Effects of Water Extracts of Red Pepper Seeds Powder on Antioxidative Enzyme Activities and Oxidative Damage in Rats Fed High-Fat and High-Cholesterol Diets

Kim, Yu Na; Ku, Kyung Hyung; Kang, Sin Kwon; Choi, Jeong-Hwa

doi:10.4163/kjn.2011.44.4.284

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…항산화 물질은 생체 내에서 생성되는 활성산소 및 이에 의해 유도되는 지질과산화 반응을 억제하며 고혈압, 협심증, 당뇨병과 같은 성인병을 예방해 주며 나아가 발암 및 노화를 억제하는 생리활성 물질로서 크게 각광을 받고 있다 [17]. 또한 최근 암 예방(chemoprevention)을 위한 물질의 항 산화 효과에 대한 실험들이 방대하게 이루어지고 있다 [4].…”

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Effect of Polygala radix Hot Water Extract on Biological Activity in PC12 Cells

Nam¹,

Kim²

2013

Journal of Life Science

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The root of Polygala radix has been widely known as an oriental traditional medicinal stuff that improves memory. However, its mechanism of action remains unclear. In this study, the effect of Polygala radix hot water extracts (PRHWE) on cognitive function related to the activity of acetylcholinesterase (AchE) derived from neural cells (PC12) in addition to antioxidant activity was examined both in a cell-free system and live cells. First, in the study on cell viability using an MTT assay, PRHWE did not exhibit any cell toxicity at 0.1% (w/v) or below. It also was observed that PRHWE increased the scavenging activity of DPPH radical, hydrogen peroxide and superoxide, reducing power in a dose-dependent manner. In particular, PRHWE had a protective effect on DNA oxidation induced by hydroxyl radicals. Additionally, it inhibited the production of inducible nitric oxide in neuronal cells. Furthermore, the AchE activity decreased with increasing concentrations. In addition, PRHWE increased the expression level of SOD-1 and NOS-2 in PC12 cells. Moreover, the transcriptional activities of p53 and NF-ĸB were reduced in the presence of PRHWE in an experiment using a reporter gene assay. Therefore, these results prove that PRHE has antioxidative and protective effects on neuronal cells, suggesting that it may have great potential as a therapeutic agent for human health.

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Effect of Polygala radix Hot Water Extract on Biological Activity in PC12 Cells

Nam¹,

Kim²

2013

Journal of Life Science

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Korean Traditional Natural Herbs and Plants as Immune Enhancing, Antidiabetic, Chemopreventive, and Antioxidative Agents: A Narrative Review and Perspective

Park

Kim

2014

Journal of Medicinal Food

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The world is becoming increasingly interested in Korean food and its ingredients. The attention goes beyond the typical examples, such as kimchi and fermented sauces; peculiar food ingredients that are widely consumed in Korea are now entering the world's functional food markets. This trend was supported by scientific research, and this review seeks to combine and summarize the findings of the past 10 years. The results are organized into four groups depending on whether the ingredient strengthens the immune system, has antidiabetic effects, has chemopreventive effects, or has an antioxidative effects. We would also like to point out that this review only covers the topic of Korean traditional plants and herbs. After the summary of research findings, we discuss challenges and opportunities, exploring the direction of future research and the potential of Korean traditional food ingredients in food industry and markets.

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