Effects of whole-body vibration and high impact exercises on the bone metabolism and functional mobility in postmenopausal women

Şen, Ekin İlke; Esmaeilzadeh, Sina; Eskiyurt, Nurten

doi:10.1007/s00774-019-01072-2

Cited by 39 publications

(51 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The present work focused on investigating participants with the precursor conditions MGUS and smoldering myeloma to avoid a potential MM treatment-associated bias and to reduce the risk of intervention-related adverse events. WBV as intervention was selected for this type of patients because i) available data confirms this type of exercise to be safe [33] , ii) WBV is time efficient, iii) WBV allows employing established principles of exercise intervention in untrained elderly patients [27] and iv) evidence reveals that WBV vibration is a potent stimulus to induce favorable changes in bone metabolism and architecture [43] . There is clear evidence that exercise intervention and specifically WBV elicit improvements in neuro-muscular performance [35] , [41] .…”

Section: Discussionmentioning

confidence: 99%

“…More recently, favorable effects of WBV on quality of life, physical functioning, and fatigue were evidenced in patients with hematological malignancies [41] , [42] . Beyond the well-established neuromuscular adaption, further evidence implies positive responses of WBV on bone metabolism and bone mineral density in patients with osteoporosis [43] , [44] . Whether these alterations of bone structure and metabolism in osteoporotic patients are mainly caused by enhanced muscular function or rather a direct vibration-induced bone response through e.g.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of whole-body vibration exercise on physical performance and bone turnover in patients with monoclonal gammopathy of undetermined significance

Seefried

Genest

Strömsdörfer

et al. 2020

Journal of Bone Oncology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of whole-body vibration exercise on physical performance and bone turnover in patients with monoclonal gammopathy of undetermined significance

Seefried

Genest

Strömsdörfer

et al. 2020

Journal of Bone Oncology

View full text Add to dashboard Cite

show abstract

“…A randomized controlled trial shows that the bone mineral density of femoral neck and lumbar spine in postmenopausal women upon 6-month whole- body vibration are more than in the control group. The serum osteocalcin levels rather than C-telopeptide of type I collagen levels are decreased in the whole-body vibration intervention group [ 45 ].…”

Section: Biophysical Stimulation Intervention For Promoting Bone Integritymentioning

confidence: 99%

Biophysical Modulation of the Mitochondrial Metabolism and Redox in Bone Homeostasis and Osteoporosis: How Biophysics Converts into Bioenergetics

Wang

Chen

et al. 2021

Antioxidants

View full text Add to dashboard Cite

Bone-forming cells build mineralized microstructure and couple with bone-resorbing cells, harmonizing bone mineral acquisition, and remodeling to maintain bone mass homeostasis. Mitochondrial glycolysis and oxidative phosphorylation pathways together with ROS generation meet the energy requirement for bone-forming cell growth and differentiation, respectively. Moderate mechanical stimulations, such as weight loading, physical activity, ultrasound, vibration, and electromagnetic field stimulation, etc., are advantageous to bone-forming cell activity, promoting bone anabolism to compromise osteoporosis development. A plethora of molecules, including ion channels, integrins, focal adhesion kinases, and myokines, are mechanosensitive and transduce mechanical stimuli into intercellular signaling, regulating growth, mineralized extracellular matrix biosynthesis, and resorption. Mechanical stimulation changes mitochondrial respiration, biogenesis, dynamics, calcium influx, and redox, whereas mechanical disuse induces mitochondrial dysfunction and oxidative stress, which aggravates bone-forming cell apoptosis, senescence, and dysfunction. The control of the mitochondrial biogenesis activator PGC-1α by NAD+-dependent deacetylase sirtuins or myokine FNDC/irisin or repression of oxidative stress by mitochondrial antioxidant Nrf2 modulates the biophysical stimulation for the promotion of bone integrity. This review sheds light onto the roles of mechanosensitive signaling, mitochondrial dynamics, and antioxidants in mediating the anabolic effects of biophysical stimulation to bone tissue and highlights the remedial potential of mitochondrial biogenesis regulators for osteoporosis.

show abstract

“…Whole-body vibration (WBV) alone or in combination with multi-component exercise programs of strength, aerobic, high impact, and/or weight-bearing training, as well as whole-body vibration (WBV) alone or in combination with exercise protocol, may help to improve functional mobility, QoL, and depressive symptoms in post-menopausal women, adults, and older populations. (Gomez-Cabello et al, 2012;Bolam et al, 2013;Sen et al, 2020). According to (Jepsen et al, 2019), adding WBV to teriparatide resulted in a significant increase in BMD in the lumbar spine at 12 months, as well as indices of bone turnover after 3 and 6 months.…”

Section: Effect Of Exercise and Wbvmentioning

confidence: 99%

Long-term effect of full-body pulsed electromagnetic field and exercise protocol in the treatment of men with osteopenia or osteoporosis: A randomized placebo-controlled trial

et al. 2021

View full text Add to dashboard Cite

Background: Osteoporosis is the most prevalent metabolic disease affecting bones. Objective: To investigate the long-term effect of pulsed electromagnetic field (PEMF) combined with exercise protocol on bone mineral density (BMD) and bone markers in men with osteopenia or osteoporosis. Methods: Ninety-five males with osteopenia or osteoporosis (mean age, 51.26 ± 2.41 years; mean height, 176 ± 2.02 cm; mean weight, 83.08 ± 2.60 kg; mean body–mass index (BMI), 26.08 ± 1.09 kg/m2) participated in the study, and they were randomly assigned to one of three groups: Group 1 received a full-body PEMF and exercise protocol (PEMF +EX), Group 2 received a placebo full-body PEMF and exercise protocol (PPEMF +EX), and Group 3 received a full-body PEMF alone (PEMF). PEMF was applied for the whole body using a full-body mat three times per week for 12 weeks, with an exercise protocol that includes flexibility, aerobic exercise, strengthening, weight-bearing, and balance exercises followed by whole-body vibration (WBV) training. Outcome measures include BMD of total hip and lumbar spine and bone markers [serum osteocalcin (s-OC), Serum amino-terminal cross-linking telopeptide of type I collagen (s-NTX), Serum carboxy-terminal cross-linking telopeptide of type I collagen (s-CTX), Parathyroid hormones (PTH), Bone-specific Alkaline Phosphatase (BSAP), and 25-hydroxy vitamin D (Vit D)]. Results: The BMD of total hip and lumbar spine was significantly increased post-treatment in all groups, and more so in Group 1 and Group 2 than Group 3. There was a significant difference in bone markers in all groups, more so in Group 1 and Group 2 than in Group 3. Conclusion: PEMF combined with exercise protocol exerts a potent role for treating OP, is more effective than exercise and PEMF alone for increasing BMD and enhancing bone formation, and suppresses bone-resorption markers after 12-weeks of treatment with the impact lasting up to 6 months.

show abstract

Effects of whole-body vibration and high impact exercises on the bone metabolism and functional mobility in postmenopausal women

Cited by 39 publications

References 41 publications

Impact of whole-body vibration exercise on physical performance and bone turnover in patients with monoclonal gammopathy of undetermined significance

Impact of whole-body vibration exercise on physical performance and bone turnover in patients with monoclonal gammopathy of undetermined significance

Biophysical Modulation of the Mitochondrial Metabolism and Redox in Bone Homeostasis and Osteoporosis: How Biophysics Converts into Bioenergetics

Long-term effect of full-body pulsed electromagnetic field and exercise protocol in the treatment of men with osteopenia or osteoporosis: A randomized placebo-controlled trial

Contact Info

Product

Resources

About