Impact of whole-body vibration exercise on physical performance and bone turnover in patients with monoclonal gammopathy of undetermined significance

Seefried, Lothar; Genest, Franca; Strömsdörfer, Johanna; Engelmann, Bernhard; Lapa, Constantin; Jakob, Franz; Baumann, Freerk T.; Sperlich, Billy; Jundt, Franziska

doi:10.1016/j.jbo.2020.100323

Cited by 7 publications

(17 citation statements)

References 60 publications

(74 reference statements)

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“…In clinical settings, exercise training has already been proven to be feasible in patients suffering from MM [ 32 , 33 ]. We recently showed that whole-body vibration exercise benefits physical fitness and bone turnover in patients with monoclonal gammopathy of undetermined significance, a precursor condition of MMBD [ 29 ]. Based on our previous findings and the reports by Eda et al that a combination treatment of CC-292 with carfilzomib improved bone mass [ 10 ], we further reasoned that the combination of mechanical loading with CC-292 enhances the osteoprotective effect of physical stimuli.…”

Section: Discussionmentioning

confidence: 99%

“…Physical stimuli have a potent non-pharmacological anabolic effect as exercise enhances bone mass in the elderly [ 27 , 28 ]. Recently, we showed in a clinical study that whole-body vibration exercise is beneficial with respect to physical performance in patients with monoclonal gammopathy of undetermined significance, a precursor condition of MMBD [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

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Prevention of Bone Destruction by Mechanical Loading Is Not Enhanced by the Bruton’s Tyrosine Kinase Inhibitor CC-292 in Myeloma Bone Disease

Ziouti

Rummler

Steyn

et al. 2021

IJMS

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Limiting bone resorption and regenerating bone tissue are treatment goals in myeloma bone disease (MMBD). Physical stimuli such as mechanical loading prevent bone destruction and enhance bone mass in the MOPC315.BM.Luc model of MMBD. It is unknown whether treatment with the Bruton’s tyrosine kinase inhibitor CC-292 (Spebrutinib), which regulates osteoclast differentiation and function, augments the anabolic effect of mechanical loading. CC-292 was administered alone and in combination with axial compressive tibial loading in the MOPC315.BM.Luc model for three weeks. However, neither CC-292 alone nor its use in combination with mechanical loading was more effective in reducing osteolytic bone disease or rescuing bone mass than mechanical stimuli alone, as evidenced by microCT and histomorphometric analysis. Further studies are needed to investigate novel anti-myeloma and anti-resorptive strategies in combination with physical stimuli to improve treatment of MMBD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevention of Bone Destruction by Mechanical Loading Is Not Enhanced by the Bruton’s Tyrosine Kinase Inhibitor CC-292 in Myeloma Bone Disease

Ziouti

Rummler

Steyn

et al. 2021

IJMS

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“…Vibration 2023, 6, FOR PEER REVIEW 3 In this review paper, we will summarize vibration studies involving cancer models (Figure 1) in clinical trials (Table 1) [51][52][53][54][55][56], in animal studies (Table 2) [57][58][59], and in vitro studies examining bone-cancer cell interactions (Table 3) [16,17,60]. We will also discuss various parameters that may affect vibration efficacy, including age, vibration settings, and differences between bone sites.…”

Section: Mechanical Stimulation and Specifically Vibrationmentioning

confidence: 99%

“…The effects of vibration on cancer patients (Table 1) [51][52][53][54][55][56], cancer animal models (Table 2) [57][58][59], and bone-cancer cell interactions (Table 3) [16,17,60] are summarized below (Figure 1). Specifically, we examine vibration safety, summarize vibration effects on bone health (i.e., BMD, bone volume, bone remodeling, and bone turnovers), and elucidate the impacts of vibration on tumor burden and progression, bone vascularization, and mesenchymal stem cells (MSCs).…”

Section: Vibration Effects On Cancer Models and Bone-cancer Cell Inte...mentioning

confidence: 99%

Vibration Therapy for Cancer-Related Bone Diseases

et al. 2023

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Patients undergoing cancer treatments and/or suffering from metastatic bone lesions experience various skeletal-related events (SREs), substantially reducing functional independence and quality of life. Therefore, researchers are working towards developing new interventions by harnessing the bone’s innate anabolic response to mechanical stimulations. Whole body vibration (WBV) has recently gained interest due to its nature of being safe, effective, and easy to perform. In this review, we will summarize the most cutting-edge vibration studies of cancer models and bone-cancer cell interactions. We will also discuss various parameters, including age, vibration settings, and differences between bone sites, which may affect vibration efficacy. Studies have shown that WBV improves bone mineral density (BMD) and bone volume in patients and mice with cancer. WBV also reduces tumor burden and normalizes bone vasculature in mice. At the cellular level, vibration promotes interactions between bone cells and cancer cells, which reduce osteoclastogenesis and inhibit cancer metastatic potential. Hence, WBV could potentially serve as a new intervention or adjuvant treatment to attenuate cancer progression while preserving bone health.

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“…Most importantly, accounting for the small sample size of eight patients and the heterogeneous exercise participation and measurement procedure, either a large effect size or factors of chance and positive selection bias led to statistical significance. Recently, we demonstrated a highly significant improvement of physical activity and functioning in patients with the precursor condition monoclonal gammopathy of undetermined significance under whole-body vibration exercise training [28].…”

Section: Adherence and Efficacymentioning

confidence: 99%

Clinical exercise therapy program with multiple myeloma patients: Impacts on feasibility, adherence and efficacy

Wefelnberg

Niels

Jundt

et al. 2022

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Purpose Multiple myeloma (MM) is a severe hemato-oncological disease with high mortality and increasing incidence rate. Since evidence on exercise therapy in MM patients remains limited, this study examines feasibility, adherence, and efficacy based on real-life data from an oncologic care structure. Methods A data evaluation of MM patients who participated in the oncologic exercise and movement therapy (OTT) at the Cologne University Hospital between 2012 and 2019 was conducted. The patient flow was incrementally reduced to four cohorts, intention-to-treat cohort (ITTC), safety cohort (SC), adherence cohort (AC), and efficacy cohort (EC). Cohorts were evaluated descriptively and by means of correlation analysis as well as group and time comparisons. Results Thirty patients registered at the OTT between 2012 and 2019 (ITTC). The SC (N = 26) attended exercise therapy on average about one session per week over a period of 8 months. One-third dropped out within 3 months. In the AC (N = 15), BMI at baseline exhibited a strong and very significant negative correlation with exercise adherence. In the EC (N = 8), a significant improvement in physical functioning and a tendency towards significance in fatigue reduction between two measurement points was observed. No adverse events were documented. Conclusions The present observatory study reveals safety and feasibility while indicating adherence and efficacy of exercising MM patients under real-life therapy circumstances. Found obstacles to exercising as well as improvements in questionnaire scale scores need to be further examined in confirmatory study designs.

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Impact of whole-body vibration exercise on physical performance and bone turnover in patients with monoclonal gammopathy of undetermined significance

Cited by 7 publications

References 60 publications

Prevention of Bone Destruction by Mechanical Loading Is Not Enhanced by the Bruton’s Tyrosine Kinase Inhibitor CC-292 in Myeloma Bone Disease

Prevention of Bone Destruction by Mechanical Loading Is Not Enhanced by the Bruton’s Tyrosine Kinase Inhibitor CC-292 in Myeloma Bone Disease

Vibration Therapy for Cancer-Related Bone Diseases

Clinical exercise therapy program with multiple myeloma patients: Impacts on feasibility, adherence and efficacy

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