expression of glutamine transporters and key enzymes. Intriguingly, zinc directly interferes with the activity of GLS both in a cell free system and in the cytosol.ConclusionBesides T cell subset differentiation, zinc also impacts on the cellular metabolism by inhibiting glutaminolysis. This suggests that zinc deficiency can contribute to the development of autoimmune diseases whereas zinc supplementation can support their therapy.

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Effects of Zinc on Interleukins and Antioxidant Enzyme Values in Psoriasis-Induced Mice

Cited by 18 publications

References 30 publications

Polyphenols as Potential Attenuators of Heat Stress in Poultry Production

Polyphenols as Potential Attenuators of Heat Stress in Poultry Production

Moderate tetrabasic zinc chloride supplementation improves growth performance and reduces diarrhea incidence in weaned pigs

Zinc Modulates Glutamine Metabolism in T Cells

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