Effects of vitamin U (S-methyl methionine sulphonium chloride) on valproic acid induced liver injury in rats

Sökmen, Bahar Bilgin; Tunalı, Sevim; Yanardağ, Refiye

doi:10.1016/j.fct.2012.07.056

Cited by 56 publications

(66 citation statements)

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“…DG treatment significantly reduced the production of MDA induced by VPA. Besides, VPA-treated mice also showed decreased activity of SOD, which was consistent with previous reports (Sokmen et al, 2012). SOD is an antioxidant 4.…”

Section: Discussionsupporting

confidence: 92%

“…VPA and DG suspensions were prepared in normal saline (NS) and were given to the treatment group by intragastric administration (20 mL/kg) for 14 days. The dosages of VPA and DG were based on previous studies (Sokmen et al, 2012). In all treated groups, mice were anesthetized 24 h after the last administration and blood samples were collected for serum biochemical assays.…”

Section: Animals and Treatmentmentioning

confidence: 99%

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Role of Nrf2 activation and NF-κB inhibition in valproic acid induced hepatotoxicity and in diammonium glycyrrhizinate induced protection in mice

Jin

Xiong

Hou

et al. 2014

Food and Chemical Toxicology

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Section: Discussionsupporting

confidence: 92%

Section: Animals and Treatmentmentioning

confidence: 99%

Role of Nrf2 activation and NF-κB inhibition in valproic acid induced hepatotoxicity and in diammonium glycyrrhizinate induced protection in mice

Jin

Xiong

Hou

et al. 2014

Food and Chemical Toxicology

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“…It has been reported as effective for treatment of gastric mucosal damage induced by ethanol in rats (Watanabe et al 2000). Moreover, it has been shown that vit U is a potentially beneficial agent to reduce the liver damage in VPA-induced hepatotoxicity, probably by decreasing oxidative stress (Sokmen et al 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Vit U is one of the sulfhydryl compounds and is predominantly present in plants such as tomatoes, spinach, corn, celery, and garlic (Sokmen et al 2012). Vit U intermediates many biosynthetic pathways including the inhibition of free radical production, gastric motility disorder, vasolateral pressure, and direct cellular damage through sulfonium functional group (Watanabe et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Vitamin U has a protective effect on valproic acid-induced renal damage due to its anti-oxidant, anti-inflammatory, and anti-fibrotic properties

et al. 2015

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The aim of present study was to investigate the effect of vitamin U (vit U, S-methylmethionine) on oxidative stress, inflammation, and fibrosis within the context of valproic acid (VPA)-induced renal damage. In this study, female Sprague Dawley rats were randomly divided into four groups: Group I consisted of intact animals, group II was given vit U (50 mg/kg/day, by gavage), group III was given VPA (500 mg/kg/day, intraperitonally), and group IV was given VPA + vit U. The animals were treated by vit U 1 h prior to treatment with VPA every day for 15 days. The following results were obtained in vit U + VPA-treated rats: (i) the protective effect of vit U on renal damage was shown by a significant decrease in histopathological changes and an increase in Na(+)/K(+)-ATPase activity; (ii) anti-oxidant property of vit U was demonstrated by a decrease in malondialdehyde levels and xanthine oxidase activity and an increase in glutathione levels, catalase and superoxide dismutase activities; (iii) anti-inflammatory property of vit U was demonstrated by a decrease in tumor necrosis factor-α, interleukin-1β, monocyte chemoattractant protein-1 levels, and adenosine deaminase activity; (iv) anti-fibrotic effect of vit U was shown by a decrease in transforming growth factor-β, collagen-1 levels, and arginase activity. Collectively, these data show that VPA is a promoter of inflammation, oxidative stress, and fibrosis which resulted in renal damage. Vit U can be proposed as a potential candidate for preventing renal damage which arose during the therapeutic usage of VPA.

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“…Although it has been called vitamin, it hasn't been accepted into vitamin classification. Besides, this compound has many useful features like hypolipidemic (18), hepatoprotective (19) and gastroprotective effects (20) and wound-healing properties (21).…”

Section: Introductionmentioning

confidence: 99%

Vitamin U ameliorates glycoprotein components, enzyme and tissue factor activities of amiodarone toxicity in liver

Türkyılmaz

Yanardağ

2016

Marmara Pharm J

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In this study, we aimed to investigate the protective effect of Vitamin U (Vit U) on amiodarone (AMD)-induced hepatotoxicity. Male Sprague-Dawley rats were randomly divided into four groups. Group I was control animals receiving corn oil for 7 days, Group II consisted of animals receiving Vit U (50 mg/kg) for 7 days, Group III consisted of animals receiving AMD (100 mg/kg) for 7 days and Group IV consisted of animals given AMD and Vit U (in same dose and time). AMD and Vit U were administered to rats by gavage. On the 8th day, all the animals fasted overnight were sacrificed. Blood and liver tissue samples were taken from animals. Serum total cholesterol levels and liver gamma glutamyl transferase (transpeptidase) adenosine deaminase and tissue factor activities, liver glycoprotein component level such as fucose, hexose and hexosamine were determined. All the parameters were found to be increased in AMD group as compared to control group. Administration of Vit U reversed these effects in AMD group. According to these results, we can conclude that Vit U can prevent AMD-induced liver injury.

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Effects of vitamin U (S-methyl methionine sulphonium chloride) on valproic acid induced liver injury in rats

Cited by 56 publications

References 50 publications

Role of Nrf2 activation and NF-κB inhibition in valproic acid induced hepatotoxicity and in diammonium glycyrrhizinate induced protection in mice

Role of Nrf2 activation and NF-κB inhibition in valproic acid induced hepatotoxicity and in diammonium glycyrrhizinate induced protection in mice

Vitamin U has a protective effect on valproic acid-induced renal damage due to its anti-oxidant, anti-inflammatory, and anti-fibrotic properties

Vitamin U ameliorates glycoprotein components, enzyme and tissue factor activities of amiodarone toxicity in liver

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