Effects of Yeast Mannan Which Promotes Beneficial Bacteroides on the Intestinal Environment and Skin Condition: A Randomized, Double-Blind, Placebo-Controlled Study

Tanihiro, Reiko; Sakano, Katsuhisa; Oba, Shunsuke; Nakamura, Chikako; Ohki, Kohji; Hirota, Toshiyuki; Sugiyama, Hiroshi; Ebihara, Shukuko; Nakamura, Yasunori

doi:10.3390/nu12123673

Cited by 19 publications

(17 citation statements)

References 46 publications

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“…Bacteroides was the only genera with average relative abundance higher than 5% that was modulated by MedDiet. Bacteroides includes potentially beneficial species that could promote mucosal colonization, enforce the epithelial barrier of the gut, and have anti-inflammatory properties [ 58 , 59 ]. All other modulated taxa had a relative abundance lower than 5%, an observation similar to what was reported after 7 days of antibiotics [ 28 ], which further supports the idea that many microbiota modulators affect lower abundance taxa.…”

Section: Discussionmentioning

confidence: 99%

The diet rapidly and differentially affects the gut microbiota and host lipid mediators in a healthy population

et al. 2023

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Background Bioactive lipids produced by human cells or by the gut microbiota might play an important role in health and disease. Dietary intakes are key determinants of the gut microbiota, its production of short-chain (SCFAs) and branched-chain fatty acids (BCFAs), and of the host endocannabinoidome signalling, which are all involved in metabolic diseases. This hypothesis-driven longitudinal fixed sequence nutritional study, realized in healthy participants, was designed to determine if a lead-in diet affects the host response to a short-term dietary intervention. Participants received a Mediterranean diet (MedDiet) for 3 days, a 13-day lead-in controlled diet reflecting the average Canadian dietary intake (CanDiet), and once again a MedDiet for 3 consecutive days. Fecal and blood samples were collected at the end of each dietary phase to evaluate alterations in gut microbiota composition and plasma levels of endocannabinoidome mediators, SCFAs, and BCFAs. Results We observed an immediate and reversible modulation of plasma endocannabinoidome mediators, BCFAs, and some SCFAs in response to both diets. BCFAs were more strongly reduced by the MedDiet when the latter was preceded by the lead-in CanDiet. The gut microbiota response was also immediate, but not all changes due to the CanDiet were reversible following a short dietary MedDiet intervention. Higher initial microbiome diversity was associated with reduced microbiota modulation after short-term dietary interventions. We also observed that BCFAs and 2-monoacylglycerols had many, but distinct, correlations with gut microbiota composition. Several taxa modulated by dietary intervention were previously associated to metabolic disorders, warranting the need to control for recent diet in observational association studies. Conclusions Our results indicate that lipid mediators involved in the communication between the gut microbiota and host metabolism exhibit a rapid response to dietary changes, which is also the case for some, but not all, microbiome taxa. The lead-in diet influenced the gut microbiome and BCFA, but not the endocannabinoidome, response to the MedDiet. A higher initial microbiome diversity favored the stability of the gut microbiota in response to dietary changes. This study highlights the importance of considering the previous diet in studies relating the gut microbiome with lipid signals involved in host metabolism.

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Section: Discussionmentioning

confidence: 99%

The diet rapidly and differentially affects the gut microbiota and host lipid mediators in a healthy population

et al. 2023

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“…Mannan polysaccharides, recognized as innate immune stimulants, bolster both non-specific and targeted immune responses [ 33 ]. Documented to exhibit potent antiviral immunity [ 34 ], they can also decrease gastrointestinal tryptophan and serotonin levels, improving the gut environment [ 35 ]. Thus, the efficacy of SJP in mitigating alcoholic hepatic impairments in zebrafish larvae seems inferior to LJP.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Jiuzao polysaccharides in ameliorating alcoholic fatty liver disease and modulating gut microbiota

Li,

Pei,

Chen

et al. 2024

Heliyon

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“…The clinical application of prebiotics has received increasing attention because of their low risk of serious side effects, ease of administration, and high potential to influence the composition and function of intestinal microbiota. We previously found that yeast mannan (YM) promotes the growth of specific Bacteroides in both in vitro and in vivo studies [ 7 , 8 , 9 ]. YM is a soluble, indigestible carbohydrate originating from the yeast cell walls and consists of highly branched mannose polymers with molecular weights ranging from 20 to 200 kDa [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Prebiotic Yeast Mannan on Gut Health and Sleep Quality in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study

Tanihiro,

Yuki,

Sasai

et al. 2023

Nutrients

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Human gut health is closely related to sleep. We aimed to evaluate the efficacy of yeast mannan (YM) in improving bowel habits and sleep quality, along with metabolomics in fecal samples. A total of 40 healthy adults (age range, 22–64 years) with discomfort in defecation were enrolled and randomly allocated to receive either YM (n = 20; 1.1 g/day) or placebo (n = 20) for four weeks. Participants recorded their defecation habits throughout the test periods. Sleep electroencephalogram (EEG) recording using an EEG device and fecal sampling were performed pre- and post-treatment. The YM group significantly increased defecation frequency and stool volumes compared to the placebo group. After 4 weeks of treatment, the non-REM sleep stage 3 (N3) duration in the YM group was significantly higher than that in the placebo group. YM ingestion significantly lengthened total time in bed (TIB) and significantly shortened N3 latency compared to placebo intake during the trial. The metabolomics analysis found a total of 20 metabolite differences between the YM and placebo groups. As a result of stepwise linear regression, changes in fecal propionate and gamma-aminobutyric acid (GABA) levels were identified as the primary factors explaining changes in TIB and N3 latency, respectively. Our findings suggest that the prebiotic YM could be beneficial to gut health and sleep quality.

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Effects of Yeast Mannan Which Promotes Beneficial Bacteroides on the Intestinal Environment and Skin Condition: A Randomized, Double-Blind, Placebo-Controlled Study

Cited by 19 publications

References 46 publications

The diet rapidly and differentially affects the gut microbiota and host lipid mediators in a healthy population

The diet rapidly and differentially affects the gut microbiota and host lipid mediators in a healthy population

Efficacy of Jiuzao polysaccharides in ameliorating alcoholic fatty liver disease and modulating gut microbiota

Effects of Prebiotic Yeast Mannan on Gut Health and Sleep Quality in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study

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