Polyphenols as Potential Attenuators of Heat Stress in Poultry Production

Hu, Ruizhi; He, Yang; Arowolo, Muhammed Adebayo; Wu, Shusong; He, Jianhua

doi:10.3390/antiox8030067

Cited by 109 publications

(115 citation statements)

References 73 publications

(118 reference statements)

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“…The responses were also dose-dependent with the highest dose investigated being most efficacious. The positive effects of POL on regulating the expression of heat shock proteins [23] could help chickens to reduce their body temperature. Polyphenols are micronutrients with strong antioxidants properties and potential health benefits such as improving digestion issues and weight gain [24].…”

Section: Discussionmentioning

confidence: 99%

A Dietary Sugarcane-Derived Polyphenol Mix Reduces the Negative Effects of Cyclic Heat Exposure on Growth Performance, Blood Gas Status, and Meat Quality in Broiler Chickens

Shakeri

Cottrell

Wilkinson³

et al. 2020

Animals

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Heat stress (HS) compromises growth performance and meat quality of broiler chickens by interrupting lipid and protein metabolism, resulting in increased oxidative damages. The experiment attempted to investigate whether dietary polyphenols (Polygain (POL)) could ameliorate the aforementioned adverse effects of HS on performance and meat quality. One hundred and twenty one day-old-male chicks were allocated to two temperature conditions, thermoneutral (TN) or HS, and fed with either a control diet (CON) or the CON plus four different doses of POL (2, 4, 6 and 10 g/kg). Heat stress caused respiratory alkalosis as evidenced by increased rectal temperature (p < 0.001) and respiration rate (p < 0.001) due to increased blood pH (p < 0.001). Heat stress decreased final body weight (p = 0.061) and breast muscle water content (p = 0.013) while POL improved both (p = 0.002 and p = 0.003, respectively). Heat stress amplified muscle damages, indicated by increased thiobarbituric acid reactive substances (p < 0.001) and reduced myofibril fragmentation index (p = 0.006) whereas POL improved both (p = 0.037 and p = 0.092, respectively). Heat stress impaired meat tenderness (p < 0.001) while POL improved it (p = 0.003). In conclusion, HS impaired growth performance and meat quality whereas POL ameliorated these responses in a dose-dependent manner, and effects of POL were evident under both temperature conditions.

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Section: Discussionmentioning

confidence: 99%

A Dietary Sugarcane-Derived Polyphenol Mix Reduces the Negative Effects of Cyclic Heat Exposure on Growth Performance, Blood Gas Status, and Meat Quality in Broiler Chickens

Shakeri

Cottrell

Wilkinson³

et al. 2020

Animals

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“…Inadequate temperature [32][33][34][35][36][37][38][39] Inadequate ventilation and increased dust [1,18,19,40,41] Inadequate lightning [1,18,19,42,43]…”

Section: Technological Stressorsmentioning

confidence: 99%

Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update

et al. 2019

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Poultry in commercial settings are exposed to a range of stressors. A growing body of information clearly indicates that excess ROS/RNS production and oxidative stress are major detrimental consequences of the most common commercial stressors in poultry production. During evolution, antioxidant defence systems were developed in poultry to survive in an oxygenated atmosphere. They include a complex network of internally synthesised (e.g., antioxidant enzymes, (glutathione) GSH, (coenzyme Q) CoQ) and externally supplied (vitamin E, carotenoids, etc.) antioxidants. In fact, all antioxidants in the body work cooperatively as a team to maintain optimal redox balance in the cell/body. This balance is a key element in providing the necessary conditions for cell signalling, a vital process for regulation of the expression of various genes, stress adaptation and homeostasis maintenance in the body. Since ROS/RNS are considered to be important signalling molecules, their concentration is strictly regulated by the antioxidant defence network in conjunction with various transcription factors and vitagenes. In fact, activation of vitagenes via such transcription factors as Nrf2 leads to an additional synthesis of an array of protective molecules which can deal with increased ROS/RNS production. Therefore, it is a challenging task to develop a system of optimal antioxidant supplementation to help growing/productive birds maintain effective antioxidant defences and redox balance in the body. On the one hand, antioxidants, such as vitamin E, or minerals (e.g., Se, Mn, Cu and Zn) are a compulsory part of the commercial pre-mixes for poultry, and, in most cases, are adequate to meet the physiological requirements in these elements. On the other hand, due to the aforementioned commercially relevant stressors, there is a need for additional support for the antioxidant system in poultry. This new direction in improving antioxidant defences for poultry in stress conditions is related to an opportunity to activate a range of vitagenes (via Nrf2-related mechanisms: superoxide dismutase, SOD; heme oxygenase-1, HO-1; GSH and thioredoxin, or other mechanisms: Heat shock protein (HSP)/heat shock factor (HSP), sirtuins, etc.) to maximise internal AO protection and redox balance maintenance. Therefore, the development of vitagene-regulating nutritional supplements is on the agenda of many commercial companies worldwide.

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“…However, in our study down regulation of HSP70 expression level was achieved by each extracts (Pomo and Pistachio) by different percentages (Table 3, fig.9), but again pistachio extract in its nano form was the most powerful as an anti-inflammatory compared to pomegranate. This is may be interpreted upon the powerful flavonoids beside other phenolic compounds benzoic acid, and hydroxycinnamic acid derivatives, that have antioxidant properties exist in the nano pistachio to induce strong HSP70 immunoreactivity , prevent protein denaturation and succeeded to overcome TAA induced liver damage [91,92] .…”

Section: Discussionmentioning

confidence: 99%

The Conquering influence of the Nano extracts of pomegranate peels and pistachio leaves in amelioration of acute liver failure

Hassan¹,

Hammam

Awadallah³

et al. 2020

Preprint

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ObjectiveAcute liver failure (ALF) is a clinical condition with an unclear history of pathophysiology, making it a challenging task for scientists to reverse the disease in its initial phase and to help the liver re-function as usual: this study was proposed to estimate the hepatoprotective effects of Punicagranatum peel and Pistaciaatlantica leaves as a multi-rich antioxidants ingredients either in their normal and/or in their nano forms against thioacetamide induced acute liver failure in a rodent model.MethodSixty male Wistar rats were divided into six equal groups, the first group employed as a control; the second group was given a dose of thioacetamide (TAA)-350 mg/bwip., from the third to the sixth group received TAA □ 2ml of 100gm of aqueous extracts of PunicagranatumL and Pistaciaatlantica either in their normal and/or Nano forms consecutively along 2 weeks.Resultsrecorded significant elevation in liver enzymes, lipid profiles, LPO and NO with marked significant decrease in GSH and SOD accompanied by elevation in inflammatory cytokine (IL6,TNF-α and AFP) in addition to a noticeable increase in HSP70 level & degradation in DNA respectively in TAA challenged group. However significant and subsequent amelioration of most of the impaired markers has been observed with ipnano treatment of both extracts.ConclusionThe current results highlighted the high performance of both plant nano extracts and their hepatoprotective impact and their possible therapeutic role in the amelioration of TAA induced acute liver failure in experimental animals.

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Polyphenols as Potential Attenuators of Heat Stress in Poultry Production

Cited by 109 publications

References 73 publications

A Dietary Sugarcane-Derived Polyphenol Mix Reduces the Negative Effects of Cyclic Heat Exposure on Growth Performance, Blood Gas Status, and Meat Quality in Broiler Chickens

A Dietary Sugarcane-Derived Polyphenol Mix Reduces the Negative Effects of Cyclic Heat Exposure on Growth Performance, Blood Gas Status, and Meat Quality in Broiler Chickens

Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update

The Conquering influence of the Nano extracts of pomegranate peels and pistachio leaves in amelioration of acute liver failure

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