Effects of vitamins C and D in type 2 diabetes mellitus

Christie-David, Darshika; Girgis, Christian M.; Gunton, Jenny E.

doi:10.2147/nds.s52022

Cited by 19 publications

(20 citation statements)

References 75 publications

(79 reference statements)

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“…Although we had lost few patients to follow up, we were able to achieve a target sample size throughout the course of the study. The significant reduction in fasting blood glucose levels (Table 2) agrees with the report published by Girgis C et al 2015 [7]. Similarly Kostisawat J et al had reported that Vitamin C might help in reduction of glycated haemoglobin levels in Diabetes patients [8].…”

Section: Discussionsupporting

confidence: 87%

Effects of Vitamin C supplementation on the glycemic control and cardiovascular risk in type II Diabetes Mellitus

Praveen¹,

Puvvada²,

M³

2020

jrp

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The oral hypoglycaemic agents as well as injectable insulin does not significantly alter the oxidative stress in the diabetes mellitus patients. Being an antioxidant Vitamin C (ascorbic acid) might help in tackling the adversities of reactive oxygen species. A randomized placebo controlled study was carried out with parallel assignment of both the test group and control group of patients. The intervention model included metformin 500mg twice daily and a placebo once daily for control group. Alternatively, Vitamin C chewable tablets were given for the other group along with metformin 500mg twice daily. Our study postulates that there is a significant reduction in the fasting blood glucose, glycosylated haemoglobin levels, troponin T levels and Framingham risk score in participants who received ascorbic acid supplementation along with regular metformin. The supplementation of Vitamin C along with Metformin was well tolerated and did not cause any serious adverse drug reactions. The cheaper cost adjuvant approach with Vitamin C may be beneficial in patients in reducing the cardiovascular risk as well as to maintain an appropriate glycaemic control

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Section: Discussionsupporting

confidence: 87%

Effects of Vitamin C supplementation on the glycemic control and cardiovascular risk in type II Diabetes Mellitus

Praveen¹,

Puvvada²,

M³

2020

jrp

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“…Little is known about the effects of vitamin C in prediabetes, especially because controlled DM2-prevention studies using vitamin C are still needed 32 . In the present study, both groups given vitamin C had significantly lower fasting glycemia than the control group, demonstrating a glycemia-lowering effect of the vitamin.…”

Section: Discussionmentioning

confidence: 99%

Vitamin C decreases the obesogenic and hyperglycemic effect of invert sugar in prediabetic rats

Molz¹,

Rael

Fischer

et al. 2017

Rev. Nutr.

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Objective: To evaluate whether vitamin C can help to prevent obesity and hyperglycemia in Wistar rats treated with excess invert sugar to induce prediabetes. Methods: One hundred-day-old Male Wistar rats with a mean weight of 336.58±23.43g were randomly assigned to the following groups: (1) control, receiving water (C); (2) invert sugar control, receiving a 32% watery solution of invert sugar; (3) vitamin C control, receiving a watery solution of vitamin C (60mg/L), and (4) vitamin C plus invert sugar, receiving a watery solution of vitamin C and invert sugar. All animals had access to chow and water ad libitum and were treated for 17 weeks. Prediabetes was assessed according to two criteria: obesity (based on body mass indexand peritoneal fat content) and impaired glucose tolerance (assessed by the intraperitoneal glucose tolerance test and expressed as area under the curve) . Results: Group invert sugar control gained significantly more weight (p=0.035) and visceral fat (p<0.001) than groups vitamin C control and vitamin C plus invert sugar. Consequently, groups vitamin C control and vitamin C plus invert sugar had gained as little body mass index as group C by the end of the experiment. Vitamin C decreased the fasting glycemia of both groups supplemented with vitamin C and normalized the glucose tolerance of group vitamin C plus invert sugar, whose area under the curve matched that of group C. Conclusion: Vitamin C has anti-obesogenic and glycemia-lowering effects in Wistar rats, which might be promising to prediabetics. Future studies are needed to understand the anti-obesogenic and anti-hyperglycemic mechanisms of vitamin C in prediabetes.

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“…The antioxidant properties of vitamin C have been suggested as a plausible mechanism for the reduced risk of T2DM with high vitamin C intakes or plasma concentrations (6,7) . However, a review of observational studies indicated that these associations were evident in some but not in all previous studies (8) . Moreover, no association was reported in a large randomised controlled trial (9) .…”

mentioning

confidence: 92%

Among the water-soluble vitamins, dietary intakes of vitamins C, B₂and folate are associated with the reduced risk of diabetes in Japanese women but not men

et al. 2019

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Recent studies have shown that micronutrients are involved in the pathology of type 2 diabetes. Antioxidant effects of vitamins C and B2 and homocysteine-lowering effects of vitamins B6, folate and B12 may have protective roles. However, a few reports have investigated the association between dietary water-soluble vitamin intakes and risk of diabetes. In a prospective study encompassing 19 168 healthy Japanese men and women aged 40–79 years, we examined the associations between dietary intakes of water-soluble vitamins, determined by a validated self-administered FFQ, with the risk of 5-year cumulative incidence of type 2 diabetes by using the logistic regression model. Within the 5-year period, there were 494 self-reported new cases of diabetes. Higher dietary intakes of vitamins C, B2 and folate were associated with lower risk of incident diabetes only in women, whereas no associations of dietary intakes of vitamins B1, B3, B5, B6 and B12 were observed in either sex. The multivariable OR in the highest v. the lowest quartile of intakes among women were 0·61 (95 % CI 0·44, 0·94; P-trend = 0·04) for vitamin C, 0·56 (95 % CI 0·34, 0·93; P-trend = 0·03) for vitamin B2 and 0·70 (95 % CI 0·46, 0·98; P-trend = 0·03) for folate. Other than that for sex (P < 0·05), the P-interactions with age, BMI, smoking status or having a family history of diabetes were >0·10. In conclusion, higher dietary intakes of vitamins C, B2 and folate, but not other water-soluble vitamins, were associated with reduced risk of type 2 diabetes in Japanese women.

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Effects of vitamins C and D in type 2 diabetes mellitus

Cited by 19 publications

References 75 publications

Effects of Vitamin C supplementation on the glycemic control and cardiovascular risk in type II Diabetes Mellitus

Effects of Vitamin C supplementation on the glycemic control and cardiovascular risk in type II Diabetes Mellitus

Vitamin C decreases the obesogenic and hyperglycemic effect of invert sugar in prediabetic rats

Among the water-soluble vitamins, dietary intakes of vitamins C, B₂and folate are associated with the reduced risk of diabetes in Japanese women but not men

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Effects of vitamins C and D in type 2 diabetes mellitus

Cited by 19 publications

References 75 publications

Effects of Vitamin C supplementation on the glycemic control and cardiovascular risk in type II Diabetes Mellitus

Effects of Vitamin C supplementation on the glycemic control and cardiovascular risk in type II Diabetes Mellitus

Vitamin C decreases the obesogenic and hyperglycemic effect of invert sugar in prediabetic rats

Among the water-soluble vitamins, dietary intakes of vitamins C, B2and folate are associated with the reduced risk of diabetes in Japanese women but not men

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Among the water-soluble vitamins, dietary intakes of vitamins C, B₂and folate are associated with the reduced risk of diabetes in Japanese women but not men