Effects of voluntary wheel running on heart rate, body temperature, and locomotor activity in response to acute and repeated stressor exposures in rats

Masini, Cher V.; Nyhuis, Tara J.; Sasse, Sarah K.; Day, Heidi E.W.; Campeau, Serge

doi:10.3109/10253890.2010.548013

Cited by 17 publications

(35 citation statements)

References 64 publications

(95 reference statements)

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“…All rats were tested under all 5 priming conditions in nonsystematic order, with the exception that the yohimbine alone priming condition always came first. It was hypothesized that there may be a possible carry-forward effect of chronic W during extinction on yohimbine-primed cocaine seeking during later reinstatement tests, since prior research supported a role for exercise in reducing physiological responses to stress (Sasse et al 2008, Masini et al 2011). Nonsystematic treatment sequences within the 5 different priming condition blocks (“X”; e.g., yohimbine alone, yohimbine + cocaine-paired stimuli, cocaine alone, cocaine + cocaine-paired stimuli, and cocaine-paired stimuli alone) were as follows: LW+X, W+X, LW+P+X, W+P+X.…”

Section: Methodsmentioning

confidence: 99%

Effects of combined exercise and progesterone treatments on cocaine seeking in male and female rats

2014

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BACKGROUND Individually, both treatment with progesterone and concurrent access to an exercise wheel reduce cocaine self-administration under long-access conditions and suppress cocaine-primed reinstatement in female rats. In the present study, wheel running and progesterone (alone and combined) were assessed for their effects on reinstatement of cocaine-seeking primed by yohimbine, cocaine, and cocaine-paired cues. METHODS Male and female rats were implanted with an intravenous catheter and allowed to self-administer cocaine (0.4 mg/kg/inf, iv) during 6-h sessions for 10 days. Subsequently, the groups of male and female rats were each divided into 2 groups that were given concurrent access to either a locked or unlocked running wheel under extinction conditions for 14 days. Next, all 4 groups were tested in a within-subjects design for reinstatement of cocaine-seeking precipitated by separate administration of cocaine-paired stimuli, yohimbine, or cocaine; or the combination of yohimbine + cocaine-paired stimuli or cocaine + cocaine-paired stimuli. These priming conditions were tested in the presence of concurrent wheel access (W), pretreatment with progesterone (P), or both (W+P). RESULTS In agreement with previous results, females responded more for cocaine than males during maintenance. Additionally, concurrent wheel running attenuated extinction responding and cocaine-primed reinstatement in females but not males. Across all priming conditions, W+P reduced reinstatement compared to control conditions, and for cocaine-primed reinstatement in male rats, the combined W+P treatment was more effective than W or P alone. CONCLUSION Under certain conditions, combined behavioral (exercise) and pharmacological (progesterone) interventions were more successful at reducing cocaine-seeking behavior than either intervention alone.

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Section: Methodsmentioning

confidence: 99%

Effects of combined exercise and progesterone treatments on cocaine seeking in male and female rats

2014

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“…However, several reports measured the influence of wheel running on evoked responding in tests of anxiety by exposing rodents to a stressor (Dishman et al, 1997; Fox et al, 2008; Greenwood et al, 2005a, 2003a, 2008, 2007; Lancel et al, 2003; Masini et al, 2011; Salam et al, 2009; Sciolino et al, 2012) or stress-based models of anxiety (De Chiara et al, 2010; Maniam and Morris, 2010; Zheng et al, 2006). Based on evidence available to date, we propose that the behavioral efficacy of exercise in tests of anxiety is influenced by stress, including stress-based models of anxiety.…”

Section: Tests and Models Of Anxiety In Rodentsmentioning

confidence: 99%

“…It is important to note that benefit of exercise on evoked responding in an array of tests of anxiety is mainly due to stress-induced impairment in sedentary, but not exercise rodents (De Chiara et al, 2010; Dishman et al, 1997; Fox et al, 2008; Greenwood et al, 2005a, 2003a, 2008, 2007; Maniam and Morris, 2010; Masini et al, 2011; Sciolino et al, 2012; Zheng et al, 2006). Reliable detection of the beneficial consequences of wheel running may result only when stress is experimentally manipulated because the effects of exercise interact with stress to alter responding in a manner that behavioral screens can detect.…”

Section: Effects Of Wheel Running On Anxiety-like Behavior and Feamentioning

confidence: 99%

“…Novelty is speculated to provoke fear in rodents as measured by reduced exploration and enhanced avoidance in tests that evoke an approach-avoidance conflict (Blanchard et al, 1974; Montgomery, 1955; Montgomery and Monkman, 1955). Several reports suggest that wheel running minimizes the effects of novelty on spontaneous behavior (Collins et al, 2009; Droste et al, 2007; Garcia-Mesa et al, 2011; Masini et al, 2011). During exposure to a small novel cage or container, exercised rats exhibit more resting (i.e., more lying and/or stationary behaviors) and less non-resting behaviors (i.e., rearing, walking, grooming), all of which are displayed in an undisturbed rodent during the daytime (Collins et al, 2009; Droste et al, 2007; Garcia-Mesa et al, 2011; Masini et al, 2011).…”

Section: Effects Of Wheel Running On Anxiety-like Behavior and Feamentioning

confidence: 99%

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Exercise offers anxiolytic potential: A role for stress and brain noradrenergic-galaninergic mechanisms

Sciolino

Holmes

2012

Neuroscience & Biobehavioral Reviews

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Although physical activity reduces anxiety in humans, the neural basis for this response is unclear. Rodent models are essential to understand the mechanisms that underlie the benefits of exercise. However, it is controversial whether exercise exerts anxiolytic-like potential in rodents. Evidence is reviewed to evaluate the effects of wheel running, an experimental mode of exercise in rodents, on behavior in tests of anxiety and on norepinephrine and galanin systems in neural circuits that regulate stress. Stress is proposed to account for mixed behavioral findings in this literature. Indeed, running promotes an adaptive response to stress and alters anxiety-like behaviors in a manner dependent on stress. Running amplifies galanin expression in noradrenergic locus coeruleus (LC) and suppresses stress-induced activity of the LC and norepinephrine output in LC-target regions. Thus, enhanced galanin-mediated suppression of brain norepinephrine in runners is supported by current literature as a mechanism that may contribute to the stress-protective effects of exercise. These data support the use of rodents to study the emotional and neurobiological consequences of exercise.

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“…Moderate and regular exercise has attenuated aging-associated mitochondrial dysfunction (40), improved cognitive performance (41) and memory (42) and positively affected emotional aspects of behavior, resulting in better responses to acute or chronic stressor exposures (43).It was shown that exercise training in rats improved cardiac function following myocardial infarction (44), attenuated endotoxemia-induced lung damage (45) and reduced the progression of renal disease (46). In accordance with these, swimming exercise ameliorated RVH-induced oxidative damage of the kidneys via the inhibition of neutrophil infiltration.…”

Section: Discussionmentioning

confidence: 99%

Regular swimming exercise performed either before or after the induction of renovascular hypertension alleviates oxidative renal injury in rats

Kumral¹

2014

mpj

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Epidemiological studies have shown that regular exercise and increased aerobic fitness are associated with a decrease in allcause mortality and morbidity, including diseases related with high blood pressure. However, whether exercise has an antiinflammatory impact on the pathogenesis of hypertension was not elucidated yet. In the present study, to investigate the potential protective and therapeutic effects of exercise training (swimming for 30 min/day, 5 days/week for 9 weeks) on renovascular hypertension (RVH) 10-week-old male Wistar albino rats were divided into 4 groups as sham-operated sedentary control group, sedentary group with RVH (2-Kidney, 1-Clip Goldblatt) and two exercised RVH groups, which had 9-week training either before the surgery or after the surgery. Systolic blood pressures (SBP) were measured by the tail-cuff method on a weekly basis and at the end of 12 weeks, rats were decapitated to obtain kidneys. SBP were significantly higher in the sedentary RVH group than the control group, whereas in the trained RVH group measurements were not different than those of the control animals. In the renal tissues of the sedentary RVH group, malondialdehyde and myeloperoxidase levels were increased with a concomitant decrease in glutathione levels, while in the trained RVH group the levels were not different than those of the control group. Moreover, in the trained RVH group, superoxide dismutase and catalase levels measured as antioxidant parameters, were also significantly increased as compared with those of the sedentary RVH group. Current results demonstrate that regular moderate training controls high blood pressure in RVH, while RVH-induced oxidative damage in renal tissue is ameliorated through the modulation of oxidant-antioxidant balance. Exercise training does not only improve the circulatory functions, but it also initiates an anti-inflammatory process to defend against the angiotensin-II-induced renal injury.

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Effects of voluntary wheel running on heart rate, body temperature, and locomotor activity in response to acute and repeated stressor exposures in rats

Cited by 17 publications

References 64 publications

Effects of combined exercise and progesterone treatments on cocaine seeking in male and female rats

Effects of combined exercise and progesterone treatments on cocaine seeking in male and female rats

Exercise offers anxiolytic potential: A role for stress and brain noradrenergic-galaninergic mechanisms

Regular swimming exercise performed either before or after the induction of renovascular hypertension alleviates oxidative renal injury in rats

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